Turmeric ethanolic extract possesses stronger inhibitory activities on colon tumour growth than curcumin – The importance of turmerones

Yue, Grace Gar-Lee; Jiang, Lei; Kwok, Hin‐Fai; Lee, Julia Kin-Ming; Chan, K. C. Allen; Fung, Kwok‐Pui; Leung, Ping‐Chung; Lau, Clara Bik‐San

doi:10.1016/j.jff.2016.02.011

Cited by 35 publications

(25 citation statements)

References 38 publications

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“…DMCC and BDMCC at the same concentration reduced proliferation of A549 cells to approximately 60% of control levels (IC 50 > 10 μg/ml); in contrast to the total extract, which displayed 70% inhibition of cancer cell viability (Figure ). Our findings are consistent with previous studies showing that DMCC or BDMCC are more efficient in blocking cancer cell growth than curcumin (Basile et al, ; Thapliyal & Maru, ; Yodkeeree, Chaiwangyen, Garbisa, & Limtrakul, ; Yue et al, ).…”

Section: Resultssupporting

confidence: 93%

Superior anticancer activity is demonstrated by total extract of Curcuma longa L. as opposed to individual curcuminoids separated by centrifugal partition chromatography

Kukuła-Koch

Grabarska

Łuszczki

et al. 2018

Phytotherapy Research

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Three curcuminoids: bisdemethoxycurcumin, demethoxycurcumin, and curcumin from turmeric were successfully separated by a high capacity solvent system composed of heptane: chloroform: methanol: water mixture (5: 6: 3: 2 v/v/v/v) tailored for centrifugal partition chromatographs at K-values of 0.504, 1.057, 1.644, respectively. These three ferulic acid derivatives obtained at a purity rate exceeding 95% were analysed by an HPLC-MS spectrometer. Turmeric extract inhibited the proliferation/viability of A549 human lung cancer, HT29 colon cancer, and T98G glioblastoma cell lines in (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay (MTT). Single curcuminoids significantly decreased the viability/proliferation of lung cancer cells in a dose-dependent manner. However, total extract displayed the superior anticancer activity in the investigated cell lines. Crude extract in combination with cisplatin augmented the decrease in the viability of cancer cells compared with single compound treatment in A549 lung cancer cells. Total extract of Curcuma longa could be regarded as being more effective against lung cancer cells in vitro than its separated compounds.

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Section: Resultssupporting

confidence: 93%

Superior anticancer activity is demonstrated by total extract of Curcuma longa L. as opposed to individual curcuminoids separated by centrifugal partition chromatography

Kukuła-Koch

Grabarska

Łuszczki

et al. 2018

Phytotherapy Research

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“…Some research suggests that whole food extracts can be more effective than isolated compounds [ 37 , 38 , 39 ], and the present study clearly demonstrates the potential benefits of CHS, individually and in combination, in relation to CRC. The IC 50 s established using the SRB and MTT assays as GAE and DW equivalents clearly show that the action of these CHS is likely due to their polyphenolic constituents and not the amount of the CHS used, as their potency in IC 50 expressed as μg GAE/mL differs from those expressed as per gram of dry weight.…”

Section: Discussionsupporting

confidence: 69%

Inhibitory Effects of Culinary Herbs and Spices on the Growth of HCA-7 Colorectal Cancer Cells and Their COX-2 Expression

et al. 2017

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It is unclear if the anti-inflammatory properties of culinary herbs and spices (CHS) are linked to their ability to inhibit Colorectal cancer cell (CRC) growth. Furthermore, their therapeutic potential with regards to CRC is unknown. The aim of this study was to establish if the inhibition of HCA-7 CRC cell growth by a selection of culinary herbs and spices (CHS) is linked to the inhibition of the cells’ cyclooxygenase-2 (COX-2 )expression, and to investigate their therapeutic potential. CHS inhibited the growth of Human colon adenocarcinoma-7 (HCA-7) cells; the order of potency was turmeric, bay leaf, ginger, sage, and rosemary; their combinations had a synergistic or additive effect on cell growth inhibition. CHS also inhibited COX-2 expression and activity; this action was comparable to that of the specific COX-2 inhibitor Celecoxib. Coincident with COX-2 inhibition was the accumulation of cells in the sub G1 phase of the HCA-7’s cell cycle and, using bay leaf and turmeric, the cleavage of caspase 3 and poly (ADP-ribose) polymerase (PARP). This latter effect showed that the effect of these CHS on growth arrest was irreversible, and was comparable to that of the caspase activator Etoposide. This study provides evidence of a link between the inhibition of HCA-7 growth, and its COX-2 expression, by CHS, and their therapeutic potential.

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“…Ar-turmerone can be used as a potential anti-angiogenic agent 78 . Yue et al 79 also demonstrated the enhancement of antiproliferative and anti-angiogenic activities of CUR in the presence of turmerones in human colon cancer cells and endothelial cells respectively. The superior anti-tumor effects of turmeric extract, which contains CUR, turmerones and other constituents were verified in tumor bearing mice, indicating the potential use of turmeric for colorectal cancer adjuvant therapy.…”

Section: Biological Activities Of Curcuminoidsmentioning

confidence: 99%

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Amalraj¹,

Pius

Gopi

et al. 2017

Journal of Traditional and Complementary Medicine

708

413

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In recent years, several drugs have been developed deriving from traditional products and current drug research is actively investigating the possible therapeutic roles of many Ayruvedic and Traditional Indian medicinal therapies. Among those being investigated is Turmeric. Its most important active ingredient is curcuminoids. Curcuminoids are phenolic compounds commonly used as a spice, pigment and additive also utilized as a therapeutic agent used in several foods. Comprehensive research over the last century has revealed several important functions of curcuminoids. Various preclinical cell culture and animals studies suggest that curcuminoids have extensive biological activity as an antioxidant, neuroprotective, antitumor, anti-inflammatory, anti-acidogenic, radioprotective and arthritis. Different clinical trials also suggest a potential therapeutic role for curcuminoids in numerous chronic diseases such as colon cancer, lung cancer, breast cancer, inflammatory bowel diseases. The aim of this review is to summarize the chemistry, analog, metal complex, formulations of curcuminoids and their biological activities.

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Turmeric ethanolic extract possesses stronger inhibitory activities on colon tumour growth than curcumin – The importance of turmerones

Cited by 35 publications

References 38 publications

Superior anticancer activity is demonstrated by total extract of Curcuma longa L. as opposed to individual curcuminoids separated by centrifugal partition chromatography

Superior anticancer activity is demonstrated by total extract of Curcuma longa L. as opposed to individual curcuminoids separated by centrifugal partition chromatography

Inhibitory Effects of Culinary Herbs and Spices on the Growth of HCA-7 Colorectal Cancer Cells and Their COX-2 Expression

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

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