Tablet Design

Abstract

The compression of powders is a complex task due to the variability in particle size and shape, the unknown distribution of the particles in the die, their different ability to flow, and the forces needed to create bonds between them. In tablet design many factors have to be taken into account, such as the physicochemical properties of active compounds and excipients. This article provides a brief description of the main theoretical aspects of tablet design and formulation together with practical examples of tablet development and characterization using different techniques.