Protective effect of zinc supplementation on blood antioxidant defense system in rats exposed to cadmium

Jemai, Hedya; Messaoudi, Imed; Chaouch, A.; Kerkeni, Abdelhamid

doi:10.1016/j.jtemb.2007.08.001

Cited by 88 publications

(73 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Findings in spite of the further accumulation of Cd in the liver and kidney. In fact, in recent studies, Zn has been demon strated to play an important rule in preventing the oxidative stress, apoptosis and necrosis induced by Cd [9,[51][52][53].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Zinc (Zn) on the Histology and Histochemistry of Liver and Kidney of Albino Rat Treated with Cadmium

Mahran¹,

Osman²

2011

J Cytol Histol

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Protective Effect of Zinc (Zn) on the Histology and Histochemistry of Liver and Kidney of Albino Rat Treated with Cadmium

Mahran¹,

Osman²

2011

J Cytol Histol

View full text Add to dashboard Cite

“…The study was designed considering that (1) the EU limit of Cd in feed is 5 mg/kg (EC, 2005), (2) in some cases levels of Cd in feed can exceed maximum permitted limits (Li et al, 2010a), (3) the addition of elevated levels of essential elements may ameliorate the negative effects of toxic metal contamination (Nolan and Brown, 2000;Jemai et al, 2007;Jihen et al, 2008) and (4) the maximum allowed Se inclusion level in the United States is 0.3 mg/kg (Payne et al, 2005).…”

Section: Animals Diets and Experimental Designmentioning

confidence: 99%

“…Several studies investigated ways to reduce Cd toxicity by administering other elements as a remedy (Jemai et al, 2007;Jihen et al, 2008), as absorption, accumulation and toxicity of a trace element may be affected by a variety of factors, including the element's level in feed ingredients, its chemical form, ability to form complexes and interactions with other elements (Valko et al, 2005;Lopez-Alonso et al, 2007;Pappas et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

The role of organic selenium in cadmium toxicity: effects on broiler performance and health status

Al-Waeli

Zoidis

Pappas

et al. 2013

Animal

View full text Add to dashboard Cite

This work was part of a project designed to assess whether organic selenium (Se) can protect against the toxic effects of cadmium (Cd). A total of 300 1-day-old, as hatched, broilers were randomly distributed in four dietary treatments with five replicate pens per treatment. In T1 treatment, broilers were fed a diet with 0.3 mg/kg added Se, as Se-yeast, without added Cd; in T2, broilers were fed a diet with 0.3 mg/kg Se and 10 mg/kg Cd; in T3, broilers were fed a diet with 0.3 mg/kg Se and 100 mg/kg of Cd; and in T4 treatment broilers were fed a diet with 3 mg/kg Se and 100 mg/kg Cd. The Cd was added to diets T2, T3 and T4 as CdCl 2 . On the 4th and 6th week, two broilers per replicate pen were killed in order to obtain whole blood, liver, kidney and breast samples. Body mass, feed conversion ratio and mortality were assessed and haematological analyses were performed. Se and Cd levels in tissues were analysed by inductively coupled plasma mass spectrometry. Broilers supplemented with 0.3 mg/kg Se can tolerate low levels of Cd added to the diets, as there were no significant negative effects on the examined performance parameters, whereas addition of excess Cd led to an impairment of broilers' performance. Mortality of broilers did not differ between the four dietary treatments at any interval point or the whole period. The examined haematological parameters such as haematocrit, total blood protein concentration, and leukocytes types ranged within physiological values, revealing no negative health effects after simultaneous Cd and Se addition. The present study indicated that Se can help against the negative effects of Cd, but cannot counteract all of its negative effects.

show abstract

“…Zinc supplementation may inhibit ROS generation, and enhance the activity of antioxidant pathways (Zhou et al, 2005). Furthermore, Zn participates in cell membrane stabilization, metallothionein (Mt) synthesis and Cu-Zn SOD structure (Jemai et al, 2007), and, when added to the diet of healthy humans, may reduce concentrations of oxidative stress (Prasad et al, 2007). It remains unclear, however, whether Zn protects the testis from heat-induced oxidative damage.…”

Section: Introductionmentioning

confidence: 99%

Dietary zinc may attenuate heat-induced testicular oxidative stress in mice via up-regulation of Cu-Zn SOD

Cao

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Zinc (Zn) is important for male mammalian reproduction. In this study, we sought to clarify the role of Zn in heat-induced testicular damage in mice. Eighteen mice were divided into either control (con), heat (heat) and heat plus Zn (H+Zn) treatment groups, and fed diets containing 60 (con and heat groups) or 300 (H+Zn group) mg/kg Zn sulfate for one month. Mice in the con group were then maintained at 25°C, while mice in heat and H+Zn groups were exposed to 40°C for 2 h daily, for eight days. Mouse testes and serum from each animal were analyzed. Zinc levels in serum and testes were positively correlated to Zn feed concentrations. Mice in the heat group had higher testes index than those in the other two groups (7.22 ± 0.75, heat; 4.92 ± 0.20, con; 4.80 ± 0.30 mg/g, H+Zn; P < 0.05). Testicular antioxidant status showed malondialdehyde levels in heat group mice were increased compared to control mice (2.34 ± 0.15 versus 1.55 ± 0.23 nmol/mg protein; P < 0.05), and Cu-Zn superoxide dismutase (SOD) level differed between heat and H+Zn groups (14.04 ± 0.74 versus 18.27 ± 1.53 U/mg protein; P < 0.05). Testicular Cu-Zn SOD protein expression levels were significantly lower in the heat than in the control 16617 Zinc attenuates heat-induced testicular oxidative stress ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 16616-16626 (2015) group (0.30 ± 0.11 versus 1.22 ± 0.13; P < 0.05). These results suggest that dietary Zn may elevate the activity and protein concentration of Cu-Zn SOD, to attenuate testicular oxidative stress induced by heat exposure.

show abstract

Protective effect of zinc supplementation on blood antioxidant defense system in rats exposed to cadmium

Cited by 88 publications

References 39 publications

Protective Effect of Zinc (Zn) on the Histology and Histochemistry of Liver and Kidney of Albino Rat Treated with Cadmium

Protective Effect of Zinc (Zn) on the Histology and Histochemistry of Liver and Kidney of Albino Rat Treated with Cadmium

The role of organic selenium in cadmium toxicity: effects on broiler performance and health status

Dietary zinc may attenuate heat-induced testicular oxidative stress in mice via up-regulation of Cu-Zn SOD

Contact Info

Product

Resources

About