Protective effects of quercetin-3-rhamnoglucoside (rutin) on ischemia-reperfusion injury in rat small intestine

Itagaki, Shirou; Oikawa, Setsu; Ogura, Jiro; Kobayashi, Masaki; Hirano, Takeshi; Iseki, Ken

doi:10.1016/j.foodchem.2009.04.103

Cited by 33 publications

(21 citation statements)

References 23 publications

(29 reference statements)

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“…We have evaluated that the inhibitory effect of polyphenols such as rutin, chlorogenic acid, caffeic acid and ferulic acid that have antioxidant activities on xanthine oxidase-induced light emission, fenton-reaction-induced chemiluminescence and BODIPY oxidation. 23,36,37) In these reports, we reported that the IC 50 values of rutin, chlorogenic acid, caffeic acid and ferulic acid on xanthine-oxidase induced light emission by MPEC assay were about 71.7, 41.0, 10.1 and 6614 mM, respectively. 23,36,37) It is suggested that the effect of genistein on the inhibition of xanthine oxidase would not be so strong compared with other polyphenols from the point that the IC 50 value of genistein in this study was about 700 mM (Fig.…”

Section: Discussionmentioning

confidence: 92%

“…We have already reported that other antioxidants exhibit antioxidant ac-tivities and attenuate intestinal I/R injury. 23,36,41) Reperfusion of the ischemic intestine results in an increase in vascular permeability to Evans blue dye (Fig. 4).…”

Section: Discussionmentioning

confidence: 99%

“…For the prevention of these diseases, an approach focusing on the health aspects of natural antioxidants should be beneficial. 23,36,37,41) In order to develop new functional foods, it is important to select a suitable ingredient that has a scientific background. The results of this study should provide a scientific background of the usefulness of genistein as a functional food ingredient.…”

Section: Discussionmentioning

confidence: 99%

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Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine

Sato

Itagaki

Oikawa

et al. 2011

Biological & Pharmaceutical Bulletin

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Ischemia-reperfusion (I/R) injury of the intestine is an important factor associated with high rates of morbidity and mortality. Intestinal I/R is a common clinical problem in the settings of severe burns, circulatory shock and strangulation ileus. Intestinal I/R damages remote organs and promotes multi-organ failure. It has been shown that enteral feeding before ischemic insults is beneficial for reducing organ injury and improving survival after intestinal I/R. In that study, the authors used a standard complex enteral diet and they suggested that it is important to find new nutrient formulas. Since reactive oxygen species are responsible for intestinal I/R injury, we focused on a dietary polyphenol, the soy isoflavone genistein. Genistein has a wide spectrum of biochemical and pharmacological activities. However, the possibility of a protective effect of genistein as enteral nutrition on I/R injury has not been investigated. We therefore investigated the protective effect of genistein on oxidative injury using intestinal I/R model rats. We found that genistein, which has combined antioxidant activity from radical scavenging, xanthine oxidase inhibition and chain-breaking effects, exhibits a protective effect on intestinal I/R injury. The results suggest that genistein, a soy isoflavone, has the possibility as a new nutrient formula of enteral feeding.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine

Sato

Itagaki

Oikawa

et al. 2011

Biological & Pharmaceutical Bulletin

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“…Among the therapeutic modalities able to mitigate the harmful effects of local and remote I/R, there are the use of: antioxidants and anti-inflammatory medications (Kostopanagiotou et al 2007, Avgerinos et al 2010, Yurdakan et al 2012, use of propofol (Vasileiou et al 2012), green tea (Abdeen et al 2011), hydrocortisone (Alves et al 2011), rutin (Itagaki et al 2010), glutamine (Pagliosa et al 2009), methylene blue (Greca et al 2008), dimethyl sulfoxide (DMSO) (Dabareiner et al 2005), copaiba oils (Paiva et al 2004), among others.…”

Section: Introductionmentioning

confidence: 99%

Allogenic mesenchymal stem cell intravenous infusion in reparation of mild intestinal ischemia/reperfusion injury in New Zealand rabbits

et al. 2018

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The present study aimed to evaluate the efficacy of mesenchymal stem cell (MSC) infusion, derived from adipose tissue, on reduction of local and remote tissue damage caused by the event of experimental intestinal I/R in New Zealand breed rabbits. For obtaining, characterization, and cultivation of MSC derived from adipose tissue (MSC-Adp), 3 juvenile animals (four months old) were used. The cells were considered to be viable for therapy after the fourth passage (in vitro phase). For the in vivo stage, 24 young adult animals (six months old) were used, weighing approximately 3.5 kg, in which were randomly divided into two groups, called: IR treated with MSC (I2H/R5H MSC 3D; I2H/R5H MSC 7D); IR treated with PBS (I2H/R5H PBS 3D; I2H/R5H PBS 7D). The animals were anesthetized and submitted to pre-retro-umbilical midline celiotomy. The extramural peri-intestinal marginal artery was located and clamped (predetermined and standardized region) with the aid of a vascular clip, promoting a 2 hour blood flow interruption. After this period, blood flow was reestablished, inhalatory anesthesia was suspended, and the animals awaken. After 5 hours of reperfusion, the treatments were performed by intravenous infusion according to the experimental groups. The animals were evaluated 72 hours and seven days after the treatment as for the macroscopic appearance (color and peristaltism) of the jejunal segment, and by histological evaluation of the ischemic segment for the presence or absence of destruction of the intestinal mucosa, edema, bleeding, dilation of lymph vessels, and presence of polymorphonuclear inflammatory cells, both in the mucosa and submucosa. The observed results revealed that the groups treated with MSC-Adp obtained smaller mucosal and submucosal lesions when compared to the groups treated with PBS. Also, MSC-Adp treated groups obtained controlled inflammatory response and higher mitotic rate, outcomes related to the therapeutic potential of MSC. Infusion of stem cells attenuated the lesions caused by intestinal I/R in both MSC groups when compared to the group treated with PBS.

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“…Qu became the topic of increasing interest based on its various bioactivities such as inoxidability, antiviral and antitumor properties, and adjusting the immune function [7][8][9]. One of simple methods for extraction or separation of active components from herbs was MIT.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Quercetin Molecularly Imprinted Polymers

Chen

Wang

et al. 2012

Designed Monomers and Polymers

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Molecularly imprinted polymers (MIPs) of Quercetin (Qu) were prepared using acrylamide (AM), acrylic acid (AA) and methyl methacrylate (MMA) as functional monomers, N,N -methylenebiacrylamide (NMBA) as cross-linker and the redox system L-ascorbic acid (Vc) and hydrogen peroxide (H 2 O 2 ) as initiator in mixed methanol/ethanol media. During the optimization process, another compound, Isorhamnetin (IRa), which possesses a very similar structure with Qu, was recruited as the chaff interference, and the separation degree of MIPs to Qu and IRa was adopted to investigate and optimize the influence of each factor. The product prepared at under optimal conditions showed a separation degree of 4.00 of Qu from the mixture of Qu and IRa with the same mass concentration.

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Protective effects of quercetin-3-rhamnoglucoside (rutin) on ischemia-reperfusion injury in rat small intestine

Cited by 33 publications

References 23 publications

Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine

Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine

Allogenic mesenchymal stem cell intravenous infusion in reparation of mild intestinal ischemia/reperfusion injury in New Zealand rabbits

Preparation of Quercetin Molecularly Imprinted Polymers

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