Protective Effect of Naringenin Against Lead-Induced Oxidative Stress in Rats

Abstract

Oxidative stress is thought to be involved in lead-induced toxicity. The aim of this study was to investigate the possible protective role of naringenin on lead-induced oxidative stress in the liver and kidney of rats. In the present investigation, lead acetate (500 mg Pb/L) was administered orally for 8 weeks to induce hepatotoxicity and nephrotoxicity. The levels of hepatic and renal markers such as alanine aminotransferase, aspartate aminotransferase, urea, uric acid, and creatinine were significantly (P < 0.05) increased following lead acetate administration. Lead-induced oxidative stress in liver and kidney tissue was indicated by a significant (P < 0.05) increase in the level of maleic dialdehyde and decreased levels of reduced glutathione, superoxide dismutase, catalase, and glutathione peroxidase. Naringenin markedly attenuated lead-induced biochemical alterations in serum, liver, and kidney tissues (P < 0.05). The present study suggests that naringenin shows antioxidant activity and plays a protective role against lead-induced oxidative damage in the liver and kidney of rats.

Evaluation of the Role of Glutathione in the Lead-Induced Toxicity in Saccharomyces cerevisiae

“…3b). These results suggested a reduction of intracellular GSH in Pb-exposed yeast cells, which is in agreement with the data presented in the literature, that describe a GSH decrease in kidney, liver and brain cells of rats exposed to lead [5,24]. It is known that several metals including Hg, Cd and Pb present high affinity to thiol group [14].…”

Cardio protective effects of Nigella sativa oil on lead induced cardio toxicity: Anti inflammatory and antioxidant mechanism

“…Lead is capable of inducing oxidative damage to brain, heart, kidneys and reproductive organs (Daniel et al, 2004;Gholamhosseini et al, 2009;Wang et al, 2012) and the results of this study support the hypothesis; since there were a significant increase in the level of MDA and a significant decrease in the endogenous antioxidants in the cardiac tissue following intake of lead acetate. This was explained by the high affinity of lead for SH group in several enzymes such as SOD, GSH and GPx; thus it can alter antioxidant activities by inhibiting functional SH groups in these enzymes as these enzymes are potential targets of lead toxicity (Marchlewicz et al, 2007).…”

The Ameliorative Effect of Naringenin on Paraquat-Induced Toxicity in Mitochondria Isolated from Rats

“…One possible explanation for PQ-induced mitochondrial dysfunction is that the mitochondrial antioxidant system is ineffective at detoxifying the relevant ROS (28). NG has active flavonoids that can react with superoxide anion radicals or with hydroxyl radicals that act as radical scavengers (13). Our results showed a significant increase in ROS genera- LPO was measured using TBA-reactive substances.…”

“…The potent antioxidant activity of naringenin (NG) (4', 5, 7-trihydroxy-flavonone-7-rhamnoglucoside) makes it a candidate for use in counter-acting the damage induced by oxidative stress (12). NG is a well-known flavonoid found in grapefruit, tomatoes, and citrus fruit (13). NG has a wide spectrum of pharmacological properties, including potential anticarcinogenic, antimutagenic, nephroprotective, hepatoprotective, and antiatherogenic activities (14).…”