Protective effect of N-Acetylcysteine against ethanol-induced gastric ulcer: a pharmacological assessment in mice

Abstract

Aim:Since there is an increasing need for gastric ulcer therapies with optimum benefit-risk profile. This study was conducted to investigate gastro-protective effects of N-acetylcysteine (NAC) against ethanol-induced gastric ulcer models in mice.Materials and Methods:A total of 41 mice were allocated into six groups consisted of 7 mice each. Groups 1 (normal control) and 2 (ulcer control) received distilled water at a dose of 10 ml/kg, groups 3, 4 and 5 were given NAC at doses 100, 300 and 500 mg/kg, respectively, and the 6th group received ranitidine (50 mg/kg). All drugs administered orally once daily for 7 days, on the 8th day absolute ethanol (7 ml/kg) was administrated orally to all mice to induce the acute ulcer except normal control group. Then 3 h after, all animals were sacrificed then consequently the stomachs were excised for examination.Results:NAC administration at the tested doses showed a dose-related potent gastro-protective effect with significant increase in curative ratio, PH of gastric juice and mucus content viscosity seen with the highest dose of NAC and it is comparable with that observed in ranitidine group.Conclusion:The present findings demonstrate that, oral NAC shows significant gastro-protective effects comparable to ranitidine confirmed by anti-secretory, cytoprotective, histological and biochemical data, but the molecular mechanisms behind such protection are complex.

Anti-ulcerogenic effect of KFP-H008 against ethanol-induced gastric ulcerviap38 MAPK/NF-κB pathway

“…17,18 In mice, ethanol consumption can produce oxidative stress and acute inammatory reaction. 19 However, oral administration of KFP-H008 effectively reversed ethanolinduced gastric injury in a dose-dependent manner, particularly at the dose of 8 mg kg À1 , the % inhibition was up to 72.81% (Fig. 1).…”

The Effect of N-Acetylcysteine on Respiratory Enzymes, ADP/ATP Ratio, Glutathione Metabolism, and Nitrosative Stress in the Salivary Gland Mitochondria of Insulin Resistant Rats

“…Group II-(C + NAC) rats receiving standard type LSM feed as well as N-acetylcysteine solution at a dose of 500 mg/kg body weight intragastrically (once a day, every day for eight weeks) at a volume of 2 mL/kg body weight (NAC, Sigma A9165) [26];…”

Efficacy of N-acetyl cysteine in dyspeptic patients with negative Helicobacter pylori infection

“…In fact, NAC has gastroprotective and anti-inflammatory effects and these gastroprotective effects are due to the NAC's antioxidant properties (20). It has also been stated that the gastroprotective effects of NAC are also due to its anti-secretory effects (21). In another study, Soliman et al (22) concluded that NAC's gastroprotective role is due the anti-oxidative, anti-apoptotic and anti-inflammatory mechanisms.…”