Protective effect of Trigonella foenum-graecum on thioacetamide induced hepatotoxicity in rats

Abstract

Trigonella foenum-graecum belongs to the family Fabaceae and is indigenous to countries that lie on the eastern shores of the Mediterranean Sea and is also cultivated in India, Egypt and Africa. This study provides the evidence indicating the therapeutic effect of the extract prepared from the dried seeds of Trigonella foenum-graecum on an animal model of hepatotoxicity and on cell proliferation. Rats were induced liver cirrhosis by thioacetamide (0.03% in water for 16 weeks). Transmission electron microscopy of the liver tissue was done to evaluate liver cirrhosis. The herbal extract was administered orally for 3 weeks after induction and biochemical estimations were done. After the administration of extract the oxidative stress and lipid peroxidation were reversed. The elevated levels of alkaline phosphatase, γ-glutamyl transferase and selected biochemical markers of liver cirrhosis including drug metabolizing enzymes were also reversed. The study has implications in finding a treatment for liver cirrhosis by a natural herbal drug with no side effects.

Isolation and identification of flavonoids from anticancer and neuroprotective extracts of <i>Trigonella foenum</i> graecum

“…In the present study, it was revealed that the oral administration of NaNO 2 for 15 days induced neuronal damage in the mice brain, as indicated by histopathological examination compared to the control group. Our findings are consistent with the earlier studies carried out to determine the negative effects of NaNO 2 on cell membrane by inhibiting membrane bound enzymes in rat brain [14]. Current findings suggest that T. foenum graecum extracts can inhibit the neurodegeneration in brain hippocampus and cortex.…”

Effect of Thyme and Rosemary on Liver Functions in Toxicated Rats by Aflatoxins

“…The present outcomes demonstrate a significant increase in AST, ALT and ALP because of aflatoxin infusion. Rise of liver catalysts was as per that revealed by many examinations (Salama et al, 2013;Zargar, 2014 andKim et al, 2014). Sherif et al, (2009) indicated that liver enzymes increased after liver damage because of increased membrane permeability or because of liver cell necrosis and cytosol leakage into the serum.…”

The use of medicinal plants in venous ulcers: a systematic review with meta‐analysis

“…Clinical trials were included if they had evaluated the healing of venous ulcers with the topical use of herbal medicines. Studies that evaluated ulcer healing with the use of herbal medicines in animals , ulcers with other etiologies , cost‐benefit and reporting cases were excluded .…”