Protective Effect of Zinc (Zn) on the Histology and Histochemistry of Liver and Kidney of Albino Rat Treated with Cadmium

Mahran, Alsayed Ali; Osman, Husam Eldien Husien

doi:10.4172/2157-7099.1000123

Cited by 9 publications

(5 citation statements)

References 41 publications

(52 reference statements)

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“…This is in agreement with many authors who reported the toxicity of Cd on the liver [24][25][26][27]. Mahran et al [28] found that the Cd can cause vacuolar degeneration and increased density of nuclear chromatin with very compact nuclear structure found in hepatocytes. In addition to mononuclear cell infiltrations and necrosis of single cells were also observed.…”

Section: Discussionsupporting

confidence: 92%

Effect of Cadmium on the Liver and Amelioration by Aqueous Extracts of Fenugreek Seeds, Rosemary, and Cinnamon in Guinea pigs: Histological and Biochemical Study

Albasha¹,

Azab²

2014

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Hepatotoxic agents can react with the basic cellular components and consequently induce almost all types of liver lesions. Objective: The present work aimed to evaluate effectiveness of fenugreek seeds, rosemary and cinnamon against cadmium induced hepatotoxicity in guinea pigs from the histological and biochemical aspects. Materials and methods: 48 guinea pigs were used for this study and divided into 8 groups. The first 4 groups were control groups, the 5 th group was the experimental and administered oral cadmium chloride at a dose of 5 mg/kg. body weight./day for 28 days, the 6 th , 7 th , and 8 th groups co-administered cadmium with aqueous extracts of fenugreek seeds, rosemary and cinnamon at a dose of 150 mg, 220 mg, and 200 mg/ kg body weight /day, respectively. The livers were dissected out, weighted and specimens were taken and processed for light microscopic examinations. Blood samples were obtained for assessment of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, γ-glutamyltransferase activities, and serum total and direct bilirubin. Results: In cadmium treated animals, there were severe structural damage in the liver. Most of hepatocytes appeared fused together forming eosinophilic syncytial masses. The hepatocytes appeared irregularly arranged with disorganization of hepatic architecture. The hepatocytes appeared large with light and foamy cytoplasm filled with numerous vacuole-like spaces. The nuclei appeared with pyknotic nuclei. The central vein appeared dilated and congested with massive hemorrhage extending to the nearby cells. Mild periductal fibrosis around bile duct in the portal area were observed. Also, there were focal degenerative and necrotic changes along with inflammatory cell infiltration. Decrease in body weight and increase in liver weight were observed. Biochemically, the serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase), and γ-glutamyltransferase activities, serum total and direct bilirubin were elevated. Co-adminstration of fenugreek, rosemary and cinnamon significantly improved the structural changes in the liver and also all the above mentioned biochemical parameters were significantly declined. Conclusion: It can be concluded that, the cadmium had adverse effects on the liver. Aqueous extracts of different natural materials as Fenugreek, rosemary and cinnamon were able to attenuate these effects. So, the populations of high risk to cadmium should be advised to take one of these materials.

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Section: Discussionsupporting

confidence: 92%

Effect of Cadmium on the Liver and Amelioration by Aqueous Extracts of Fenugreek Seeds, Rosemary, and Cinnamon in Guinea pigs: Histological and Biochemical Study

Albasha¹,

Azab²

2014

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“…This also might be explained according to the ethanol-induced metabolic failure especially to ATP production which directs the switch in pathway to apoptosis or necrosis as reported by a previous study [58]. Furthermore, the results of the present study were parallel to some previous authors who studied apoptosis and the protective effects of zinc against forebrain ischemia [59], sporidesmininduced apoptosis in macrophages and T lymphoblasts [60], cadmiuminduced hepatotoxicity and nephrotoxicity [61] and even against radiation lethality in mice [62].…”

