Protective effects of<i>Bidens pilosa</i>on hepatoxicity and nephrotoxicity induced by carbon tetrachloride in rats

Pegoraro, Cristiane Martinez Ruiz; Nai, Gisele Alborghetti; Garcia, Leonardo Alves; Serra, Fernanda de Maria; Alves, Juliana Apolônio; Chagas, Pedro Henrique Nahas; Oliveira, Décio Gomes de; Zocoler, Marcos Alberto

doi:10.1080/01480545.2018.1526182

Cited by 13 publications

(6 citation statements)

References 32 publications

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“…B. pilosa effectively protected against the toxic effects of CCl4, due to the biochemical parameters becoming normalized, there was no hepatic inflammation, and the degree of inflammation in the intestinal mucosa decreased in the animals. Combined use (oral and topical) exerted a better protective effect [ 39 ]. Another study also described the anti-inflammatory effects of the aqueous extract obtained from the B. pilosa leaves in a rat model of androgen deficiency-related dry eye disease.…”

Section: Resultsmentioning

confidence: 99%

Immunomodulatory Properties of Natural Extracts and Compounds Derived from Bidens pilosa L.: Literature Review

Rodríguez-Mesa,

Contreras Bolaños,

Mejía

et al. 2023

Pharmaceutics

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Bidens pilosa L. has been used in different parts of the world mainly to treat diseases associated with immune response disorders, such as autoimmunity, cancer, allergies, and infectious diseases. The medicinal properties of this plant are attributed to its chemical components. Nevertheless, there is little conclusive evidence that describes the immunomodulatory activity of this plant. In this review, a systematic search was carried out in the PubMed-NLM, EBSCO Host and BVS databases focused on the pre-clinical scientific evidence of the immunomodulatory properties of B. pilosa. A total of 314 articles were found and only 23 were selected. The results show that the compounds or extracts of Bidens modulate the immune cells. This activity was associated with the presence of phenolic compounds and flavonoids that control proliferation, oxidative stress, phagocytosis, and the production of cytokines of different cells. Most of the scientific information analyzed in this paper supports the potential use of B. pilosa mainly as an anti-inflammatory, antioxidant, antitumoral, antidiabetic, and antimicrobial immune response modulator. It is necessary that this biological activity be corroborated through the design of specialized clinical trials that demonstrate the effectiveness in the treatment of autoimmune diseases, chronic inflammation, and infectious diseases. Until now there has only been one clinical trial in phase I and II associated with the anti-inflammatory activity of Bidens in mucositis.

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Section: Resultsmentioning

confidence: 99%

Immunomodulatory Properties of Natural Extracts and Compounds Derived from Bidens pilosa L.: Literature Review

Rodríguez-Mesa,

Contreras Bolaños,

Mejía

et al. 2023

Pharmaceutics

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“…10 CCl 4 is a hepatophilic toxicant with a strong toxic effect on renal function. 11 Free radicals (e.g., CCl 3 -and CCl 3 O 2 -) are generated after CCl 4 interacts with the liver; these free radicals will enter kidneys via blood circulation and attack phospholipid molecules on the membranes of renal tubules and glomeruli, causing lipid peroxidation reactions and resulting in AKI. 12 Therefore, CCl 4 models are frequently used in experimental studies to explore the pathogenesis of drug-induced renal injury and evaluate the efficacies of anti-renal injury drugs.…”

Section: Discussionmentioning

confidence: 99%

Saturated hydrogen alleviates CCl₄-induced acute kidney injury via JAK2/STAT3/p65 signaling

Zheng

Zhou

2020

J Int Med Res

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This study assessed the protective effects of saturated hydrogen against CCl 4-induced acute kidney injury (AKI) in mice, and investigated signaling pathways activated by exposure to saturated hydrogen. Methods: A mouse model of CCl 4-induced AKI was established; some mice were treated with saturated hydrogen. Levels of cystatin C and kidney injury molecule 1 were determined using enzyme-linked immunosorbent assays. Blood urea nitrogen and serum creatinine were measured on a fully automated biochemical analyzer. Interleukin-8, tumor necrosis factor-a, and interferon-c in serum and kidney tissues were measured using enzyme-linked immunosorbent assays. Malondialdehyde, glutathione peroxidase, and superoxide dismutase in kidney tissues were measured using biochemical kits. Oxidative stress in kidney tissues was analyzed using nitrotyrosine staining. Expression levels of p-JAK2, p-STAT3, and p-p65 signal protein were assayed by immunohistochemistry and western blotting. Results: Compared with untreated mice with CCl 4-induced AKI, mice that were treated with saturated hydrogen exhibited improved renal function and reduced oxidative stress. Moreover, expression levels of p-JAK2, p-STAT3, and p-p65 were significantly reduced in mice treated with saturated hydrogen, compared with expression levels in untreated mice. Conclusions: Treatment with saturated hydrogen can reduce oxidative stress and inflammatory cytokine activation, potentially through inhibition of JAK2/STAT3/p65 signaling, thereby protecting against AKI.

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“…Os flavonoides foram identificados como: hiperosídeo, rutina, maritimetina, quercetina, okanina, iso-okanina, (Yuan et al, 2008). A planta B. pilosa apresentou efeito de proteção oral e tópica, no fígado, no rim e no 88 intestino, contra toxicidade induzida por tetracloreto de carbono, e exerceu atividade antimutagênica em animais (Pegoraro et al, 2021).…”

Section: Atividade Hepatoprotetoraunclassified

Monografias de Plantas Medicinais Brasileiras e Aclimatadas: Volume II

Gilbert¹,

Alves²,

Favoreto³

2022

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O presente volume contém monografias completas de 11 plantas medicinais amplamente empregadas no país, sendo apenas duas exóticas. Nenhuma dessas espécies possui monografia farmacopeica nas seis edições já publicadas da Farmacopeia Brasileira; portanto, é significativa a contribuição desta obra para o desenvolvimento de fitoterápicos, importantes para a Atenção Primária à Saúde, principalmente quando se considera que 82% da população brasileira utiliza produtos à base de plantas medicinais.

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Protective effects ofBidens pilosaon hepatoxicity and nephrotoxicity induced by carbon tetrachloride in rats

Cited by 13 publications

References 32 publications

Immunomodulatory Properties of Natural Extracts and Compounds Derived from Bidens pilosa L.: Literature Review

Immunomodulatory Properties of Natural Extracts and Compounds Derived from Bidens pilosa L.: Literature Review

Saturated hydrogen alleviates CCl₄-induced acute kidney injury via JAK2/STAT3/p65 signaling

Monografias de Plantas Medicinais Brasileiras e Aclimatadas: Volume II

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Protective effects ofBidens pilosaon hepatoxicity and nephrotoxicity induced by carbon tetrachloride in rats

Cited by 13 publications

References 32 publications

Immunomodulatory Properties of Natural Extracts and Compounds Derived from Bidens pilosa L.: Literature Review

Immunomodulatory Properties of Natural Extracts and Compounds Derived from Bidens pilosa L.: Literature Review

Saturated hydrogen alleviates CCl4-induced acute kidney injury via JAK2/STAT3/p65 signaling

Monografias de Plantas Medicinais Brasileiras e Aclimatadas: Volume II

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Saturated hydrogen alleviates CCl₄-induced acute kidney injury via JAK2/STAT3/p65 signaling