Protective effects of methyl palmitate against silica-induced pulmonary fibrosis in rats

Sharawy, Maha H.; El‐Agamy, Dina S.; Shalaby, Asem; Ammar, El Sayed M

doi:10.1016/j.intimp.2013.04.007

Cited by 30 publications

(27 citation statements)

References 42 publications

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“…Methyl palmitate has been reported to protect against sepsis induced by cecal ligation and needling perforation (Meng et al 1992). Furthermore, methyl palmitate combated inflammation in several models of inflammatory disorders such as: rat paw edema, lipopolysaccharide-induced endotoxemia in rats, lipopolysaccharide-induced acute lung injury in rats and croton oil-induced ear edema in rats (Saeed et al 2012;Sharawy et al 2013).…”

Section: Reactive Oxygen Species (Ros) and Nitrogen Oxygen Speciesmentioning

confidence: 99%

Cytoprotective potential of tiron and methyl palmitate against acetaminophen-induced acute liver injury

Shoeib

Said

Ammar

2016

Can. J. Physiol. Pharmacol.

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Acute liver injury is a debilitating disorder associated with loss of synthetic and detoxifying functions of the liver. This investigation was designed to assess cytoprotective efficacy of daily oral tiron (300 mg/kg) and daily oral methyl palmitate (300 mg/kg) against acetaminophen-induced acute liver injury. Rats were orally pretreated with either tiron or methyl palmitate at doses (300 mg/kg) for 7 days prior to oral acetaminophen (3 g/kg). Biochemical assay of markers of hepatotoxicity indices and oxidative stress was undertaken. Expression of inflammatory cytokine IL-6 was also evaluated. Histopathological examination of liver specimens was carried out as well. Both methyl palmitate and tiron significantly reversed the acetaminophen-induced elevation of biochemical markers (ALT, AST, and ALP) with restoration of SOD levels. Serum albumin levels and GSH liver contents increased, but in a nonsignificant manner. Moreover, methyl palmitate and tiron significantly decreased the level of serum LDH and serum IL-6 levels. Histopathology revealed that tiron markedly reduced the extent of acetaminophen-induced necrosis and methyl palmitate moderately decreased the necrosis in liver tissue. Methyl palmitate (300 mg/kg) and tiron (300 mg/kg) demonstrated promising hepatoprotective effects against acetaminophen-induced acute liver injury via modulation of inflammatory response and alleviation of the oxidative stress, allowing the preservation of hepatic functions.

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Section: Reactive Oxygen Species (Ros) and Nitrogen Oxygen Speciesmentioning

confidence: 99%

Cytoprotective potential of tiron and methyl palmitate against acetaminophen-induced acute liver injury

Shoeib

Said

Ammar

2016

Can. J. Physiol. Pharmacol.

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“…Also, ethyl 9-hexadecenoate has been reported as additive for alcoholic beverages, specifically in the whiskey industry (Nykänen and Suomalainen, 1983) and methyl palmitate has been demonstrated antiinflammatory and antifibrotic effects in experimental animal models of liver injury (Cai et al 2005;RodriguezRivera et al 2008). Furthermore, methyl palmitate has been combated inflammation in several models of inflammatory disorders such as: paw edema, lipopolysaccharide-induced endotoxemia, lipopolysaccharide-induced acute lung injury and croton oil-induced ear edema in rats (Saeed et al 2012;Sharawy et al 2013). Moreover, is one of the best known ligands for pheromone receptors Or47b and Or88a (Dweck et al 2015).…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition of Essential Oils of Passiflora Edulis F. Flavicarpa Agroindustrial Waste

et al. 2017

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The study of the chemical composition of essential oils of shells and seeds of Passiflora edulis f. flavicarpa is discussed. The essential oils were obtained by microwave assisted hydrodistillation (MWHD) as extraction method using Clevenger apparatus. The compounds were separated and identified by gas chromatography mass spectrometry (GC-MS). There were no significant differences of essential oil yields between samples. 20 compounds were detected altogether. Ionol was the main compound in shells (13.15%) and seeds (12.10%). Nevertheless, some fatty acid methyl ester, aldehydes, hydrocarbons and other terpenes were found in minor quantities. These results have not been informed previously and allow adding value to this agroindustrial waste.

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“…These changes were graded in terms of severity and distribution and scored by a grading system as described previously. 21…”

Section: Histopathological Examination Of the Lungsmentioning

confidence: 99%

Earthworm extract attenuates silica-induced pulmonary fibrosis through Nrf2-dependent mechanisms

Yang

Wang

et al. 2016

Laboratory Investigation

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Silicosis is an occupational pulmonary fibrosis caused by inhalation of silica (SiO) and there are no ideal drugs to treat this disease. Earthworm extract (EE), a natural nutrient, has been reported to have anti-inflammatory, antioxidant, and anti-apoptosis effects. The purpose of the current study was to test the protective effects of EE against SiO-induced pulmonary fibrosis and to explore the underlying mechanisms using both in vivo and in vitro models. We found that treatment with EE significantly reduced lung inflammation and fibrosis and improved lung structure and function in SiO-instilled mice. Further mechanistic investigations revealed that EE administration markedly inhibited SiO-induced oxidative stress, mitochondrial apoptotic pathway, and epithelial-mesenchymal transition in HBE and A549 cells. Furthermore, we demonstrate that Nrf2 activation partly mediates the interventional effects of EE against SiO-induced pulmonary fibrosis. Our study has identified EE to be a potential anti-oxidative, anti-inflammatory, and anti-fibrotic drug for silicosis.

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Protective effects of methyl palmitate against silica-induced pulmonary fibrosis in rats

Cited by 30 publications

References 42 publications

Cytoprotective potential of tiron and methyl palmitate against acetaminophen-induced acute liver injury

Cytoprotective potential of tiron and methyl palmitate against acetaminophen-induced acute liver injury

Chemical Composition of Essential Oils of Passiflora Edulis F. Flavicarpa Agroindustrial Waste

Earthworm extract attenuates silica-induced pulmonary fibrosis through Nrf2-dependent mechanisms

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