Background: Paraquat (PQ) is a dipyridyl herbicide that sustains damage due to redox cycling. An important aspect of PQ toxicity is defined by its interactions with mitochondria. Objectives: This study was designed to evaluate the ability of naringenin (NG) to prevent PQ-induced mitochondrial dysfunction in rat-isolated liver mitochondria.
Materials and Methods:To determine the IC50 of PQ , the mitochondrial viability was specified using an MTT assay. Different concentrations of PQ (0, 2.5, 5, and 10 mM) were used, and the IC50 of PQ was assigned as approximately 2 mM. The suspensions of
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