Protective effect of vitamin C against chlorpyrifos oxidative stress in male mice

Aly, Nagat M.; El‐Gendy, K.S.; Mahmoud, Fatma; El-Sebae, Abdel Khalek H.

doi:10.1016/j.pestbp.2009.11.007

Cited by 105 publications

(58 citation statements)

References 27 publications

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“…Wherever in groups treated by malathion plus vitamine c or malathion plus green tea there were a significant decrease of them when compared with malathion group, these observations agree with those of Ayo et al (2006) and Ambali et al (2010), who reported that vitamin c is an effective antioxidant in various biological systems. The reduction may be due to the protective effects of vitamin c have been reported previously by other investigators (Aly et al, 2010) and green tea decreased renal degeneration and caused disappearance of cortical necrosis in kidney tissues. This protection may be attributed to phosphorylation and activation of endothelial nitric oxide syntheses in endothelial cells through modulation of protein kinase C. A signaling pathways by green tea resulting in endothelial dependant vasorelaxtion (Lorenz et al, 2004).…”

Section: Discussionsupporting

confidence: 69%

Protective Role of Vitamin C and Green Tea Extract on Malathion-Induced Hepatotoxicity and Nephrotoxicity in Rats

Elzoghby¹,

Hamoda²,

Aboubakr³

et al. 2014

American Journal of Pharmacology and Toxicology

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The present study was designed to determine the modulating effect of green tea and vitamin C against adverse effects of malathion. Animals were divided into four groups 5 rats /group). Group one was used as a control. Group two given malathion (50 mg/kg/day; 1/50 of the LD50 for four weeks). Group three and Group four were given malathion (50 mg/kg/day; 1/50 of the LD50 for four weeks) plus vitamin C (200 mg/kg/day) and plus green tea (36 mg/kg/day) respectively. At the end of the fourth week, the malathion-treated group had significantly lower Red Blood Cell count (RBCs), Hemoglobin concentration (Hb), Packed Cell Volume (PCV%) and leucocytes (WBCs) than the control group. Compared to the control group, the malathion-treated group had significantly higher serum Alkaline Phosphatase (ALP), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Lactate Dehydrogenase (LDH), urea, creatinine and uric acid levels than the control group. The malathion treated rats also had significantly lower serum total protein, albumin and globulin levels than the control group, but the malathion plus vitamin C and malathion plus green tea groups did not differ from the control group in terms of these parameters. Moreover, concomitant vitamin C and green tea treatment significantly normalized, at least partially, all of the other hematological and biochemical parameters that were altered by malathion. Liver tissue homogenate in malathion treated group had lower Glutathione (GSH), Glutathione Peroxidase (GSH-PX) and Superoxide Dismutase (SOD) levels accompanied with higher level of Malondialdehyde (MDA) than the control group. Histopathological studies revealed that the malathion-treated, malathion plus vitamin C and malathion plus green tea treated groups exhibited histopathological changes in liver and kidney tissues, although some pathological features were only observed in the malathion-treated group. Thus, vitamin C and green tea can reduce malathion hepatotoxicity and nephrptoxicity.

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Section: Discussionsupporting

confidence: 69%

Protective Role of Vitamin C and Green Tea Extract on Malathion-Induced Hepatotoxicity and Nephrotoxicity in Rats

Elzoghby¹,

Hamoda²,

Aboubakr³

et al. 2014

American Journal of Pharmacology and Toxicology

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“…This is similar to what Aly et al [32], Surajudeen et al [33] reported when mice and farmers were exposed to pesticides respectively.…”

Section: Discussionsupporting

confidence: 89%

Evaluation of Oxidative Stress Biomarkers and Atherogenic Indices in Adult Wistar Rats Exposed to Pyrethroid Insecticides

Atere¹,

Osadolor²

2017

Am. J. Biomed. Sci.

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Indiscriminate use of pesticides appears to increase the production of free radicals in organisms such as humans and other animals. Thus, the aim of this study was to investigate the effect of pyrethroid insecticides on oxidative stress biomarkers and atherogenic indices in exposed adult Wistar rats. A total number of apparently healthy 60 Wistar rats were randomly selected for this study and divided into two groups. Thirty six (36) were exposed to 1.2 % w/v pyrethroid insecticides while the remaining twenty four (24) were grouped as non-exposed. The animals in each group were anesthetized and blood sample was collected from the inferior vena cava after days of exposure. Plasma levels of total antioxidant status (TAS), malondialdehyde (MDA), glutathione (GSH), hydrogen peroxide (H 2 O 2 ), Nitric Oxide (NO) and lipids profiles were determined using standard spectrophotometric techniques. Plasma activities of superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) were determined using standard spectrophotometric techniques. Statistical analysis of data was obtained and P<0.05 was considered significant. The mean TChol and HDL were significantly higher in 7days than 41days exposure, while plasma mean TChol and HDL were significantly lower in 41days than 21days exposure. The plasma mean levels of SOD, GPx, CAT, GSH and TAS were significantly decreasing while plasma mean levels of MDA, H 2 O 2 and NO were significantly increasing from 7 days through 41 days exposure in exposed groups irrespective of the gender. In conclusion, this study observed that there is oxidative stress in Wistar rats exposed to pyrethroids based insecticides and lowered antioxidant defenses also observed in the studied population. Also, there was increased in weight differences with possibility of becoming obese. Thus, antioxidant supplements are advised as a prophylactic supportive therapy for adequate measures in preventing development of oxidative stress-associated complications among exposed individuals.

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“…Водночас, за даними різних авторів [1,2,3], �� може індукувати виникнення оксидаційного стресу. �е явище супроводжується значною кількістю актив� них форм оксигену (А��), які не можуть бути утилізовані відповідними системами клітини і спричиняють окисні модифікації ліпідів, про� теїнів, нуклеїнових кислот.…”

Section: Abstract: Chlorpyrifos Vitamin E Vitamin a Red Blood Cellunclassified

“…�і результати узгоджуються з дани� ми літератури [5]. За даними Ambali et al [1], за оксидаційного стресу має місце зростання вмісту �БК�активних продуктів, що призво� дить до порушень антиоксидантного статусу та змін активності клітинних ензимів.…”

Section: результати й обговоренняunclassified

Effect of 5-day exposure of vitamin A and E on status of red blood cell antioxidant system and hematological parameters of rats intoxicated by chlorpyrifos

Rosalovsky¹

2017

Bìol. Tvarin

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Protective effect of vitamin C against chlorpyrifos oxidative stress in male mice

Cited by 105 publications

References 27 publications

Protective Role of Vitamin C and Green Tea Extract on Malathion-Induced Hepatotoxicity and Nephrotoxicity in Rats

Protective Role of Vitamin C and Green Tea Extract on Malathion-Induced Hepatotoxicity and Nephrotoxicity in Rats

Evaluation of Oxidative Stress Biomarkers and Atherogenic Indices in Adult Wistar Rats Exposed to Pyrethroid Insecticides

Effect of 5-day exposure of vitamin A and E on status of red blood cell antioxidant system and hematological parameters of rats intoxicated by chlorpyrifos

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