Protective effect of silymarin and ascorbic acid in valproic acid-induced hepatic toxicity in male albino Rats

Ibrahim, Mahrous A.; Abdel-Karim, Rehab I.; Tamam, Hany Goda; Mohamed, Asmaa K.; Wani, Farooq Ahmed

doi:10.21608/mjfmct.2018.47251

Cited by 7 publications

(8 citation statements)

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“…This structure interacts with the cell membrane, causing toxic effects. As an indicator of this toxicity in the cell membrane, it causes an increase in by-products such as BUN and Cr (Ibrahim et al, 2017). In our study, serum Cr and BUN levels increased as a biochemical evidence of kidney damage in VPA treatment.…”

Section: Discussionsupporting

confidence: 54%

Investigation of the effects of silymarin on valproic acid-induced kidney damage in rats

Aktaş¹,

Bayram²

2020

Harran Üniversitesi Veteriner Fakültesi Dergisi

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In this study; we aimed to investigate the protective effects of silymarin (SLY) against kidney damage on valproic acid (VPA)-induced rats using histological and biochemical evaluations. Experimental procedures were performed on 21 male Sprague Dawley rats. Rats were divided randomly into three groups: group 1, control; group 2, VPA; group 3, VPA+SLY. The control group was given 1 mL 0.9 % NaCl orally for 14 days. The VPA group was given 500 mg/kg/day VPA per os for 14 days. The VPA+SLY group was given 500 mg/kg/day VPA and 100 mg/kg/day SLY per os for 14 days. SLY treatment decreased the levels of creatinine (Cr) and blood urea nitrogen (BUN) levels significantly (p < 0.05). In addition, increased amount of thiobarbitüric acid reactive substance (TBARS) and decreased levels of glutathione (GSH) with VPA were significantly suppressed by SLY in kidney tissue (p < 0.05). Histologically, the extent of kidney damage was remarkably lower in the VPA+SLY group (p < 0.005). In addition, VPA+SLY group had decreased oxidative stress, increased antioxidant activity and decreased histopathological changes compared to VPA group. This study revealed that the kidney damage induced by VPA was attenuated with SLY administration. SLY can protect rat kidney against VPA induced damage via anti-oxidative effect and might be useful for reducing the severity of kidney injuries.

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Section: Discussionsupporting

confidence: 54%

Investigation of the effects of silymarin on valproic acid-induced kidney damage in rats

Aktaş¹,

Bayram²

2020

Harran Üniversitesi Veteriner Fakültesi Dergisi

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“…Bilirubin was assessed to evaluate hepatocyte conjugation and excretory functions and was found to be significantly increased after administration of SV, supporting the findings of other studies [44,45] .…”

Section: Discussionsupporting

confidence: 84%

Evaluation of Dose Related Structural Changes in Sodium-Valproate-Induced Hepatotoxicity and a Possible Protective Role of Vitamin E in Adult Albino Rats

Abdel-Kareem

Tawfeek

2019

Egyptian Journal of Histology

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Background: Sodium valproate (SV) is a widely administered antiepileptic drug, although hepatotoxicity is a side effect. Vitamin E (vit. E) being a potent antioxidant agent and essential fat-soluble nutrient that can dramatically decreased this hepatotoxic effect. Aim of the Work:To investigate the histopathological and ultrastructural changes caused by different doses of SV, observe their correlations with liver biomarker levels and assess the defensive role of vit. E against SV-hepatotoxicity. Methods: Sixty male adult albino rats were randomly divided into six groups. Group 1 was treated with normal saline. Group 2 was treated orally with vit. E (100 mg/kg/day). Groups 3, 4 and 5 were treated intraperitoneally with SV at doses of 100, 300 and 500 mg/kg/day, respectively, for 8 consecutive days. Group 6 was treated intraperitoneally with SV (500 mg/kg/ day) and orally with vit. E (100 mg/kg/day) for 8 consecutive days. On the ninth day, blood samples were collected to assess the biochemical markers of the liver, and the results were statistically analysed. The rats were deeply anaesthetized and sacrificed. Liver specimens were carefully dissected, and portions were fixed in 10% formalin solution for histopathological examination; others were fixed in 2.5% glutaraldehyde for ultrastructural study. Results:The liver function among the different groups was found to be significantly changed in dose dependent manner. Histopathological examination showed gradual distortion of hepatic lobular architecture and infiltration of lymphocytic cells. Concerning hepatocyte ultrastructure, SV was a destructive compound for most intracellular organelles. This toxicity was most obvious in the groups treated with higher doses; however, concurrent administration of vit. E with SV provided some hepatoprotection. Conclusion:SV is a destructive compound to the liver architecture, especially in high doses. However, SV damage can be attenuated by concurrent administration of vit. E, which considerably decreases most SV-induced hepatotoxicity.

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“…This is in accordance with our results in group 4 (Silymarin plus C.citratus stem infusion) when compared to group 2. 23 Nouf Al-Rasheed investigated the interaction of Silymarin with chlorogenic acid and melatonin, both of which are important components of C. citratus. His work showed that there existed a synergistic effect between Silymarin, Chlorogenic acids and Melatonin which decreased the serum levels of AST and ALT markedly and also attenuated oxidative DNA damage , apoptosis and fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Hepato curative effects of Silymarin and Cymbopogoncitratus stem infusion: RCT

Mumal¹,

Azeem²,

Zafar³

et al. 2021

PJMHS

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People all around the world suffer from liver diseases, which is a serious health problem. Purpose: To observe the synergistic effects of Silymarin and Cymbopogoncitratus stem infusion on liver in acetaminophen induced hepatotoxicity in rats. Study Design: Laboratory-Based Randomized Control Trial. Methodology: Total forty adult rats were divided into four groups (10 each). Group 1 was taken as control group. After initial sampling at day 0, Acetaminophen (300 mg/kg) was injected to 30 rats via intra-peritoneal route. At day 8, rats were further divided into three groups. Group 2 was a disease control group. Group 3 was given Silymarin (100 mg/kg) and group 4 was treated with Silymarin (100 mg/kg) plus Cymbopogoncitratus stem infusion (130 mg/kg) through gavage method for fourteen days. At day 21, rats were sacrificed for histological examination after terminal sampling. Statistical Analysis: Mean± SEM was calculated and analyzed through SPSS 20. P-value less than 0.05 was considered statistically significant. Results: Rats from group 2 showed marked elevation (p<0.05) in serum markers. There was marked sinusoidal dilatation and necrosis present in group 2 rats.Silymarinin group 3 and Silymarin plus Cymbopogoncitratus stem infusion in group 4 significantly lowered the biochemical enzymes as well as considerably reversed the histological changes in comparison to group 2 rats. Conclusion: We concluded in present study that synergism was observed in group 4 rats. There was more reversal of hepatic injury in group 4 rats. Key words: Cymbopogoncitratus, Silymarin and Synergism.

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Protective effect of silymarin and ascorbic acid in valproic acid-induced hepatic toxicity in male albino Rats

Cited by 7 publications

References 0 publications

Investigation of the effects of silymarin on valproic acid-induced kidney damage in rats

Investigation of the effects of silymarin on valproic acid-induced kidney damage in rats

Evaluation of Dose Related Structural Changes in Sodium-Valproate-Induced Hepatotoxicity and a Possible Protective Role of Vitamin E in Adult Albino Rats

Hepato curative effects of Silymarin and Cymbopogoncitratus stem infusion: RCT

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