Protective effects of Mangifera indica L. extract, mangiferin and selected antioxidants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice

Modulation of Diabetes and Dyslipidemia in Diabetic Insulin-Resistant Rats by Mangiferin: Role of Adiponectin and TNF-α

“…Mangiferin has been reported to possess antidiabetic (Miura et al 2001b), antioxidant (Sanchez et al 2000), antitumor (Guha et al 1996), antiviral (Yoosook et al 2000) and immunomodulatory activities (Leiro et al 2004). Mangiferin has been shown to have antidiabetic activity in KK/Ay mice, a genetic model of noninsulin-dependent diabetes mellitus (NIDDM) with hyperinsulinemia (Miura et al 2001b).…”

Effects of a natural extract from Mangifera indica L, and its active compound, mangiferin, on energy state and lipid peroxidation of red blood cells

“…Therefore, it is generally regarded as a marker of peroxidative damage induced in cell membranes by both physical and chemical oxidative stresses, rendering its determination in biological samples particularly interesting [44]. Although the inhibitory activity of Vimang and mangiferin on MDA production has been described previously [11,12], its determination in the present work by HPLC technique furnishes more reliability and reproducibility to the obtained results. Nevertheless, these products where studied for the first time in a new context, erythrocytes system, giving another explanation of the beneficial effects of Vimang consumption by patients suffering of oxidative stress.…”

“…Experimental methods were planned and developed in order to measure the antioxidant, free radical scavenging and membrane protecting activities and to monitor the capacity of these natural compounds to reduce the extend of lipid peroxidation. Some previous "in vivo" experiments demonstrated that Vimang is a better scavenger of ROS and a more efficient inhibitor of oxidation tissue damage than vitamin C, vitamin E, β-carotene and mangiferin [12]. Mangiferin, constituting approximately 10% of the whole Vimang extract [13], was also identified as a ROS scavenger.…”

“…Recently, a standard aqueous stem bark extract from selected species of Mangifera indica L. (Anacardiaceae), which has been used in pharmaceutical formulations in Cuba under the brand name of Vimang®, has been reported to show a potent in vivo and in vitro anti-inflammatory activity [8,9], immunomodulation on rat macrophages [10] and a strong in vitro and in vivo antioxidant effect [11,12].…”

“…Different studies demonstrated that mango stem bark extract could be useful to prevent the hyperproduction of reactive oxygen species (ROS) by peritoneal macrophages and from (TPA)-induced oxidative damage in serum, liver, and brain of mice, being more active than vitamin C, vitamin E, and β-carotene [12]. This extract also shows a very powerful scavenger activity for hydroxyl radicals (OH · ) and hypochlorous acid, associated to a relevant inhibitory effect on the peroxidation of rat brain phospholipids and a protective effect against DNA damage induced by iron/bleomycin or copperphenantroline models [11].…”