Protective effects of betaglucin on myocardial tissue during myocardial infarction in rats and dogs

Abstract

Aim: To test the protective effects of betaglucin, a novel beta-glucan, on models of myocardial infarction (MI) in rats and dogs. Methods: The left anterior descending (LAD) coronary artery occlusion model was used to induce an MI in rats and dogs. Three doses of betaglucin (10, 30 and 100 mg/kg), propranolol (positive control, 1 mg/kg) and vehicle alone (5% glucose solution) were administered before LAD occlusion, and characteristics of the resulting MI were subsequently assessed. In anesthetized dogs, blood pressure, heart rate, ventricular function, coronary artery blood flow and myocardial oxygen consumption were determined before and after the drug administration. Results: The MI mass in both rats and dogs was significantly reduced by betaglucin (30 and 100 mg/kg, P<0.01) and propranolol (P<0.01). In anesthetized dogs, coronary artery blood flow was increased significantly by betaglucin (30 and 100 mg/kg, P<0.01), but blood pressure, heart rate and ventricular function were not changed (P>0.05). High-dose betaglucin (100 mg/kg) increased myocardial oxygen consumption, but not to a statistically significant level (P>0.05). The hemodynamic indexes were significantly changed by propranolol. Conclusion: Betaglucin has protective effects on myocardial tissue during MI in rats and dogs and has no influence on hemodynamic parameters at a therapeutic dose. The increase in coronary artery blood flow induced by betaglucin might be beneficial in the treatment of patients with MI.

Separation, identification and rapid determination of liensine, isoliensinine and neferine from embryo of the seed of Nelumbo nucifera GAERTN. by liquid chromatography coupled to diode array detector and tandem mass spectrometry

“…Isoliensinine has exhibited a significant inhibitory effect on bleomycin-induced pulmonary fibrosis, probably due to its antioxidant and/or antiinflammatory activities and inhibitory over expressing TNF- alpha and TGF-beta(1) induced by bleomycin [11], and exerted antiproliferative effect on coronary arterial smooth muscle cells (CASMCs) induced by phenylephrine [12]. Neferine has been reported to possess a reversal effect of multidrug resistance (MDR) mediated by glutathione (GSH) detoxifcation system in K562/A02 cell line [13], reverse multidrug resistance of human gastric carcinoma SGC7901/VCR cells, which may be associated with the down-regulations of P-gp and MRP expression in SGC701/VCR cells [14], and have greater relaxant effects to rabbit cavernosal muscle stripes precontracted with phenylephine (PE), than the other extracts such as tetrandrine, kakonein, scutellarin, ginsenoside Rgl and ginsenoside Rb1 [15], and cardiovascular pharmacological effects [16].…”

Pretreatment with β‐glucan attenuates isoprenaline‐induced myocardial injury in rats

“…Pretreatment with β‐glucan (50 mg kg −1 day −1 ) for 10 days markedly decreased the ST segment elevation and increased the R‐wave amplitude reduction in ISO‐induced myocardial infarcted rats, which suggests its cell membrane‐protective effects by scavenging free radicals. Likewise, it was reported that both 30 and 100 mg kg −1 of betaglucin, a novel β‐glucan, markedly inhibited the elevation of the ST segment induced by coronary artery ligation in mongrel dogs (Qian et al., ). In the present study, the s.c .…”

The Unexpected Cardioprotection by Epigenetic Foods

“…Flavonoids, such as anthocyanins, are common anti-oxidant compounds of plant-derived functional foods and their regular intake after ischemia-reperfusion injury improves cardiac function in rats [99]. Similar benefits are induced with shortterm oral administration of beta-glucan in a swine model of myocardial ischemia/reperfusion [100] and in a canine model of myocardial infarction [101]. In addition, short-term dietary intake of cooked broccolis can limit the infarct size of murine hearts exposed to ischemia-reperfusion injury [102].…”