NSAID–Gut Microbiota Interactions

Maseda, Damián; Ricciotti, Emanuela

doi:10.3389/fphar.2020.01153

Cited by 76 publications

(65 citation statements)

References 215 publications

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“…These therapies have often a high toll to pay, including GM disruption, with all the associated consequences. 76,77 At the same time, GM modulates the efficacy of therapies. Flavonoids, in this context, may offer an interesting option, as they are able to modulate the GM in a positive way, reducing inflammation and the presence of dangerous species.…”

Section: Flavonoids Microbiota and Diseasementioning

confidence: 99%

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Luteolin, inflammation and cancer: Special emphasis on gut microbiota

et al. 2021

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Luteolin belongs to the family of flavonoids, which have anti-inflammatory functions, potentially useful in a clinical context, particularly for patients suffering from cancer, neuropsychiatric disorders, inflammatory bowel conditions. This peculiarity has been used for centuries in traditional Chinese medicine, for many different diseases. Its anti-inflammatory effects might be particularly relevant in cancer, with some studies reporting anti-angiogenesis, anti-metastatic, and apoptotic effects on cancer cells by luteolin and other flavonoids. In this article, we analyze the anti-inflammatory role of luteolin, discussing the pathways it may act on. We will then discuss the possible role of microbiota in inflammatory modulation by luteolin. Finally, the possible therapeutic applications of luteolin's anti-inflammatory properties will be analyzed, with a particular focus on cancer.

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Section: Flavonoids Microbiota and Diseasementioning

confidence: 99%

“…Therapy usually consists of combinations of different anti‐inflammatory drugs and immune modulators. These therapies have often a high toll to pay, including GM disruption, with all the associated consequences 76,77 . At the same time, GM modulates the efficacy of therapies.…”

Section: Introductionmentioning

confidence: 99%

Luteolin, inflammation and cancer: Special emphasis on gut microbiota

et al. 2021

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“…Opioids, such as morphine, may be prescribed to limit postoperative pain in orthopedic patients; however, there are a multitude of side effects associated with their use including but not limited to nausea, vomiting, dizziness, and cardiorespiratory dysfunction 16 . Nonsteroidal anti‐inflammatory drugs (NSAIDs), may also be used to combat musculoskeletal pain although they too have side effects, such as reflux and stomach ulcers 17 . NSAIDs are used withcaution (or not recommended at all) in the immediate postoperative period on orthopaedic patients, due to the possible risk of bleeding 18 .…”

Section: Introductionmentioning

confidence: 99%

“…16 Nonsteroidal anti-inflammatory drugs (NSAIDs), may also be used to combat musculoskeletal pain although they too have side effects, such as reflux and stomach ulcers. 17 NSAIDs are used withcaution (or not recommended at all) in the immediate postoperative period on orthopaedic patients, due to the possible risk of bleeding. 18 Acetaminophen is preferred over NSAIDs or opioids due to its good safety profile, but high doses should be avoided in patients with underlying liver disorders.…”

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confidence: 99%

Vitamin C in orthopedic practices: Current concepts, novel ideas, and future perspectives

Oakes

Bolia

Weber

et al. 2021

Journal Orthopaedic Research

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Vitamin C (ascorbic acid), is an important antioxidant that has been applied broadly in the field of orthopaedics. Current research on vitamin C examines the molecule's role in bone and tendon physiology, as well as joint replacement and Postoperative pain. Most laboratory and human studies associate the use of vitamin C with improved bone health and tendon healing. Recent literature moderately supports the use of vitamin C to improve functional outcomes, decreased postoperative pain, and prevent complex regional pain syndrome following orthopaedic procedures. The perioperative use of vitamin C in patients undergoing joint replacement surgery and anterior cruciate ligament reconstruction is still under investigation. Overall, there is need for high-quality human trials to confirm whether vitamin C can potentiate the outcomes of orthopaedic procedures and to determine optimal dosage and means of administration to maximize its proposed benefits. The purpose of this review was to summarize the application of vitamin C in orthopaedic practices and to identify potential areas for future study. K E Y W O R D S bone, orthopedics, pain management, tendons, vitamin C 1 | INTRODUCTION Vitamin C (ascorbic acid), is an important antioxidant and deficiency of this mineral is most often associated with scurvy. 1 Vitamin C is vital to the production of collagen in both bone and connective tissue and it has been associated with improved collagen synthesis and subsequent tendon healing. 2-4 It also neutralizes free radicals, which helps to decrease oxidative stress and inflammation. 5 Vitamin C has also been used as a supplement in orthopaedic patients. 6-8 Vitamin C has been linked to improved bone mineral density as well as decreased risk of bone fracture and osteoporosis. 9-11 Furthermore, there is recent evidence to suggest that vitamin C may have a protective role in osteoarthritis. 12 From a postoperative recovery perspective, vitamin C has been found to reduce the incidence of complex regional pain syndrome (CRPS) and improve functional outcomes. 5,13 However, some of these conclusions on the therapeutic effect of vitamin C continue to be debated. 14 The purpose of this review was to summarize the role of vitamin C in orthopaedic practices and to identify potential areas for future study. 1.1 | Perioperative pain management Postoperative pain exists as a common challenge to orthopaedic surgeons, as it is linked to increased risk of postoperative complications, longer hospital stays, and significant delays in the return to regular function. 15 Opioids, such as morphine, may be prescribed to limit postoperative pain in orthopedic patients; however, there are a multitude of side effects associated with their use

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“…A recently published review by Maseda and Ricciotti (2020), "NSAID-gut microbiota interaction" is therefore potentially of major interests because the microbiota plays such an important pathophysiological role in the small bowel damage due to these drugs. Furthermore, NSAIDs may independently alter the microbiome and collectively these changes may lead to alterations in the pharmacokinetic profiles of NSAIDs, alter their efficacy, etc.…”

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confidence: 99%