Protective effects of a polyphenol-enriched fraction of the fruit peel of Annona crassiflora Mart. on acute and persistent inflammatory pain

Justino, Allisson Benatti; Costa, Mônica Soares; Saraiva, André Lopes; Silva, Pedro Henrique; Vieira, Thiago Neves; Dias, Paulo Eduardo Miamoto; Linhares, Camila Rodrigues Borges; Dechichi, Paula; Ávila, Veridiana de Melo Rodrigues; Espíndola, Foued Salmen; Silva, Cássia Regina

doi:10.1007/s10787-019-00673-7

Cited by 12 publications

(10 citation statements)

References 68 publications

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“…The evaluation of pain using animal models can be questionable. Based on many protocols, thermal hyperalgesia using a hot plate is one method that has been thoroughly validated (22)(23)(24). Chronic pain conditions in animals could be defined as prolonged hyperalgesia shown as a shortening of the latency time toward the thermal stimulus (22,23).…”

Section: Discussionmentioning

confidence: 99%

Red Ginger Oil Affects COX-2 and NMDAR Expression During Inflammatory- or Neuropathy-Induced Chronic Pain in Mice

Fajrin

Hidayanti

Khoiroh

et al. 2021

Jundishapur J Nat Pharm Prod

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Background: Chronic pain treatment until now is still challenging because of its complex pathopgysiology. Previously, red ginger oil (RGO) reduced pain behavior in a mouse model of chronic pain, but the mechanisms were unclear. Objectives: This study examined the effect of RGO on cyclooxygenase (COX)-2 and the N-methyl-D-aspartate receptor (NMDAR) using inflammatory- or neuropathy-induced chronic pain in mice. Methods: Red ginger was distilled with composition 1:2 using water. The acute toxicity of RGO was evaluated using OECD guidelines 423. Chronic pain was induced in 48 mice by either (1) intraplantar injection of complete Freund’s adjuvant (CFA) (inflammatory group) or (2) partial sciatic nerve ligation (PSNL) (neuropathy group). After seven days, mice were randomly divided into sham, CFA/PSNL, or RGO (at doses of 100, 200, 400, or 600 mg/kg) treatment groups. Treatments were given orally once daily until day 14. On day 15, mice were euthanized, and the brains and spinal cords were removed and fixed in 10% formalin. Hyperalgesia behavior was evaluated using hot plate test. Spinal cord morphology was analyzed via hematoxylin and eosin staining. COX-2 and NMDAR expressions were evaluated by immunohistochemistry. Results: RGO treatment improved spinal cord morphology after the induction of chronic pain. RGO at 600 mg/kg also reduced COX-2 expression in the spinal cord and brain, and reduced NMDAR2B in the spinal cord. However, RGO at 600 mg/kg increased NMDAR2A expression in the spinal cord. Conclusions: RGO administration diminished hyperalgesia in chronic pain models through inhibition of COX-2 and NMDAR2B.

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Section: Discussionmentioning

confidence: 99%

Red Ginger Oil Affects COX-2 and NMDAR Expression During Inflammatory- or Neuropathy-Induced Chronic Pain in Mice

Fajrin

Hidayanti

Khoiroh

et al. 2021

Jundishapur J Nat Pharm Prod

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“…Daily intake of whole araticum pulp (3.214 mL/kg bw) for 30 days promoted a significant reduction in the total leukocytes of rats as compared to the control group [ 57 ]. Justino et al [ 56 ] evaluated the effect of different ethanolic extract fractions from araticum peel on pro-inflammatory mediators’ production in an LPS-induced macrophage model. Only phenolic-rich fractions (ethyl acetate (0.1 and 0.3 µg/mL) and n -butanol (1 µg/mL) fractions) reduced LPS-stimulated IL-6 and NO production.…”

Section: Biological Activities Reported In Araticum Fruit Partsmentioning

confidence: 99%

Scientific Advances in the Last Decade on the Recovery, Characterization, and Functionality of Bioactive Compounds from the Araticum Fruit (Annona crassiflora Mart.)

