Protective effects of polyphenol-rich infusions from carob (Ceratonia siliqua) leaves and cladodes of Opuntia ficus-indica against inflammation associated with diet-induced obesity and DSS-induced colitis in Swiss mice

Aboura, Ikram; Nani, Abdelhafid; Belarbi, Meriem; Murtaza, Babar; Fluckiger, Aurélie; Dumont, Adélie; Benammar, Chahid; Tounsi, Moufida Saïdani; Ghiringhelli, François; Rialland, Mickaël; Hichami, Aziz

doi:10.1016/j.biopha.2017.11.125

Cited by 39 publications

(28 citation statements)

References 81 publications

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“…In contrast, Aboura et al [61] reported that TPC of C. siliqua leaf infusion was 8.93 mg GAE/100 mL infusion. Based on these findings, CsAE exhibits a TPC comparable with those reported by other authors that assume its antioxidant and memory-facilitating activities.…”

Section: Total Phenolic Contentmentioning

confidence: 88%

The Aqueous Extract from Ceratonia siliqua Leaves Protects against 6-Hydroxydopamine in Zebrafish: Understanding the Underlying Mechanism

et al. 2020

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Ceratonia siliqua L. is a Mediterranean medicinal plant traditionally cultivated for its ethnopharmacological benefits, such as antidiarrheal, antidiabetic, enhance acetylcholine, antioxidant, antiatherosclerotic, and for its possible anti-neurodegenerative potential. The aim of the present study was to evaluate the chemical composition, as well as the cognitive-enhancing, anxiolytic, and antioxidant activities of the aqueous extract from C. siliqua (CsAE) leaves against 6-hydroxydopamine (6-OHDA) zebrafish Parkinson’s disease (PD) model. CsAE (0.1, 0.3, and 1 mg/L) was administered by immersion to zebrafish (Danio rerio) for eight consecutive days and one hour before each behavioral test of each day, while 6-OHDA (250 µM) treatment was supplied one day before the novel tank diving test (NTT). Qualitative and quantitative analyses were performed by the ultra-high-performance liquid chromatography (UHPLC) analysis. The memory performance was evaluated through the NTT and Y-maze tests. Additionally, the in vitro and in vivo antioxidant status and acetylcholinesterase (AChE) activity was also assessed. Our finds demonstrated that CsAE presented positive antioxidant and anti-AChE activities, which contributed to the improvement of cognitive function in the 6-OHDA zebrafish PD model.

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Section: Total Phenolic Contentmentioning

confidence: 88%

The Aqueous Extract from Ceratonia siliqua Leaves Protects against 6-Hydroxydopamine in Zebrafish: Understanding the Underlying Mechanism

et al. 2020

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“…In our study, rats fed a HFAD had increased protein expression of inflammatory cytokines including IL‐6 and TNF‐α than controls. It has been previously reported that obesity is a low‐grade inflammation characterized by an increased production of various pro‐inflammatory cytokines (Aboura et al, ). Interestingly, the plasma level of both IL‐6 and TNF‐α was significantly reduced in rats fed HFAD supplemented with the Zl pulp (HFADP) than rats receiving HFAD only.…”

Section: Discussionmentioning

confidence: 99%

Antiinflammatory and antioxidant activities of a polyphenol‐rich extract fromZizyphus lotusL fruit pulp play a protective role against obesity