Section: Discussionsupporting

confidence: 87%

Histopathological and Histochemical Assessment of the Protective Effects of Zinc on Ethanol-Induced Acute Hepatotoxicity in Adult Albino Rats

Elshennawy¹,

Sayed²,

Saber³

et al. 2015

J Cytol Histol

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“…The attack of the organic components of the cells (lipids, proteins or carbohydrates) allows the transmission of the radical character and thus triggers severe pathologies up to the death of the animals (Mahran et al 2011). It has been reported that subchronic oral exposure of nickel leads to multiple liver necrosis associated with changes in ultrastructure and hepatic changes (Bulat et al 2008;El Refaiy and Eissa 2012).…”

Section: Figurementioning

confidence: 99%

Hepatoprotective effect of Zinc and Magnesium against subchronic Cadmium toxicity on biochemical, histopathological and neurobehavioral parameters in Wistar rats

Kouadria

Djemli

Tahraoui

2020

JABB

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The aim of this study was carried out to investigate the possible hepato protective effect of Zinc and Magnesium against subchronic cadmium toxicity on biochemical, histopathological and neurobehavioral parameters in Wistar rats during 90 days. Fourty Wistar rats, were randomly divided in four experimental group: 1, control only water; 2, water and oral administration (Cd); 3, (Cd+Mg) in water oral administration; 4, (Cd+Zn) in water oral administration. Zinc and Magnesium was used to reduce hepatoxicity and neurobehavioral disorders induced by Cadmium in Wistar rats. The Cd-Zn and Cd-Mg groups received 10 mg/kg of ZnCl2, 10 mg/kg of MgCl2 added to drinking water. The Cd group received 15mg / kg of CdCl2. Blood glucose level and body weight were measured every day. According to the results, which have been obtained. There was a reduction in body weight gain due to Cd group and an increase liver weight. The results indicated also changes in biochemical parameters, which are characterized by an increase in serum glucose, serum urea, serum creatinine, of animals contaminated with cadmium compared to the control animals. However, the supplementation of (Zn) and Mg combination improved some but not all the previous parameters. Moreover, the findings showed variation in hematological parameters of Cd treated animals. In other word, there was a rise in number of white cells, and reduction of red cells counts, hemoglobin concentration and hematocrit percentage, but all these parameters returned approximately to their normal values after combined Zn and Mg addition. The neurobehavioral test shows an increase in the number of cells crossed, the number of straightening in the test. Open field in the group exposed to Cd resulting in locomotors hyperactivity compared to the control and it is minimal in other groups treated with Zn and Mg. On the other hand, the elevated plus maze (EPM) revealed an increase of the time spent in the closed arms of the cadmium group compared to the control. The results clearly showed also deteriorations of liver structure tissue in comparison with the controls, including extensive degeneration of hepatocytes with necrosis, inflammation, the presence of cellular debris within a central vein and cytological vacuolization. The present investigation indicated that Cd had toxicity effects on the previous mentioned parameters. However, the supplementation of combined Zn and Mg was ameliorated some of these parameters and reduced liver histological alterations caused by Cd toxicity.

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Protective Effect of Zinc (Zn) on the Histology and Histochemistry of Liver and Kidney of Albino Rat Treated with Cadmium

Cited by 9 publications

References 41 publications

Effect of Cadmium on the Liver and Amelioration by Aqueous Extracts of Fenugreek Seeds, Rosemary, and Cinnamon in Guinea pigs: Histological and Biochemical Study

Effect of Cadmium on the Liver and Amelioration by Aqueous Extracts of Fenugreek Seeds, Rosemary, and Cinnamon in Guinea pigs: Histological and Biochemical Study

Histopathological and Histochemical Assessment of the Protective Effects of Zinc on Ethanol-Induced Acute Hepatotoxicity in Adult Albino Rats

Hepatoprotective effect of Zinc and Magnesium against subchronic Cadmium toxicity on biochemical, histopathological and neurobehavioral parameters in Wistar rats

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