Protective effect of ellagic acid on healing alveolar bone after tooth extraction in rat—A histological and immunohistochemical study

Al-Obaidi, Mazen M. Jamil; Al-Bayaty, Fouad Hussain M.H; Batran, Rami Al; Hassandarvish, Pouya; Rouhollahi, Elham

doi:10.1016/j.archoralbio.2014.06.001

Cited by 32 publications

(35 citation statements)

References 63 publications

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“…17 Besides, it has been reported that EA can be used to prevent alveolar bone loss and accelerate the formation of new bone aer teeth are extracted. 18 In this study, novel thermosensitive hydrogels based on chitosan (CS) and silk sericin (SS) and loaded with longan seed extract (LE) as a model drug were developed to achieve a balance between the thermogelling property and biocompatibility for use in bone tissue engineering. It was hypothesized that a system based on a combination of CS and SS could form a sol at room temperature and be transformed rapidly into a gel state at physiological temperature.…”

Section: Introductionmentioning

confidence: 99%

The potential use of thermosensitive chitosan/silk sericin hydrogels loaded with longan seed extract for bone tissue engineering

Pankongadisak

Suwantong

2018

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

The potential use of thermosensitive chitosan/silk sericin hydrogels loaded with longan seed extract for bone tissue engineering

Pankongadisak

Suwantong

2018

RSC Adv.

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“…Wnt/β-catenin from PG is an active component that acts to increase the signal for osteogenesis increased. Specifically, ellagic acid can increase osteopontin and osteocalcin [25]. PG seed oil extract was reported to play a role as a bone biomarker, specifically to detect osteocalcin [26].…”

Section: Resultsmentioning

confidence: 99%

Analysis Reactivity of Punica Granatum Polyphenols to the Osteocalcin, Bone Morphogenetic Protein-2, and Collagen Type-1

Burhan

Thahar

Abidin

et al. 2018

Asian J Pharm Clin Res

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Objective: Punica granatum (PG) contains anthocyanins which are useful as antioxidants, anti-inflammatory, and prevent cancer, while also increasing bone cell proliferation and osteoblasts differentiation in bone remodeling.Methods: The reactivity of osteocalcin protein markers with PG polyphenol fractionation hydrogels observed using enzyme-linked immunosorbent assay, the degree of reactivity was determined by optical density at 550 nm.Results: PG butanol fraction has better reactivity compared to the total extract, ethyl, and hexane fraction. Based on the reactivity distribution, bone morphogenetic protein (BMP)-2 and collagen Type-1 had a dominant distribution compared to osteocalcin, but the theses proteins had a strong relation (r = 0.8) with probability (P < 0.05).Conclusion: PG butanol fraction had better reactivity to osteocalcin, BMP-2, and collagen Type-1 compared with total extract, hexane, and ethyl fraction. The four PG polyphenol fractionations have dominant reactivity to BMP-2.

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“…27 Formation of new woven bone was initiated on the seventh day and became visible along the lateral alveolar wall and the base of the socket. 28,29 Woven bone formation increased during the second week of the socket healing process. The newly formed woven bone was surrounded by numerous newly differentiated osteoblasts.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Anadara granosa shell-Stichopus hermanni granules at accelerating woven bone formation fourteen days after tooth extraction

Sari¹,

Kurniawan²

2019

Dent. J.

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Background: Post-extraction complications can cause alveolar bone resorption. Hydroxyapatite-tricalcium phosphate (HA-TCP) is one potential bone graft material that can be synthesized from Anadara granosa shell. Another biomarine, Stichopus hermanni, contains hyaluronic acid which can accelerate bone formation on the fourteenth day. Purpose: This study aims to prove the effectiveness of Anadara granosa shell-Stichopus hermanni granules in weaving bone formation fourteen days after tooth extraction. Methods: Twenty-five male Wistar rats were divided into five groups. Their lower left incisor was extracted with gelatin being administered to the control group (C) and granule scaffold derived from Anadara granosa (AG) shell and Anadara granosa shell-Stichopus hermanni at concentrations of 0.4%-0.8%-1.6% (AGSH1-AGSH2-AGSH3) to the treatment group. This study developed a HA-TCP synthesized from Anadara granosa combined with whole Stichopus hermanni to create granule scaffolds by means of a freeze-dried method. The jaw was removed on the fourteenth day post-tooth extraction. Observation of HPA involved the use of an Image Raster®. The resulting data was subjected to analysis by ANOVA and tukey-HSD tests (p<0.05). Results: Data showed the mean of C=0.157±0.078; AG=1.139±0.371; AGSH1=1.595±0.291; AGSH2=1.740±0.308; and AGSH3=1.638±0.286. Statistical analyses showed significant differences in the woven bone area (mm2) between C and the treatment groups AG;AGSH1;AGSH2; AGSH3; and between AG and the AGSH2 groups. Conclusions: Scaffold granules from Anadara granosa shells and Stichopus hermanni effectively accelerate the bone formation process with the most effective being Stichopus hermanni at a concentration of 0.8%.

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Protective effect of ellagic acid on healing alveolar bone after tooth extraction in rat—A histological and immunohistochemical study

Cited by 32 publications

References 63 publications

The potential use of thermosensitive chitosan/silk sericin hydrogels loaded with longan seed extract for bone tissue engineering

The potential use of thermosensitive chitosan/silk sericin hydrogels loaded with longan seed extract for bone tissue engineering

Analysis Reactivity of Punica Granatum Polyphenols to the Osteocalcin, Bone Morphogenetic Protein-2, and Collagen Type-1

Effectiveness of Anadara granosa shell-Stichopus hermanni granules at accelerating woven bone formation fourteen days after tooth extraction

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