et al. 2018

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Zizyphus lotus (Zl) is used widely as a source of food and for the treatment of various ailments. Therefore, we investigated the biological activities of Zl against obesity and related disorders. Hence, male Wistar rats received either control diet, high fat diet (HFAD), or HFAD supplemented with the Zl pulp (HFADP) for 14 weeks. RAW 264.7 cells were used for the determination of antiinflammatory activities in vitro. It was observed that HFDP resulted in significantly reduced weight, blood sugar, and oxidative stress than HFAD. In addition, Zl extract co‐treatment with LPS reduced the mRNA expression of MCP‐1, pro‐inflammatory cytokines (IL‐6, TNF‐α), and increased the level of IL‐10, an antiinflammatory cytokine, in LPS‐stimulated RAW 264.7 cells. Moreover, nitric oxide synthesis and the expression of iNOS were decreased by Zl extract in RAW 264.7 cells. Zl extract also possessed a significant antioxidant capacity and ferric‐reducing power. Our results validate the traditional use of Zl. Practical applications Zizyphus lotus is commonly used as food in different countries and is easily available. Scientific validation of the traditional use of plants can be significant in the prevention and treatment of different disorders. Naturally occurring products are generally safe to use, have fewer side effects, and can be self‐administered. Hence, specialized health‐care supervision is not necessary. Our study supports the traditional use of Zizyphus lotus to prevent and decrease obesity and related disorders.

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“…However, Bousenna et al (17) evaluated a polyphenol-rich grape pomace extract on rats challenged with DSS and observed attenuation in the clinical signs, colon shortening, and limitation of histological lesions usually observed in DSS-induced colon inflammation. Another study carried out by Aboura et al (37) reported that polyphenol-rich infusion from carob leaves and Opuntia cladodes presented anti-inflammatory effects, counteracted intestinal permeability and colon histological lesions, and decreased DSS-induced proinflammatory cytokine expression in mice. Samsami-Kor et al (38) also showed that resveratrol, a highly studied polyphenol that is abundant in natural sources like grapes, could decrease clinical disease activity index and quality of life in patients with ulcerative colitis (UC) in a randomized, double-blind clinical trial.…”

Section: Discussionmentioning

confidence: 97%

Effects of Dietary Grape Seed Meal Bioactive Compounds on the Colonic Microbiota of Weaned Piglets With Dextran Sodium Sulfate-Induced Colitis Used as an Inflammatory Model

et al. 2020

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Microbiota affects host health and plays an important role in dysbiosis. The study examined the effect of diet including grape seed meal (GSM) with its mixture of bioactive compounds on the large intestine microbiota and short-chain fatty acid synthesis in weaned piglets treated with dextran sodium sulfate (DSS) as a model for inflammatory bowel diseases. Twenty-two piglets were included in four experimental groups based on their diet: control, DSS (1 g/kg/b.w.+control diet), GSM (8% grape seed meal inclusion in control diet), and DSS+GSM (1 g/kg/b.w., 8% grape seed meal in control diet). After 30 days, the colon content was isolated and used for microbiota sequencing on an Illumina MiSeq platform. QIIME 1.9.1 pipeline was used to process the raw sequences. Both GSM and DSS alone and in combination affected the diversity indices and Firmicutes:Bacteroidetes ratio, with significantly higher values in the DSS-afflicted piglets for Proteobacteria phylum, Roseburia, Megasphera and CF231 genus, and lower values for Lactobacillus. GSM with high-fiber, polyphenol and polyunsaturated fatty acid (PUFA) content increased the production of butyrate and isobutyrate, stimulated the growth of beneficial genera like Prevotella and Megasphaera, while countering the relative abundance of Roseburia, reducing it to half of the DSS value and contributing to the management of the DSS effects.

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Protective effects of polyphenol-rich infusions from carob (Ceratonia siliqua) leaves and cladodes of Opuntia ficus-indica against inflammation associated with diet-induced obesity and DSS-induced colitis in Swiss mice

Cited by 39 publications

References 81 publications

The Aqueous Extract from Ceratonia siliqua Leaves Protects against 6-Hydroxydopamine in Zebrafish: Understanding the Underlying Mechanism

The Aqueous Extract from Ceratonia siliqua Leaves Protects against 6-Hydroxydopamine in Zebrafish: Understanding the Underlying Mechanism

Antiinflammatory and antioxidant activities of a polyphenol‐rich extract fromZizyphus lotusL fruit pulp play a protective role against obesity

Effects of Dietary Grape Seed Meal Bioactive Compounds on the Colonic Microbiota of Weaned Piglets With Dextran Sodium Sulfate-Induced Colitis Used as an Inflammatory Model

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