Protective effect of gallic acid on alloxan-induced oxidative stress and osmotic fragility in rats

Abstract

<jats:p> In the present study, we investigated the antioxidant effect of gallic acid (GA) on membrane lipid peroxidation and osmotic fragility in alloxan-induced diabetic Wistar rats. GA was administered orally at doses of 5, 10, and 20 mg/kg body weight for 45 days, after which liver and kidney tissues were analyzed for the degree of lipid peroxidation, reduced glutathione, and the activities of antioxidants such as catalase, superoxide dismutase, and glutathione peroxidase. Administration of GA to alloxan-induced diabetic rats reduced the blood glucose level with an increase in the level of insulin. Liver and kidney tissues from diabetic animals exhibited disturbances in antioxidant defense compared with normal rats. GA at a dose of 20 mg/kg b.w. showed a significant effect than that of the other doses. In addition, the results revealed that GA protected the integrity of erythrocyte membrane in diabetic rats as demonstrated by lower percentage of hemolysis and resistance to hydrogen peroxide-induced peroxidation. The anti-hyperglycemic activity of GA in alloxan-induced diabetic rats was also comparable with glibenclamide, a reference drug. These results suggest that GA could provide a beneficial effect on diabetes by decreasing oxidative stress-related diabetic complications. </jats:p>

Rutin potentiates insulin receptor kinase to enhance insulin-dependent glucose transporter 4 translocation

“…We identified gallic acid, quercitrin, and rutin as abundant polyphenols in the extract of TS. Recent reports have indicated that gallic acid can increase GLUT4 translocation via the Akt‐insulin‐independent pathway, up‐regulation of PPAR‐γ expression , and decreasing the oxidative stress‐related diabetic complications . Most previous studies on the normoglycemic effects of other natural compounds are primarily focused on the antioxidant effect , GLUT4 translocation , glucose uptake , Akt , and AMPK regulation to enhance insulin sensitivity.…”

“…Recent reports have indicated that gallic acid can increase GLUT4 translocation via the Akt-insulin-independent pathway, up-regulation of PPAR-␥ expression [24,26], and decreasing the oxidative stress-related diabetic complications [33]. Most previous studies on the normoglycemic effects of other natural compounds are primarily focused on the antioxidant effect [33], GLUT4 translocation [36,37], glucose uptake [24,38], Akt [37][38][39], and AMPK [40,41] regulation to enhance insulin sensitivity. Rutin, a well-known flavonoid in many food plants, enhances Akt phosphorylation and improves insulin resistance [14,15].…”

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

“…In contrast, plant-derived antidiabetic agents can alleviate diabetic complications through glycaemic control, antioxidant mechanism, and inhibition of pathological signal transductions involved in inflammation, fibrosis, and apoptosis ( Figure 2). Curcumin [73], resveratrol [74], naringenin [34], quercetin [75], apigenin [76,77], myricitrin [78,79], baicalin [80,81], luteolin [82,83], mangiferin [59,84,85], emodin [86,87], rosmarinic acid [88], berberine [89], stevioside [90,91], asiatic acid [92][93][94], glycyrrhizin [95][96][97][98], baicalin [99,100], silymarin [101], gallic acid [102][103][104], catechins [105,106], thymoquinone [107], and ferulic acid [108][109][110] have been revealed to attenuate diabetic vascular complications via modulating multiple molecular targets.…”

Equilíbrio acidobásico, parâmetros urinários e sanguíneos de gatos induzidos ao estresse e suplementados com composto antioxidante

“…2) O aumento da FOE pode ocorrer em situações de estresse devido ao aumento da peroxidação lipídica, a qual atrapalha a organização dos fosfolipídeos (fosfatidilserina e da fostadiletanolamina) da membrana plasmática (Jain, 1984) e, consequentemente, reduz a fluidez celular (Hebbel, 1986). Sabe-se que o antioxidante ácido gálico protegeu a integridade da membrana dos eritrócitos de ratos diabéticos, apresentando menor porcentagem de hemólise (Ramkumar et al, 2014). Há relato de que a suplementação com vitamina E, outro potente antioxidante, reduziu a FOE em ratos induzidos ao estresse oxidativo (Ambali et al, 2010).…”