Protective effects of the combination Bifidobacterium longum plus lactoferrin against NSAID-induced enteropathy

Fornai, Matteo; Pellegrini, Carolina; Benvenuti, Laura; Tirotta, Erika; Gentile, Daniela; Natale, Gianfranco; Ryskalin, Larisa; Colucci, Rocchina; Piccoli, Elena; Ghelardi, Emilia; Blandizzi, Corrado; Antonioli, Luca

doi:10.1016/j.nut.2019.110583

Cited by 18 publications

(27 citation statements)

References 38 publications

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“…A recent publication examined the protective effects of a combination of the probiotic Bifidobacterium longum BB536 (2.5 × 106 CFU/rat twice daily) with the prebiotic lactoferrin (100 mg/kg twice daily) in a rat model of diclofenac-induced enteropathy [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

Influence of Microbiota on NSAID Enteropathy: A Systematic Review of Current Knowledge and the Role of Probiotics

et al. 2020

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Microbiota are increasingly studied, providing more precise information on their important role in physiologic processes. They also influence some pathologic processes, such as NSAIDinduced enteropathy. This side effect is much more diffuse than it has been described in the past. It derives mainly from the local action of the medicines and is caused by the local binding of gram-negative bacterial lipopolysaccharides and infiltration of neutrophils into the intestinal mucosa. The initial interest in the interaction between these damages and microbiota is very old, but new and interesting data are available. This review aims to focus on recent studies on NSAID-induced enteropathy, an often-underestimated medical condition, and on the influence of microbiota on this condition. Apart from the broadly investigated use of antibiotics and other mucosal protective solutions, this systematic review focuses mostly on the use of probiotics, which directly influence intestinal microflora. Other important factors influencing NSAID-induced enteropathy, such as sex, advanced age, infection and use of proton pump inhibitors, are also discussed.

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Section: Resultsmentioning

confidence: 99%

Influence of Microbiota on NSAID Enteropathy: A Systematic Review of Current Knowledge and the Role of Probiotics

et al. 2020

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“…Furthermore, the administration of Bifidobacterium adolescentis or Faecalibacterium prausnitzii prior naproxen treatment results in a significant reduction of the intestinal damage in rats, probably through an effect on the biosynthesis of cytoprotective short-chain fatty acids (Syer et al, 2015). Recently, it has been reported that the combination of lactoferrin with Bifidobacterium longum protects against diclofenac induced-enteropathy in rats partially by modulating the TLR-2/-4/NF-kB pathways (Fornai et al, 2020). So far, few studies have been performed in humans to investigate whether modulation of the gut microbiota with probiotics is an effective therapeutic approach against NSAID-induced enteropathy, and the results of these studies are discordant (Montalto et al, 2013).…”

Section: Therapeutic Interventions Targeting the Gut Microbiotamentioning

confidence: 99%

Section: Therapeutic Interventions Targeting the Gut Microbiotamentioning

confidence: 99%

NSAID–Gut Microbiota Interactions

Maseda

Ricciotti

2020

Front. Pharmacol.

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Nonsteroidal anti-inflammatory drugs (NSAID)s relieve pain, inflammation, and fever by inhibiting the activity of cyclooxygenase isozymes (COX-1 and COX-2). Despite their clinical efficacy, NSAIDs can cause gastrointestinal (GI) and cardiovascular (CV) complications. Moreover, NSAID use is characterized by a remarkable individual variability in the extent of COX isozyme inhibition, therapeutic efficacy, and incidence of adverse effects. The interaction between the gut microbiota and host has emerged as a key player in modulating host physiology, gut microbiota-related disorders, and metabolism of xenobiotics. Indeed, host-gut microbiota dynamic interactions influence NSAID disposition, therapeutic efficacy, and toxicity. The gut microbiota can directly cause chemical modifications of the NSAID or can indirectly influence its absorption or metabolism by regulating host metabolic enzymes or processes, which may have consequences for drug pharmacokinetic and pharmacodynamic properties. NSAID itself can directly impact the composition and function of the gut microbiota or indirectly alter the physiological properties or functions of the host which may, in turn, precipitate in dysbiosis. Thus, the complex interconnectedness between host-gut microbiota and drug may contribute to the variability in NSAID response and ultimately influence the outcome of NSAID therapy. Herein, we review the interplay between host-gut microbiota and NSAID and its consequences for both drug efficacy and toxicity, mainly in the GI tract. In addition, we highlight progress towards microbiota-based intervention to reduce NSAIDinduced enteropathy.

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“…Lactobacillus fermentum cell-free supernatant (LCFS) caused cancer cell death in 3D HCT-116 conditions through the induction of apoptosis in the colon cancer cell line and the antiproliferative activity by the inhibition of NF-κB signaling [129]. The use of lactoferrin and Bifidobacterium longum BB536 managed the enteropathy caused by diclofenac in rat samples by modulating the proinflammatory pathway of TLR-2/-4/NF-kB [130]. Othman et al [131], studied the effect of inactivated Bifidobacterium longum intake on obese diabetes affected mice.…”

Section: Health Promoting Effect Of Prebiotics Probiotics and Synbimentioning

confidence: 99%

An Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics

Durazzo

Nazhand

Lucarini

et al. 2020

IJMS

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Over the last few years, the application of nanotechnology to nutraceuticals has been rapidly growing due to its ability to enhance the bioavailability of the loaded active ingredients, resulting in improved therapeutic/nutraceutical outcomes. The focus of this work is nanoprebiotics and nanoprobiotics, terms which stand for the loading of a set of compounds (e.g., prebiotics, probiotics, and synbiotics) in nanoparticles that work as absorption enhancers in the gastrointestinal tract. In this manuscript, the main features of prebiotics and probiotics are highlighted, together with the discussion of emerging applications of nanotechnologies in their formulation. Current research strategies are also discussed, in particular the promising use of nanofibers for the delivery of probiotics. Synbiotic-based nanoparticles represent an innovative trend within this area of interest. As only few experimental studies on nanoprebiotics and nanoprobiotics are available in the scientific literature, research on this prominent field is needed, covering effectiveness, bioavailability, and safety aspects.

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Protective effects of the combination Bifidobacterium longum plus lactoferrin against NSAID-induced enteropathy

Cited by 18 publications

References 38 publications

Influence of Microbiota on NSAID Enteropathy: A Systematic Review of Current Knowledge and the Role of Probiotics

Influence of Microbiota on NSAID Enteropathy: A Systematic Review of Current Knowledge and the Role of Probiotics

NSAID–Gut Microbiota Interactions

An Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics

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