Protective effects of plant‐derived natural products on renal complications

Yaribeygi, Habib; Simental‐Mendía, Luis E.; Butler, Alexandra E.; Sahebkar, Amirhossein

doi:10.1002/jcp.27950

Cited by 32 publications

(13 citation statements)

References 170 publications

(235 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, it was found cinnamaldehyde treatment improves kidney function as cinnamaldehyde inhibited nephropathy caused by (AGE) products through suppression of the NO pathway activated by the JAK2-STAT1/STAT3 pathway [22]. Furthermore, it significantly improves oxidative stress in renal tissues by suppression of free radical generation and potentiation of ADS elements [60]. Also, oral administration of cinnamaldehyde decreases serum uric acid levels and that can be explained by its ability to inhibit the activity of xanthine oxidase enzyme [33].…”

Section: Discussionmentioning

confidence: 99%

Potential role of cinnamaldehyde and costunolide to counteract metabolic syndrome induced by excessive fructose consumption

Rashwan

El-Beltagy

Saleh

et al. 2019

Beni-Suef Univ J Basic Appl Sci

View full text Add to dashboard Cite

Background: One of the serious public health problems in the world is metabolic syndrome. It includes visceral obesity, dyslipidemia, insulin resistance, hyperglycemia, and hypertension. As a contributor to almost all the classic signs of metabolic syndrome, fructose was the ideal choice. There are certain shortcomings with existing drugs for insulin-resistant treatment. Plants still represent the main source of most available medicines. Cinnamaldehyde (CNA) is an active principle of Cinnamomum zeylanicum. Costunolide (CE) is natural sesquiterpene lactones, which is the main bioactive constituent of Saussurea lappa. The main aim of the present study is to investigate the effect of the synthetic antidiabetic agent (metformin) in comparison with natural constituents (cinnamaldehyde, costunolide) after developing a reliable model for insulin resistance by using high fructose diet (HFD). Results: It was found that HFD increased plasma glucose, insulin, glycosylated hemoglobin, HbA1c, serum total cholesterol, LDL-cholesterol, triglyceride, ALT, AST, creatinine, and uric acid. Moreover, HFD decreased hepatic reduced glutathione and superoxide dismutase levels. While oral administration of cinnamaldehyde and costunolide significantly decreased plasma glucose, HbA1c, total cholesterol, LDL-cholesterol, triglyceride, and increased level of hepatic reduced glutathione and superoxide dismutase activity. Also, cinnamaldehyde and costunolide restored the altered plasma levels of ALT, AST, creatinine, and uric acid to normal. Conclusions: The results of this experimental study showed that cinnamaldehyde and costunolide could be used as safe drugs for treating different abnormalities of metabolic syndrome.

show abstract

Section: Discussionmentioning

confidence: 99%

Potential role of cinnamaldehyde and costunolide to counteract metabolic syndrome induced by excessive fructose consumption

Rashwan

El-Beltagy

Saleh

et al. 2019

Beni-Suef Univ J Basic Appl Sci

View full text Add to dashboard Cite

show abstract

“…Increased serum levels of creatinine, uric acid, and urea in triton‐toxified rats revealed renal damage (El‐Demerdash & Nasr, 2014; Josiah et al, 2019; Vinod et al, 2018). Like MHT, several plant and plant‐derived foods have been reported to afford protection against kidney damage (El‐Demerdash & Nasr, 2014; Yaribeygi, Simental‐Mendía, Butler, & Sahebkar, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Increase in HDL-C level and the reduction in levels of LDL-C, VLDL-C, TC, and TG in hyperlidemic rats post-treated with MHT is indicative of selective clearance of circulating atherogenic lipids. Nasr, 2014;Josiah et al, 2019;Vinod et al, 2018 Yaribeygi, Simental-Mendía, Butler, & Sahebkar, 2019).…”