Arruda

Borsoi

Andrade

et al. 2023

Plants

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Araticum (Annona crassiflora Mart.) is a native and endemic species to Brazilian Cerrado whose fruits have high sensorial, nutritional, bioactive, and economic potential. Its use in local folk medicine, associated with recent scientific findings, has attracted growing interest from different industrial sectors. Therefore, understanding the scientific advances achieved so far and identifying gaps to be filled is essential to direct future studies and transform accumulated knowledge into innovative technologies and products. In this review, we summarize the phytochemical composition, bioactivities, and food products from araticum fruit that have been reported in the scientific literature over the past 10 years. The compiled data showed that araticum fruit parts contain a wide range of bioactive compounds, particularly phenolic compounds, alkaloids, annonaceous acetogenins, carotenoids, phytosterols, and tocols. These phytochemicals contribute to different biological activities verified in araticum fruit extracts/fractions, including antioxidant, anti-inflammatory, anti-Alzheimer, anticancer, antidiabetic, anti-obesity, antidyslipidemic, antinociceptive, hepatoprotective, healing of the cutaneous wound, antibacterial, and insecticide effects. Despite the promising findings, further studies—particularly toxicological (especially, with byproducts), pre-clinical, and clinical trials—must be conducted to confirm these biological effects in humans and assure the safety and well-being of consumers.

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“…The structural diversity of flavonoids results in a wide range of biological effects; the different substitutions on the carbon atoms determine the biological effects of the flavonoids [18]. It has been reported that flavones show different pharmacological actions, such as antinociceptive [19], anti-inflammatory [20], antioxidant [21], antiulcerogenic [22], and anticarcinogenic [23] actions. The combination of multiple pharmacological properties in a single nucleus is quite interesting [16].…”

Section: Introductionmentioning

confidence: 99%

Potential Therapeutic Anti-Inflammatory and Immunomodulatory Effects of Dihydroflavones, Flavones, and Flavonols

et al. 2020

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Systemic inflammation, circulating immune cell activation, and endothelial cell damage play a critical role in vascular pathogenesis. Flavonoids have shown anti-inflammatory effects. In this study, we investigated the effects of different flavonoids on the production of pro-inflammatory interleukin (IL) 1β, 6, and 8, and tumor necrosis factor α (TNF-α), in peripheral blood cells. Methods: We studied the whole blood from 36 healthy donors. Lipopolysaccharide (LPS)-stimulated (0.5 μg/mL) whole-blood aliquots were incubated in the presence or absence of different concentrations of quercetin, rutin, naringenin, naringin, diosmetin, and diosmin for 6 h. Cultures were centrifuged and the supernatant was collected in order to measure IL-1β, TNF-α, IL-6, and IL-8 production using specific immunoassay techniques. This production was significantly inhibited by quercetin, naringenin, naringin, and diosmetin, but in no case by rutin or diosmin. Flavonoids exert different effects, maybe due to the differences between aglycons and glucosides present in their chemical structures. However, these studies suggest that quercetin, naringenin, naringin, and diosmetin could have a potential therapeutic effect in the inflammatory process of cardiovascular disease.

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Protective effects of a polyphenol-enriched fraction of the fruit peel of Annona crassiflora Mart. on acute and persistent inflammatory pain

Cited by 12 publications

References 68 publications

Red Ginger Oil Affects COX-2 and NMDAR Expression During Inflammatory- or Neuropathy-Induced Chronic Pain in Mice

Red Ginger Oil Affects COX-2 and NMDAR Expression During Inflammatory- or Neuropathy-Induced Chronic Pain in Mice

Scientific Advances in the Last Decade on the Recovery, Characterization, and Functionality of Bioactive Compounds from the Araticum Fruit (Annona crassiflora Mart.)

Potential Therapeutic Anti-Inflammatory and Immunomodulatory Effects of Dihydroflavones, Flavones, and Flavonols

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