Isolation and identification of flavonoids from anticancer and neuroprotective extracts of &lt;i&gt;Trigonella foenum&lt;/i&gt; graecum

Ahmed, Shabina Ishtiaq; Hayat, Muhammad Qasim; Zahid, Saadia; Tahir, Muhammad; Mansoor, Qaisar; Ismail, Muhammad; Keck, Kristen; Bates, Robert B.

doi:10.4314/tjpr.v16i6.25

Cited by 18 publications

(9 citation statements)

References 19 publications

(16 reference statements)

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“…MEPC and ascorbic acid exhibited a concentration-dependent radical-scavenging activity where 49.06% and 97.05% highest scavenging activity was observed by 500 µg/mL dose of ascorbic acid and MEPC, respectively. Phenolic compounds scavenge free radicals and release hydrogen atoms and electrons to exhibit antioxidant capacity [65] The phenolic substances are effective in intervening neurodegenerative diseases, where the flavonoids reported to studied for preventing the neurodegeneration [66,67]. In quantitative phytochemical analysis, the total phenol content (TPC) of the MEPC was demonstrated as 118.31 ± 1.12 GAE/g of extract which was calculated from the calibration curve (y = 0.0039x + 0.0406; R 2 = 0.9981).…”

Section: Effect Of Methanol Extract Of P Calocarpa On Antioxidant Acmentioning

confidence: 99%

Deciphering the Pharmacological Properties of Methanol Extract of Psychotria calocarpa Leaves by In Vivo, In Vitro and In Silico Approaches

et al. 2020

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The present study explores the neuropharmacological, antinociceptive, antidiarrheal, antioxidant, thrombolytic and cytotoxic activity of methanol extract of Psychotria calocarpa leaves (MEPC). In anxiolytic activity testing of MEPC by elevated plus maze test, hole–board test and light–dark test, the extract exhibited a dose-dependent reduction of anxiety while the open field test observed a decreased locomotion. The administration of MEPC revealed a significant dose-dependent reduction of depressant behavior in forced swimming and tail suspension test. Additionally, the antinociceptive and antidiarrheal activity exposed a significant reduction of nociception and diarrheal behavior at the highest dose. In addition, a strong antioxidant activity was observed in DPPH-free radical-scavenging assay (IC50 = 461.05 μg/mL), total phenol content (118.31 ± 1.12 mg) and total flavonoid content (100.85 ± 0.97 mg). The significant clot–lysis activity was also observed with moderate toxicity (LC50 = 247.92 μg/mL) level in the lethality assay of brine shrimp. Moreover, in silico molecular docking study showed that the compound Psychotriasine could offer promising active site interactions for binding proteins. Furthermore, ADME/T and toxicological properties of the compound satisfied the Lipinski’s rule of five and Veber rules for drug-like potential and toxicity level. Overall, MEPC had a potential neuropharmacological, antinociceptive, antidiarrheal and antioxidant activity that warranted further investigation.

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Section: Effect Of Methanol Extract Of P Calocarpa On Antioxidant Acmentioning

confidence: 99%

Deciphering the Pharmacological Properties of Methanol Extract of Psychotria calocarpa Leaves by In Vivo, In Vitro and In Silico Approaches

et al. 2020

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“…One new leptoisoflavone A (a rare 5-membered dihydrofuran ring) from Limonium leptophyllum [79], 2,2′-trimethoxy-6,8-dihydroxy-isoflavone from the ethanol extract of Thespesia populnea bark [80] and isoflavones, genistein and daidzein from Hericium erinaceum (Figure 9) [81]. from aerial parts of Chenopodium album [84], amurensin and cosmosiin from Trigonella foenum graecum [85], rhamnosides flavonol, kaempferol-3-O-rhamnoside and quercetin-3-O-rhamnoside from leaves of Pometia pinnata [86] and a new flavonol glycoside, sabiapside A from Sabia parviflora [87] (Figure 10).…”

Section: Isoflavonoidsmentioning

confidence: 99%

Biosynthesis of Diverse Class FlavonoidsviaShikimate and Phenylpropanoid Pathway

Rehan¹

2021

Biosynthesis [Working Title]

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Flavonoids are natural products, which are useful in the protection of various types of human diseases. Several bioactive flavonoids as chalcones, flavonols, flavanol, flavones, flavanone, flavan, isoflavonoids, and proanthocyanidin, are found in parts as leaves, root, bark, stem, flowers, weed, fruits of plant species. Flavonoids are synthesized in higher plant species via the shikimate pathway, phenylpropanoid and polyketide pathway. The chalcones and flavanones are central intermediates of the pathway, which give several diverse classes of flavonoids. Central intermediates pathway (chalcones and flavanones pathway) depends on plants species and group of enzymes such as hydroxylases, reductases and isomerases to give different classes of flavonoids skeleton. The anthocyanins, isoflavonoids and condensed tannin (proanthocyanidins) are an important class of flavonoids, which synthesized by flavanones. Mostly, biosynthesis of flavonoids start from phenylpropanoid pathway. The phenylpropanoid pathway starts from shikimate pathway. The shikimate pathway starts from phosphoenol pyruvate and erythrose 4-phosphate.

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“…The potential of flavonoids for preventing neurodegeneration has been widely studied. One group reported the investigated action of amurensin and cosmosiin, flavonoids isolated from Trigonella foenum extracts against NaNO 2 -induced neurodegeneration in mice brains, proving the potential of these compounds to inhibit neurodegeneration in the hippocampus and cortex regions [136]. Moreover, proanthocyanidins, a class of natural flavonoids, proved to mitigate rotenone-induced oxidative stress in human neuroblastoma SH-SY5Y dopaminergic cells, a model for Parkinson’s disease [137].…”

Section: Antioxidants For Neuroprotectionmentioning

confidence: 99%

Antioxidant Therapies for Neuroprotection—A Review

Teleanu

Chircov

Grumezescu

et al. 2019

JCM

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Although moderate concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are crucial for various physiological processes within the human body, their overproduction leads to oxidative stress, defined as the imbalance between the production and accumulation of ROS and the ability of the body to neutralize and eliminate them. In the brain, oxidative stress exhibits significant effects, due to its increased metabolical activity and limited cellular regeneration. Thus, oxidative stress is a major factor in the progressive loss of neurons structures and functions, leading to the development of severe neurodegenerative disorders. In this context, recent years have witnessed tremendous advancements in the field of antioxidant therapies, with a special emphasis for neuroprotection. The aim of this paper is to provide an overview of the oxidative stress and antioxidant defense mechanisms and to present the most recent studies on antioxidant therapies for neuroprotection.

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Isolation and identification of flavonoids from anticancer and neuroprotective extracts of <i>Trigonella foenum</i> graecum

Cited by 18 publications

References 19 publications

Deciphering the Pharmacological Properties of Methanol Extract of Psychotria calocarpa Leaves by In Vivo, In Vitro and In Silico Approaches

Deciphering the Pharmacological Properties of Methanol Extract of Psychotria calocarpa Leaves by In Vivo, In Vitro and In Silico Approaches

Biosynthesis of Diverse Class FlavonoidsviaShikimate and Phenylpropanoid Pathway

Antioxidant Therapies for Neuroprotection—A Review

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