Protective effect of turmeric extract on ethotrexate-induced intestinal damage and oxidative stress

Moghadam, Adel Rezaei; Mohajeri, Daryoush; Namvaran-Abbas-Abad, Ali; Manafi, Hamed; Shahi, Delavar; Mazani, Mohammad

doi:10.1016/s1875-5364(13)60087-4

Cited by 10 publications

(8 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increased levels of MDA and MPO, and decreased levels of tGSH, GSHRd, GSHPx, CAT and SOD in the rats given MTX in the present study confirm the results of Kolli et al [13]. Moghadam et al reported that MTX leads to oxidative stress in rat small intestine by increasing the amount of MDA and decreasing activities of some enzymatic antioxidants such as SOD, GSHPx and CAT [18]. …”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Effects of nimesulide on the small intestine mucositis induced by methotrexate in rats

et al. 2016

View full text Add to dashboard Cite

Intestinal mucositis is one of the major problems in the patients receiving cancer treatment. Nimesulide is a drug with antioxidant, antiinflammatory and antiulcer features. We aimed to investigate the effect of nimesulide on the small intestine mucositis induced by methotrexate (MTX) in rats. Experimental animals were divided into the control group, MTX group (MTXG) and nimesulide+MTX administered group (NMTXG) with eight rats per group. The control and MTXG groups were given distilled water by gavage and the NMTXG was given nimesulide 100 mg/kg orally. After one hour, the NMTXG and MTXG rat groups were administered oral MTX 5 mg/kg. This procedure was repeated once a day for 15 days and the rats were sacrificed. The duodenum and jejunum of each rat was removed for the assessment of biochemical markers and histopathological evaluation. Malondialdehyde (MDA) and myeloperoxidase (MPO) levels were significantly higher in the duodenal and jejunal tissues of the animals which received MTX, compared to the control and NMTXG (P<0.001). Also, the levels of total glutathione (tGSH), glutathione reductase (GSHRd), glutathione peroxidase (GSHPx), catalase (CAT) and superoxide dismutase (SOD) were significantly lower in the MTXG (P<0.001) compared to other groups. MTX led to villus and crypt epithelial damage and inflammation containing marked PMNL and eosinophils in the intestinal tissues histopathologically. Whereas, there was only mild irregularities in the villus structures of the NMTXG. Nimesulide protected the small intestines against damage by MTX. Intestinal mucositis caused by MTX may be preventable by co-administered nimesulide.

show abstract

Section: Discussionsupporting

confidence: 90%

“…In another study, MTX has been reported to lead to the cellular loss, severe villus atrophy and PMNL leukocyte infiltration [7]. In addition to these histopathological findings, MTX is known to cause intestinal hemorrhage [18]. Some studies emphasize that MTX creates more severe damage in the jejunum than in the duodenum [17, 25].…”

Section: Discussionmentioning

confidence: 99%

Effects of nimesulide on the small intestine mucositis induced by methotrexate in rats

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In addition, it has been reported that erythema and atrophy in the epithelium arises due to inflammatory cell infiltration and capillary vessel proliferation in mucositis [46,47]. Oxidant levels are high and antioxidant levels are low in the bowel tissue, and any smoothening was monitored in the villus epithelium [46]. In our study, the smoothening that was observed in the villus epithelium reflects the atrophy of epithelial cells.…”

Section: Discussionsupporting

confidence: 52%

“…Mildly dilated congested capillaries were also found in the jejunum of the HR50+Cis group. Moghadam et al histopathologically showed that hemorrhage developed in the oxidative bowel damage induced by the chemotherapy [46]. In addition, it has been reported that erythema and atrophy in the epithelium arises due to inflammatory cell infiltration and capillary vessel proliferation in mucositis [46,47].…”

Section: Discussionmentioning

confidence: 99%

“…Moghadam et al histopathologically showed that hemorrhage developed in the oxidative bowel damage induced by the chemotherapy [46]. In addition, it has been reported that erythema and atrophy in the epithelium arises due to inflammatory cell infiltration and capillary vessel proliferation in mucositis [46,47]. Oxidant levels are high and antioxidant levels are low in the bowel tissue, and any smoothening was monitored in the villus epithelium [46].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Hippophae rhamnoides extract on oxidative mucosal injury induced by cisplatin in rat jejunum

Arslan¹,

Özçıçek²,

Çimen³

et al. 2018

biomedicalresearch

View full text Add to dashboard Cite

Objectives: We aimed to assess the effect of Hippophae rhamnoides extract (HR) on oxidative stress induced by cisplatin (Cis) in rat small intestine tissue by evaluating the biochemical and gene expression levels and histopathological changes. Materials and methods: The control group and Cis group received distilled water, while the HR25+cisplatin (HR25+Cis) group and the HR50+cisplatin (HR50+Cis) group were given HR 25 and 50 mg/kg, respectively, orally for seven days. HR25+Cis, HR50+Cis, Cis groups were injected with a single dose of intraperitoneal cisplatin on the first day. After sacrifice, the jejunum of each rat was removed for the assessment of oxidants and antioxidants. Analyses of the gene expression (for IL-1ß and TNF-α) and histopathological changes evaluated. Results: HR significantly inhibited the increase of oxidants and the decrease of antioxidants caused by cisplatin in the jejunal tissue. IL-1β and TNF-α gene expression levels were almost the same in both the HR50+Cis and the control groups. HR better prevented increase of the serum levels of IL-1β and TNF-α in animals at 50 mg/kg dose compared to 25 mg/kg dose. We confirmed that HR prevented the histopathological changes caused by cisplatin. Conclusions: It was concluded that oxidative stress caused by cisplatin may be preventable by coadministered HR.

show abstract

Turmeric ethanolic extract possesses stronger inhibitory activities on colon tumour growth than curcumin – The importance of turmerones

Yue

Jiang

Kwok

et al. 2016

Journal of Functional Foods

View full text Add to dashboard Cite

Protective effect of turmeric extract on ethotrexate-induced intestinal damage and oxidative stress

Cited by 10 publications

References 24 publications

Effects of nimesulide on the small intestine mucositis induced by methotrexate in rats

Effects of nimesulide on the small intestine mucositis induced by methotrexate in rats

Effects of Hippophae rhamnoides extract on oxidative mucosal injury induced by cisplatin in rat jejunum

Turmeric ethanolic extract possesses stronger inhibitory activities on colon tumour growth than curcumin – The importance of turmerones

Contact Info

Product

Resources

About