Effect of Thyme and Rosemary on Liver Functions in Toxicated Rats by Aflatoxins

Abstract

Thyme and rosemary assume a part in hepatoprotectivity and go about as anti-aflatoxicosis. This examination has endeavored to explore impact of subacute measurements of aflatoxin in rats and conceivably to foresee any advantages or disadvantages of thyme and rosemary. Thirty adult male albino rats were partitioned into five groups. Rats were isolated into two main groups, the first main group (n=6 rats), negative control, was fed on basal diet. The second main group was inebriated with Aflatoxin then was divided into four subgroups as follow, the first subgroup was kept as positive control group, sub groups (2 and 3) were fed on basal diet and supplemented with thyme and rosemary at of 5% individually. The fourth subgroup was fed on basal diet and supplemented with a combination of 2.5% thyme and 2.5% rosemary. The results indicated that, supplementation with Thyme, Rosemary and their mixes altogether significantly (P<0.05) enhanced liver functions and also serum protein parameters (albumin, globulin and total protein), serum CAT, SOD and decrease significantly MDA compared to the positive control. Furthermore Thyme, Rosemary and their blend significantly decreased (P<0.05) the mean level of serum TNF-α and IL-1-β contrasted with the positive control gathering. The present examination prescribed utilizing Thyme, Rosemary and their blends to shield the body from aflatoxin danger.

Efficacy of Mycotoxin Detoxifiers on Health and Growth of Newly-Weaned Pigs under Chronic Dietary Challenge of Deoxynivalenol

“…Plant compositions (milk thistle, rosemary, licorice, and boldo) in CYB may reduce inflammation by decreasing tumor necrosis factor-alpha and, thus, increasing cell viability in vitro [66]. Particularly, rosemary or its extract have the proven ability to reduce oxidative stress, and inflammatory and immune activation, besides improving liver function under mycotoxin challenge [67,68]. Additionally, αand β-D-glucans, as components of the yeast cell wall, may modulate immune function and selectively interact with the gut microbiome [69].…”

Protective effects of Selenium nanoparticles and thyme extract in detoxification the toxic effects of aflatoxin B1 in rabbits

“…Similar results in our study were obtained in the thyme extracts treated group, where, the histological hepatocyte necrosis of aflatoxicated rabbits was significantly repaired in form of mild necrosis. These benefits of thyme were detected in several studies as (Lin et al, 2009;Esmail, 2018;Nazarizadeh et al, 2019) who recorded their potentials against inflammations of aflatoxicosis and prevention the liver cells necrosis and cause tissue restoration. They added that these effects were dose-dependent, where; the low concentrations prevent cell cirrhosis, while higher levels of thyme extracts resulted in apoptosis and fibrosis.…”

“…Whereas, the thyme extracts are known antioxidant materials which have similar activity as a-tocopherol and other biological antioxidants (Lee and Shibamoto, 2002). Moreover, the administration of thyme compounds improves the adverse effects that resulted from aflatoxicosis, where, they prevent oxidative damage and oxidative stress as (lipid peroxidation which is associated with liver cells cancer (Esmail, 2018;Nazarizadeh et al, 2019).These effects due to their contents of thymol and Phenolic compounds which have antioxidant activity (El-Nekeety et al, 2011;El-Sherbeny et al, 2021).…”