The Ameliorative Effect of Naringenin on Paraquat-Induced Toxicity in Mitochondria Isolated from Rats

Abstract

Background: Paraquat (PQ) is a dipyridyl herbicide that sustains damage due to redox cycling. An important aspect of PQ toxicity is defined by its interactions with mitochondria. Objectives: This study was designed to evaluate the ability of naringenin (NG) to prevent PQ-induced mitochondrial dysfunction in rat-isolated liver mitochondria. Materials and Methods:To determine the IC50 of PQ , the mitochondrial viability was specified using an MTT assay. Different concentrations of PQ (0, 2.5, 5, and 10 mM) were used, and the IC50 of PQ was assigned as approximately 2 mM. The suspensions of

Cellular and Animal Models of Parkinson’s Disease: Rationale into Neuroprotective Effects of Naringenin

“…NAR protected against MPTP-induced neuroinflammation and resulted in oxidative stress in SH-SY5Y cells (Mani, Sekar, et al, 2018). It ameliorated the toxicity effect in mitochondria isolated from rats in the paraquat-induced model of PD (Daneshgar, Rezaei, et al, 2016). NAR exhibited anti-inflammatory effects via a mechanism associated with the Nrf2/HO-1 axis in the paraquat-induced cellular model of PD (SH-SY5Y cells).…”