Protective effects of Ligustrum lucidum fruit extract on acute butylated hydroxytoluene-induced oxidative stress in rats

The Effects of Butylated Hydroxyl Toluene on the Total Anti̇oxi̇dant Status/ Total Oxi̇dant Stress and Bi̇ochemi̇cal Parameters in Rats

“…[21] Recent studies show that BHT increases oxidative stress and causes tissue damage. [22][23][24] It has been reported that the toxic effects of BHT may be related to the metabolites causing cellular damage and lipid peroxidation such as BHT peroxyl, quinoxyl and phenoxyl radicals, and that these free radicals formed by BHT impair the hepatic membrane integrity and lead to the leakage of hepatic enzymes into the plasma. [24] High doses of BHT have been related to pneumotoxicity, hepatotoxicity and nephrotoxicity, and leakage of enzymes such as LDH, ALT and AST.…”

“…[4] A single dose of BHT has been reported to cause an increase in serum transaminase activity. [28] Lin et al [23] reported that with an increase in the oxidative stress formed by BHT, there was an increase observed in the serum AST, ALT and LDH activities, and in the levels of cholesterol, Cr, triglyceride and BUN, which was contributed by the investigators to the functional impairing effect of BHT on the liver and kidneys.…”

“…[23] BHT was reported to reduce the activities of plasma catalase (CAT), cholinesterase and peroxidase. [42] Mizutani et al [43] claimed that the hepatotoxic effect of BHT was dose-and time-dependent, that BHT was not proven to cause hepatic damage at a 800 mg/kg dose, and that BHTquinone methide reduced the level of glutathione (GSH) and caused hepatic damage in mice.…”

Ligustrum lucidum Fruits Extract Inhibits Acute Pulmonary Inflammation in Mice

“…(LL, Oleaceae) have been used for protecting kidney and liver, and this plant has been reported to have beneficial effects such as anti-inflammatory, anti-tumor, anti-aging and immunomodulatory activities (Lin et al, 2007). LL contains various compounds such as triterpenes, flavonoids and glucoside (He et al, 2001).…”

Anti-hyperlipidemic activity of spider brake (Pteris multifida) with rats fed a high cholesterol diet

“…In previous studies, it was found that many Taiwanese folk herbs have pharmacological functions such as anti-inflammation, anti-virus, anti-cancer, immune enhancement, antioxidant, anti-aggregation and hepatoprotection (Chang et al, 2005;Hsu et al, 2005;Kuo et al, 2004;Lin et al, 2000Lin et al, , 2002Lin et al, , 2007Lu et al, 2000;Wu et al, 2004;Yang et al, 2005Yang et al, , 2007Yen et al, 2007).…”