Protective effect of<i>Euterpe oleracea</i> Mart (açaí) extract on programmed changes in the adult rat offspring caused by maternal protein restriction during pregnancy

de, Graziele Freitas; Costa, Cristiane Aguiar da; Oliveira, Paola Raquel Braz de; Cordeiro, Viviane Silva Cristino; Santos, Izabelle Barcellos; Carvalho, Lenize Costa Reis Marins de; Souza, Maria das Graças Coelho de; Ognibene, Dayane Teixeira; Daleprane, Julio Beltrame; Sousa, Pergentino José C.; Resende, Ângela Castro; Moura, Roberto Soares de

doi:10.1111/jphp.12258

Cited by 45 publications

(25 citation statements)

References 40 publications

(51 reference statements)

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“…In accordance with our results, de Bem et al demonstrated that oral administration of Açai seed extract decreased renal structural changes in adult offspring rats (whose mothers were fed a low-protein (LP) diet during pregnancy) probably through vasodilatation and antioxidant effect. 38 Da costa et al reported that oral administration of Açai stone extract to rats leads to significant amelioration of renal histopathological changes in hypertensive rats. Those changes were in the form of decreased endothelial dysfunction and renal vascular structural changes.…”

Section: Discussionmentioning

confidence: 99%

Açai berry extract attenuates glycerol-induced acute renal failure in rats

Unis

2014

Renal Failure

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Acute renal failure (ARF) is one of the most common problems encountered in hospitalized critically ill patients. In recent years great effort has been focused on the introduction of herbal medicine as a novel therapeutic agent for prevention of ARF. Hence, the current study was designed to investigate the effect of Açai berry extract (ABE) on glycerol-induced ARF in rats.Results of the present study showed that rat groups that received oral ABE in a dose of 100 and 200 mg/kg/day for 7 days before or 7 days after induction of ARF by a single intramuscular glycerol injection reported a significant improvement in kidney functions tests [decrease in serum urea, serum creatinine, and blood urea nitrogen (BUN)] when compared to the ARF model groups. Moreover, there was significant amelioration in renal oxidative stress markers [renal catalase (CAT), renal reduced glutathione (GSH)] and renal histopathological changes in the ABE-treated groups when compared to ARF model groups. The most significant improvement was reported in the groups where ABE was administered in a dose 200 mg/kg/ day. These results indicate that ABE has a potential role in ameliorating renal damage involved in ARF.

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Section: Discussionmentioning

confidence: 99%

Açai berry extract attenuates glycerol-induced acute renal failure in rats

Unis

2014

Renal Failure

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“…Among these foods, there is the grape and its derivatives, which are among the largest sources of phenolic compounds [2] [21]. Along with this there is increasing evidence that the maternal diet composition is important in fetal growth and development, including specific aspects of reproduction and pregnancy outcomes, both in animals and humans [22] [23]. Consumption of foods rich in polyphenols contributing to human health is well established in the literature, however there is still no consensus among the researchers about the transgenerational effect.…”

Section: Discussionmentioning

confidence: 99%

Purple Grape Juice, an Important Flavonoids Source, Influence in Biochemical Parameters in Offspring of Wistar Rats

Hilger¹,

Wohlenberg²,

Schaffer³

et al. 2015

FNS

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Our objective was to evaluate the effect of chronic gestational treatment and post-breast feeding with purple grape juice on the biochemical parameters in offspring of dams. We used 40 male offspring from 14 Wistar rats which received purple grape juice or water by gavage daily for 42 days at a dose of 7 microliters/g. The offspring were divided into groups of water or juice. All received daily purple grape juice or water by gavage for 30 days after completion of their nursing period at a dose of 7 microliters/g. At the end of the treatment period, the offspring were euthanized by decapitation with its truncal blood collected and subsequently separated the serum from the blood. The measurements were performed by automation or by manual dosing. Considering the gestational factor, grape juice was able to reduce levels of total cholesterol, triglycerides, urea, alanine aminotransferase (ALT), and not alter the levels of creatinine and aspartate aminotransferase (AST) in serum of the offspring. When considering the post-breast feeding factor, grape juice resulted in an improvement in HDL-C. We concluded that purple grape juice was able to produce a beneficial effect on certain biochemical parameters in offspring.

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“…In contrast, maternal intake of polyphenol-rich foods can protect the offspring against the development of chronic diseases later in life through mechanism that is related to inflammation or oxidative stress (de Bem et al, 2014;Mukai, Sun, & Sato, 2013;Vanhees et al, 2013).…”

Section: Introductionmentioning

confidence: 91%

Polyphenols-rich fruit in maternal diet modulates inflammatory markers and the gut microbiota and improves colonic expression of ZO-1 in offspring

Morais

Oyama

Conrado

et al. 2015

Food Research International

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Protective effect ofEuterpe oleracea Mart (açaí) extract on programmed changes in the adult rat offspring caused by maternal protein restriction during pregnancy

Abstract: Treatment of protein-restricted dams with ASE provides protection from later-life hypertension, oxidative stress, renal functional and structural changes, probably through a vasodilator and antioxidant activity.

Cited by 45 publications

References 40 publications

Açai berry extract attenuates glycerol-induced acute renal failure in rats

Açai berry extract attenuates glycerol-induced acute renal failure in rats

Purple Grape Juice, an Important Flavonoids Source, Influence in Biochemical Parameters in Offspring of Wistar Rats

Polyphenols-rich fruit in maternal diet modulates inflammatory markers and the gut microbiota and improves colonic expression of ZO-1 in offspring

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