The Effects of Butylated Hydroxyl Toluene on the Total Anti̇oxi̇dant Status/ Total Oxi̇dant Stress and Bi̇ochemi̇cal Parameters in Rats

Değer, Yeter

doi:10.20959/wjpps20175-9137

Cited by 1 publication

(1 citation statement)

References 35 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lipid peroxidation is initiated by the mislaying of one hydrogen atom from the chains of unsaturated fatty acid within the membrane structure as a result of ROS synthesized in the organism. The membrane damage perceived as a result of lipid peroxidation is found to be irreversible 50 .…”

Section: Fig 1: Histology Of Investigational Rat Brain Tissue Under L...mentioning

confidence: 99%

Untitled

2023

IJPSR

View full text Add to dashboard Cite

Mercury is the more risky heavy metal for human health because of its ability to kill human nerve cells and its exposure to the environment through human activities, which implicate sewage drainage, agriculture, municipal, mining, incineration, and drainage of industrial wastewater. Mercury and its compounds cause toxic action in the body by several mechanisms, which mainly cause the nervous system through their molecular and cellular effects. The present research intended to investigate the ameliorative potential of betulinic acid and rotundic acid against mercuric chloride (HgCl 2 ) (1.29 mg/kg b. w.) induced neurotoxicity in adult male rats. The examination was implemented in male albino Wistar rats (n = 36). Which was partitioned into six gatherings as follows: Control, HgCl 2 , HgCl 2 + betulinic acid, HgCl 2 + rotundic acid, betulinic acid alone, and rotundic acid alone. The results revealed that intense HgCl 2 regulation modified different biochemical specifications incorporated with the high volume of lipid peroxidation (LPO) portion and a significantly depleted level of reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) pursuits in the brain tissue. Acetylcholinesterase AChE activity in the brain tissue was also brought down in HgCl 2-intoxicated rats. Betulinic acid and rotundic acid is a natural antioxidant that assists in safeguarding oxidative injury by diminishing oxidative stress. In contrast, the treatment of betulinic acid and rotundic acid (5 mg/kg B. W) in the brain tissue reveals a significant reduction in the degree of oxidant level and concurrently an elevated level of antioxidant properties and AChE activity via rehabilitation in brain tissues. Oxidant substance (LPO), AChE activity status, non-enzymatic antioxidant (GSH), and enzymatic antioxidants (GPx, SOD, CAT) reactions were additionally developed close to the normal (control) level when compared with mercury-treated groups.INTRODUCTION: Mercury was poisonous in all forms that regulate cellular function by altering the tertiary and quaternary structure of proteins and binding with sulfhydryl and selenohydryl groups.

show abstract

Section: Fig 1: Histology Of Investigational Rat Brain Tissue Under L...mentioning

confidence: 99%

Untitled

2023

IJPSR

View full text Add to dashboard Cite

show abstract

The Effects of Butylated Hydroxyl Toluene on the Total Anti̇oxi̇dant Status/ Total Oxi̇dant Stress and Bi̇ochemi̇cal Parameters in Rats

Abstract: Background: The aim of this study was to investigate the effects of

Cited by 1 publication

References 35 publications

Untitled

Untitled

Contact Info

Product

Resources

About