Purple Grape Juice, an Important Flavonoids Source, Influence in Biochemical Parameters in Offspring of Wistar Rats

Abstract

Our objective was to evaluate the effect of chronic gestational treatment and post-breast feeding with purple grape juice on the biochemical parameters in offspring of dams. We used 40 male offspring from 14 Wistar rats which received purple grape juice or water by gavage daily for 42 days at a dose of 7 microliters/g. The offspring were divided into groups of water or juice. All received daily purple grape juice or water by gavage for 30 days after completion of their nursing period at a dose of 7 microliters/g. At the end of the treatment period, the offspring were euthanized by decapitation with its truncal blood collected and subsequently separated the serum from the blood. The measurements were performed by automation or by manual dosing. Considering the gestational factor, grape juice was able to reduce levels of total cholesterol, triglycerides, urea, alanine aminotransferase (ALT), and not alter the levels of creatinine and aspartate aminotransferase (AST) in serum of the offspring. When considering the post-breast feeding factor, grape juice resulted in an improvement in HDL-C. We concluded that purple grape juice was able to produce a beneficial effect on certain biochemical parameters in offspring.

Purple grape juice consumption during the gestation reduces acetylcholinesterase activity and oxidative stress levels provoked by high-fat diet in hippocampus from adult female rats descendants

“…Previous studies of our group have already demonstrated the benefits of grape juice consumption in a transgenerational model on biochemical parameters (Hilger et al 2015). The results showed that the grape juice consumption generated benefits since purple grape juice decreased AChE enzyme activity in the hippocampus about control groups in both diets, proving their protective effect on brain tissue.…”

“…It is known that grape juice is a food rich in phenolic compounds, and therefore its consumption as a nutritional source may be recommended (Dani et al 2007). The ingestion of grape juice has gained prominence in in vivo research for its antioxidant and antiinfl ammatory power, acting in favor of health (Buchner et al 2014, Hilger et al 2015. Recent studies with rats by our research group have demonstrated the grape juice consumption during the pregnancy can promote benefits to the pregnancy and her offsprings, strengthening the hypothesis that this food is a great ally for the mother' health and her offspring (Gonçalves et al 2017, Wohlenberg et al 2015.…”

Gestational purple grape juice consumption does not change fetal ductus arteriosus constriction in Wistar rats

“…Maternal intake of polyphenol‐rich foods during the third gestational trimester is related to DA constriction (Vian et al, 2018; Zielinsky et al, 2012; Zielinsky Jr., Piccoli Jr., Manica, & Nicoloso, 2010), so it could be useful to avoid intake of these foods during this period. On the other hand, foods rich in phenolic compounds have a number of health benefits at different stages of life (Gutierrez, Bowden, & Willoughby, 2016) and can influence the health of both the mother and offspring (Gonçalves et al, 2017; Gonçalves et al, 2018; Hilger et al, 2015). Grapes are phenolic‐rich fruits containing high amounts of resveratrol (Dani et al, 2007), and can modulate oxidative stress parameters, alongside their hepatoprotective effects (Buchner et al, 2014; dos Santos Lacerda et al, 2018).…”

Naringin Supplementation during Pregnancy Induces Sex and Region-Specific Alterations in the Offspring’s Brain Redox Status

“…In this context, the Developmental Origins of Health and Disease (DOHaD) field of study aims to understand how interventions during critical periods of development, such as pregnancy, might induce alterations in the progeny’s development [ 20 ]. In recent years, an increasing body of evidence from animal studies has been demonstrating that maternal diet interventions during pregnancy, such as polyphenol supplementation, can induce postnatal alterations in the offspring’s blood biochemical parameters, antioxidant status, inflammatory status, and cholesterol transport in different tissues [ 21 , 22 , 23 , 24 , 25 ]. Additionally, epigallocatechin gallate, a flavonoid commonly found in green tea, was able to inhibit migration and adhesion of neural progenitor cells in vitro, thereby suggesting that polyphenols might also interfere during neurodevelopment [ 26 ].…”