Section: Discussionmentioning

confidence: 99%

Toxicological and pharmacological assessment of a multiherbal phytopharmaceutical on Triton X‐1339‐induced hyperlipidemia and allied biochemical dysfunctions

et al. 2020

View full text Add to dashboard Cite

This study investigated the safety and therapeutic effect of a multiherbal tea (MHT) on Triton X-1339-induced hyperlipidemia and associated biochemical and tissue dysfunctions. An infusion of the MHT was assessed for phytoconstituents, proximate and mineral composition, and antioxidant activity. Wistar rats administered 200 mg/ kg Triton X-1399 were post-treated with MHT for 14 days followed by biochemical estimations in serum, heart, liver, and kidney of animals. Hematological and histopathological evaluations of the blood, and liver, respectively, were also performed. Different phytochemicals were detected in MHT, toxic metals were absent and antioxidant activity was appreciable. Disturbances in glucose level and redox homeostasis, alterations in liver, kidney, and heart function markers, and imbalances in hematological parameters precipitated by triton toxicity were mitigated by posttreatment with MHT. Multiherbal tea also ameliorated triton-induced hepatic histoarchitectural abnormalities. These results suggest that MHT is apparently an effective antilipemic tea with minimal or no side effects. Practical applications Hyperlipidemia is one of the core risk factors for arteriosclerosis and a major contributor to other adverse health conditions. The prevalence of hyperlipidemia has increased drastically in the last few decades. Plant and plant products have been extensively used in the management of dyslipidemia and many plant-based antilipemic products with poorly defined toxicity and pharmacological profiles abound in the market. The results of this study demonstrated the protective effects of a MHT against triton-induced hyperlipidemia, atherogenic tendency, and dysfunction of key organs in rats and lent credence to its therapeutic relevance in the management of hyperlipidemia and related diseases. K E Y W O R D S antilipemic, hyperlipidemia, multiherbal tea, multi-organ protection, oxidative stress 1999) radicals scavenging activities as well as cupric ion (Cu 2+) reducing capacity (Apak, Güçlü, Ozyürek, & Karademir, 2004). 2.4 | Determination of proximate and mineral composition of MHT The proximate and mineral compositions of MHT were determined following previously established protocols (Horwitz & Latimer, 2005). 2.5 | In vivo evaluation of MHT in Triton-induced hyperlipidemia 2.5.1 | Animal grouping and treatment Male Wistar rats weighing 180 ± 20 g were obtained from the

show abstract

“…Kidney is one of the important organs for secretion, reabsorption of aminoacids and glucose, production of active form of vitamin D, and also plays a significant role in immunologic and metabolic functions [16][17][18][19][20]. Troxerutin has shown high efficacy in protection of kidney (Fig.…”

Section: Renoprotective Effectmentioning

confidence: 99%

Biological and Therapeutic Effects of Troxerutin: Molecular Signaling Pathways Come into View

et al. 2021

View full text Add to dashboard Cite

Flavonoids consist a wide range of naturally occurring compounds which are exclusively found in different fruits and vegetables. These medicinal herbs have a number of favourable biological and therapeutic activities such as antioxidant, neuroprotective, renoprotective, anti-inflammatory, anti-diabetic and anti-tumor. Troxerutin, also known as vitamin P4, is a naturally occurring flavonoid which is isolated from tea, coffee and cereal grains as well as vegetables. It has a variety of valuable pharmacological and therapeutic activities including antioxidant, anti-inflammatory, anti-diabetic and anti-tumor. These pharmacological impacts have been demonstrated in in vitro and in vivo studies. Also, clinical trials have revealed the efficacy of troxerutin for management of phlebocholosis and hemorrhoidal diseases. In the present review, we focus on the therapeutic effects and biological activities of troxerutin as well as its molecular signaling pathways.

show abstract

Protective effects of plant‐derived natural products on renal complications

Cited by 32 publications

References 170 publications

Potential role of cinnamaldehyde and costunolide to counteract metabolic syndrome induced by excessive fructose consumption

Potential role of cinnamaldehyde and costunolide to counteract metabolic syndrome induced by excessive fructose consumption

Toxicological and pharmacological assessment of a multiherbal phytopharmaceutical on Triton X‐1339‐induced hyperlipidemia and allied biochemical dysfunctions

Biological and Therapeutic Effects of Troxerutin: Molecular Signaling Pathways Come into View

Contact Info

Product

Resources

About