Protective effect of α- and β-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. trunk wood resin, against acetaminophen-induced liver injury in mice

Oliveira, Francisco de Assis; Chaves, Mariana Helena; Almeida, Fernanda Campos Sousa de; Lima, Roberto César Pereira; Silva, Regilane M.; Maia, Juliana L.; Brito, Gerly Anne A.C.; Santos, Flávia Almeida; Rao, V. S. N.

doi:10.1016/j.jep.2005.01.036

Cited by 142 publications

(78 citation statements)

References 25 publications

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“…Lupeol, a triterpene, when co-administered with APAP, effectively reduces oxidative stress and prevents APAP-induced hepatotoxicity by inhibiting critical control points of apoptosis (Kumari & Kakkar, 2012). One study also indicated the protective effect of a-and b-amyrin, a triterpene mixture from the trunk wood resin, against APAP-induced liver injury in mice through modulating the oxidative stress/antioxidant parameters (Oliveira et al, 2005). The protective effects of quercetin and curcumin on APAP-induced liver injury in rat through mitigation the rise in TBARS and restored the activities of antioxidant enzymes were also reported (Yousef et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Protective effects of IranianAchillea wilhelmsiiessential oil on acetaminophen-induced oxidative stress in rat liver

Dadkhah

Fatemi

Alipour

et al. 2014

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 99%

Protective effects of IranianAchillea wilhelmsiiessential oil on acetaminophen-induced oxidative stress in rat liver

Dadkhah

Fatemi

Alipour

et al. 2014

Pharmaceutical Biology

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“…Its stalk exudes an oily resin called almecega or breu-branco, which hardens on contact with air, of white-greenish color, pleasant aroma and rich in essential oils (Lorenzi & Matos, 2008). Contraceptive, antineoplastic, healing, expectorant and antimicrobial action were also related others authors (Oliveira et al 2005, Rüdiger et al 2007.…”

Section: Introductionmentioning

confidence: 76%

“…Phytochemical studies performed on gums and oil resin, obtained from P. heptaphyllum revealed the presence of binary mixtures of triterpenes, especially α-and β-amyrins (Susunaga et al 2001, Oliveira et al 2005. The chemical constituents of essential oil of this resin analyzed by gas chromatography-mass spectroscopy (GC/MS) are mainly monoterpenes (Bandeira et al 2001, Citó et al 2003, but, phenylpropanoids were also identified in the product (Siani et al 1999a).…”

Section: Introductionmentioning

confidence: 99%

MDGC-MS analysis of essential oils from Protium heptaphyllum (Aubl.) and their antifungal activity against Candida specie

Mobin

Lima

Almeida

et al. 2016

Rev. bras. plantas med.

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Protium heptaphyllum is found in the Amazon region, and in various Brazilian states and South American countries. Also Known as almecega, it produces an oil resin used in traditional medicine as analgesic, anti-inflammatory, cicatrizant and expectorant, it is rich in pentacyclic triterpenes and essential oil. The main objective of this study was to analyze the chemical composition of P. heptaphyllumresin (OEPh) over different extraction times and to evaluate their antifungal activity against Candida species, obtained from gardeners with onychomycosis, using the disk diffusion method. The OEPh was obtained by hydrodistillation and analyzed by Multidimensional Gas Chromatography coupled with Mass Spectrometry (MDGC / MS). Candida species were obtained from lesions on the nails of horticulturist from a community garden in the city of Teresina, Piauí, Brazil. The antifungal activity in concentrations of 1000 µg/L, 500 µg/L and 250 µg/L, PROTOCOL M44-A2 (CLSI 2009) OEPh was tested. The main constituents identified were: l-limonene, α-terpineol, p-cineol, o-cymene and α-phellandrene, however, its composition varies significantly with extraction time. All species, except C. rugosa, were inhibited with halo (≥ 14 mm) at 1000 μg / L. C. krusei is naturally resistant to the drug fluconazole, but when tested with OEPh the clinical species (case 9) demonstrated sensitivity in three dilutions (halo ≤ 10 ≥ 14) and the standard strain was inhibited at concentration of 1000 μg/Lg / L (halo 14mm). A similar situation also occurred with the standard strain of C. parapsilosis (halo ≥ 11mm). OEPh has considerable antifungal activity, which merits further investigation for alternative clinical applications, since this species is widely distributed in our community, and it presents good yields, and also has important therapeutic applications.

