Ligustrum lucidum Fruits Extract Inhibits Acute Pulmonary Inflammation in Mice

Abstract

: Traditionally, Ligustrum lucidum fruits (LL) is one of the well-known oriental herb used in the treatment of skin and lung inflammation. This study investigated anti-inflammatory effects of LL in the pathogenesis of acute pulmonary inflammation in mice. Acute pulmonary inflammation was induced by intratracheal instillation of cigarette smoke condensate (CSC) and lipopolysaccharide (LPS) 5 times within 12 days in mice. LL extract was administered orally at a dose of 50 or 200 ㎎/㎏. Administration of LPS and CSC significantly elevated airway hyperresponsiveness (AHR) to mice, and increased in the levels of inflammatory cells and mediators in mice. However, the LL extract significantly reduced the elevated AHR, and the increase of neutrophils, CD4 + /CD3+ cells and CD8 + /CD3 + cells, along with reducing the expression of TNF-α, IL-6, and MIP-2. Moreover, the LL extract alleviated the infiltration of inflammatory cells in expanded airway walls histologically. These results indicate that the LL extract has an inhibitory effects on acute pulmonary inflammation and AHR in murine model, and plays a crucial role as a immunomodulator which possess anti-inflammatory property.

Citrus junos Tanaka Peel Extract and Its Bioactive Naringin Reduce Fine Dust-Induced Respiratory Injury Markers in BALB/c Male Mice

“…To determine whether the administration of CPE and naringin could alleviate PM 10 -induced lung inflammation, mice were subjected to oral administration of CPE and naringin for 7 days; after this, to induce pneumonitis phenotypes, the mice were subjected to intranasal injection of PM 10 (100 mg/kg body weight) at the last day and sacrificed after 6 h. The naringin and low-dose CPE concentration (i.e., 100 mg/kg body weight) were determined on the basis of the work of previous papers using similar samples (i.e., naringin and natural product extracts), and the higher dose of CPE was chosen to confirm the dose-dependent response of CPE [ 11 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. As an initial response against PM 10 , inflammatory immune cells (e.g., eosinophils and neutrophils) are recruited on the site, followed by air space enlargement and detachment, all of which are typical pneumonitis manifestations [ 34 , 35 ].…”

Chemical Constituents From the Fruits ofLigustrum lucidum W.T.Aitonand Their Role on the Medicinal Treatment

“…A variety of pharmacological effects have been reported, such as antiosteoporosis, 44,45 antiviral activity, 46 antioxidation activity, hypoglycemic activity, 47 antitumor activity, 48 apoptosis-inducing activity, 49 and anti-inflammatory activity. 50 It was reported in the literature that the water extract of FLL played a beneficial role in the treatment of lumbar disc herniation. 51 In addition, the FLL extract can increase Na + , K + , and Ca 2+ -ATPase activity, improve the activity of the total nitric oxide synthase in the different tissues of rats, and regulate the activity of antioxidant enzymes in rat heart, thus extending the exercise time to avoid fatigue.…”