Antiinflammatory and antioxidant activities of a polyphenol‐rich extract fromZizyphus lotusL fruit pulp play a protective role against obesity

Abstract

Zizyphus lotus (Zl) is used widely as a source of food and for the treatment of various ailments. Therefore, we investigated the biological activities of Zl against obesity and related disorders. Hence, male Wistar rats received either control diet, high fat diet (HFAD), or HFAD supplemented with the Zl pulp (HFADP) for 14 weeks. RAW 264.7 cells were used for the determination of antiinflammatory activities in vitro. It was observed that HFDP resulted in significantly reduced weight, blood sugar, and oxidative stress than HFAD. In addition, Zl extract co‐treatment with LPS reduced the mRNA expression of MCP‐1, pro‐inflammatory cytokines (IL‐6, TNF‐α), and increased the level of IL‐10, an antiinflammatory cytokine, in LPS‐stimulated RAW 264.7 cells. Moreover, nitric oxide synthesis and the expression of iNOS were decreased by Zl extract in RAW 264.7 cells. Zl extract also possessed a significant antioxidant capacity and ferric‐reducing power. Our results validate the traditional use of Zl. Practical applications Zizyphus lotus is commonly used as food in different countries and is easily available. Scientific validation of the traditional use of plants can be significant in the prevention and treatment of different disorders. Naturally occurring products are generally safe to use, have fewer side effects, and can be self‐administered. Hence, specialized health‐care supervision is not necessary. Our study supports the traditional use of Zizyphus lotus to prevent and decrease obesity and related disorders.

Differential effects of oilseed protein hydrolysates in attenuating inflammation in murine macrophages

“…2c). In addition, our data demonstrated that LPS-induced inflammation led to a significant increase in anti-inflammatory IL-10 gene expression, which is consistent with other studies (Salkowski et al, 1997;Sun, H. et al, 2017;Ghalem et al, 2018), and emphasizes the importance of IL10 immuno-regulatory function.…”

Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities

“…Among these substances, polyphenols from jujube, secondary metabolites of plants, are important determinants of the nutritional and organoleptic qualities of Zizyphus lotus [21,22]. Several bioactive compounds extracted from jujubes have attracted the attention of many researchers due to their important biological actions, including antioxidant [19,23], enzyme inhibitory [24,25], antiproliferative and cytotoxic effects [24,26], anti-inflammatory, and other effects [27][28][29], which can be used in the food, pharmaceutical, and cosmetic industry.…”

Antimicrobial and antioxidant activity of pulp extracts from three populations ofZiziphus lotusL.

“…Many authors showed that Z. lotus has a significant antioxidant potential (Ghalem et al , 2018; Ghazghazi et al , 2014; Bakhtaoui et al , 2014; Bakchiche et al , 2013; Li et al , 2005). Rajinder et al (2015), tested the antiradical activity of the aqueous extract of the fruit of Ziziphus mauritiana and Eriobotrya japonica ,showed that the inhibition percentage for these two species were respectively 74.89 per cent and 51.07 per cent at a concentation of 200 mg/ml.…”