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“…Despite results showing that use value for the plant set is not related with its environmental availability, this may be detected for some species (Ferraz et al, 2006). Besides, P. heptaphyllumis frequently cited by different populations for several types of use (Pasa, Soares, & Guarim-Neto, 2004, Cunha & Albulquerque, 2006, Crepaldi & Peixoto, 2010, also being reported its use in pharmacology (Oliveira et al, 2005, Aragão et al, 2006. This species presents wide distribution in Brazil (Daly, 2014) abundant species on restinga (Assumpção & Nascimento, 2000, Assis et al, 2004.…”

Section: Resultsmentioning

confidence: 99%

<b>Useful woody species and its environmental availability: the case of artisanal fishermen in Itaúnas, Brazil

Lopes

Crepaldi

Lobão

2017

Acta Sci. Biol. Sci.

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ABSTRACT. Ethnobotanical studies involve research with human societies and their different interaction with plants, and the quantitative approaches from thes estudies are important to select conservation priority of species in natural environment. This research aims to quantify use-values for woody plants mentioned by fishers in Itaúnas, state of Espírito Santo, and evaluate the relationship between use-values and species availability (absolute density and frequency, and importance value) in two distinct resting vegetation formations. It also proposes to identify priority species for conservation. It was selected 30 species cited in individual semi-structured interviews with key-informant in fishers' community and who were also on list of structural survey of two vegetation phytophysiognomies in the restinga regions. The data used was collected in previously published work. It was performed a correlation analysis between use-values and structural parameters of the mentioned woody species. Protium heptaphyllum, P. icicariba and Byrsonima sericea present the highest use-values. It was not observed relation between use-value and species availability in each vegetation formation. It was classified two and eight species as priority for conservation on shrubby and forest formations, respectively.Keywords: structural characteristics, ethnobotany, Itaúnas State Park, restinga, use-value (UV).Espécies lenhosas úteis e sua disponibilidade no ambiente: o caso dos pescadores artesanais em Itaúnas, Brasil RESUMO. Estudos etnobotânicos envolvem pesquisas com sociedades humanas e suas diferentes interações com as plantas, e abordagens quantitativas deste estudos são importantes para selecionar prioridades de conservação das espécies nos ambientes naturais. Esta pesquisa objetiva quantificar os valores de uso das plantas citadas por pescadores em Itaúnas, Espírito Santo, e avaliar as relações entre os valores de uso a disponibilidade das espécies (densidade e frequência absoluta e valor de importância) em duas formações vegetais distintas de restinga. É também proposto identificar o índice de prioridade de conservação das espécies. Foram selecionadas 30 espécies citadas em entrevistas individuais semiestruturadas com informantes-chave na comunidade de pescadores e que também estavam em listas de levantamentos estruturais de duas fitofisionomias vegetais de restinga na região. Os dados utilizados foram coletados em trabalhos previamente publicados. Foi feita a análise de correlação entre os valores de uso e os parâmetros estruturais das espécies lenhosas mencionadas. Protium heptaphyllum, P. icicariba e Byrsonima sericea apresentaram o maior valor de uso. Não foi observado relação entre o valor de uso a disponibilidade das espécies em cada formação vegetal. Foram classificadas duas e oito espécies para prioridade de conservação nas formações arbustivas e florestais respectivamente.Palavras-chave: características estruturais, etnobotânica, Parque Estadual de Itaúnas, restinga, valor de uso.

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Protective effect of α- and β-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. trunk wood resin, against acetaminophen-induced liver injury in mice

Cited by 142 publications

References 25 publications

Protective effects of IranianAchillea wilhelmsiiessential oil on acetaminophen-induced oxidative stress in rat liver

Protective effects of IranianAchillea wilhelmsiiessential oil on acetaminophen-induced oxidative stress in rat liver

MDGC-MS analysis of essential oils from Protium heptaphyllum (Aubl.) and their antifungal activity against Candida specie

<b>Useful woody species and its environmental availability: the case of artisanal fishermen in Itaúnas, Brazil

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