Protective Effect of Curcumin on Acrylamide-Induced Hepatic and Renal Impairment in Rats: Involvement of CYP2E1

Rui, Sun; Chen, Wenhui; Cao, Xiaolu; Guo, Jie; Wang, Jun

doi:10.1177/1934578x20910548

Cited by 13 publications

(18 citation statements)

References 42 publications

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“…In recent years, evidence on its hepatotoxicity has been reported, for the liver is the main site of AA biotransformation. Sun et al reported that when rats were intraperitoneally injected with 40 mg/kg AA for four weeks, the levels of serum ALT and AST were markedly higher in the treated group than in the normal control group [ 38 ]. Additionally, AA (20 mg/kg) increased the levels of liver oxidative stress markers, including protein carbonyl content, nitric oxide, and lipid peroxides, but markedly decreased the activity of liver antioxidants, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px).…”

Section: Discussionmentioning

confidence: 99%

Associations of acrylamide with non-alcoholic fatty liver disease in American adults: a nationwide cross-sectional study

et al. 2021

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Background Acrylamide (AA) is a toxicant to humans, but the association between AA exposure and the risk of non-alcoholic fatty liver disease (NAFLD) remains unclear. In this study, our objective is to examine the cross-sectional association between AA exposure and the risk of NAFLD in American adults. Methods A total of 3234 individuals who took part in the National Health and Nutrition Examination Survey (NHANES) 2003–2006 and 2013–2016 were enrolled in the study. NAFLD was diagnosed by the U.S. Fatty Liver Index. Multivariable logistic regression models were applied to estimate the association between AA and NAFLD in the whole group and the non-smoking group. Results We discovered that in the whole group, serum hemoglobin adducts of AA (HbAA) were negatively associated with the prevalence of NAFLD after adjustment for various covariables (P for trend < 0.001). Compared with individuals in the lowest HbAA quartiles, the odds ratios (ORs) with 95% confidence intervals (CIs) in the highest HbAA quartiles were 0.61 (0.46–0.81) and 0.57 (0.36–0.88) in the whole group and the non-smoking group, respectively. In contrast, HbGA/HbAA showed a significantly positive correlation with the prevalence of NAFLD in both groups (P for trend < 0.001). In addition, HbGA was not significantly associated with NAFLD in the whole group or the non-smoking group. Conclusions HbAA is negatively associated with NAFLD whereas HbGA/HbAA is positively associated with NAFLD in adults in the U.S. Further studies are needed to clarify these relationships.

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Section: Discussionmentioning

confidence: 99%

Associations of acrylamide with non-alcoholic fatty liver disease in American adults: a nationwide cross-sectional study

et al. 2021

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“…Hepatotoxic group (Group II): Rats received oral administration of acrylamide at a dose of 50 mg/kg body weight for four weeks [7] .…”

Section: Animals and Experimental Designmentioning

confidence: 99%

“…Acrylamide [50 mg/kg/day] was dissolved in 10 ml distilled water, so each 1 ml distilled water contained 5 ml acrylamide. Each rat was given distilled water containing acrylamide by weight and orally administered to rats for four weeks via gastric intubation [7] .…”

Section: Hepatotoxic Plus Ginger Group (Group Iv)mentioning

confidence: 99%

Protective Effect of Cinnamon and Ginger on Acrylamide Induced Hepatotoxicity in Adult Male Albino Rats

Gawesh

Elshoura

Abbas

2021

International Journal of Medical Arts

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Background: Background: Acrylamide [ACR] is an essential chemical that is extensively used in many industries and also in laboratories such as treatment of drinking water, wastewater, and soil, production of paper, petroleum, mine, asphalt, dyes, adhesives, and polishes; it is known as a possible carcinogenic compound. Ginger oleoresin's hepatoprotective role can be attributed to its free radical scavenging, anti-inflammatory, and hypolipidemic activities and is partially mediated by the 6-gingerol, shogaol, and zingerone of its active component. Cinnamomum zeylanicum is used to treat many diseases and to prevent such diseases. Aim of the work:Evaluation of the effects of cinnamon and ginger extracts administration on Hepatotoxicity adult male albino rats. Materials and Methods:The groups were divided into five adult male albino rats of a local strain: Group I: acted as a control group with regular salines, group II: hepatotoxicity caused by acrylamid, groups III: hepatotoxicity plus cinnamon, group IV: hepatotoxicity plus ginger, group V: hepatotoxicity plus cinnamon and ginger. Samples for alanine aminotransferase [ALT], aspartate transfers of amino [AST], urea, creatinine, blood urea nitrogen (BUN), total cholesterol, triglyceride [TG], malondialdehyde, tumor necrosis factor α [TNF], superoxide dismutase [SOD], glutathione peroxidase [GPX], as well as total antioxidant [TAC] levels were obtained at the end of the experimental period.Results: Administration of cinnamon and ginger to hepatotoxic rats led to a significant decrease in the mean value of ALT, AST, urea, creatinine, BUN, MDA, and TNF. In addition, it is associated with a significant increase of SOD, GPX, and TAC. Conclusion:Cinnamon and ginger have a protective effect against abnormalities in hepatotoxic rats due to its several protective properties.

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“…Moreover, acrylamide is now classified by the International Agency for Research on Cancer as a probable human carcinogen 3 . As a small unsaturated amide, AC is absorbed readily by humans and animals after ingestion and distributed into several vital organs such as the thymus, heart, brain, liver, and kidney, where it may induce toxicity or carcinogenicity 4 .…”

Section: Introductionmentioning

confidence: 99%

Nanocurcumin and curcumin prevent N, N'-methylenebisacrylamide-induced liver damage and promotion of hepatic cancer cell growth

Atia

Abdel-Tawab

Mostafa

et al. 2022

Sci Rep

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Acrylamide (AC) is an environmental contaminant with cancer-promoting and cytotoxic properties, while curcumin (Cur.) is a phytochemical with documented anticancer and cytoprotective efficacy. Nanoparticle formulations can increase the efficacy of phytochemicals, so we examined the anticancer and hepatoprotective efficacies of nanocurcumin (N.Cur). Curcumin and nanocurcumin reduced HepG2 and Huh-7 cancer cell viability and increased apoptosis in the presence and absence of AC, while AC alone promoted proliferation. Furthermore, the anticancer efficacy of nanocurcumin was greater than that of curcumin. In mice, AC greatly increased hepatic expression of CYP2E1, P53, cleaved caspase-3, and COL1A1 as well as serum alanine aminotransferase and aspartate aminotransferase activities. These effects were reversed by nanocurcumin and curcumin. Nanocurcumin also reduced the histopathology and fibrosis caused by AC, and reversed AC-induced glycogen depletion. Nanoparticle formulation can increase the anticancer and hepatoprotective efficiencies of curcumin.

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Protective Effect of Curcumin on Acrylamide-Induced Hepatic and Renal Impairment in Rats: Involvement of CYP2E1

Cited by 13 publications

References 42 publications

Associations of acrylamide with non-alcoholic fatty liver disease in American adults: a nationwide cross-sectional study

Associations of acrylamide with non-alcoholic fatty liver disease in American adults: a nationwide cross-sectional study

Protective Effect of Cinnamon and Ginger on Acrylamide Induced Hepatotoxicity in Adult Male Albino Rats

Nanocurcumin and curcumin prevent N, N'-methylenebisacrylamide-induced liver damage and promotion of hepatic cancer cell growth

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