Protective Effect of Cinnamon and Ginger on Acrylamide Induced Hepatotoxicity in Adult Male Albino Rats

Abstract

Background: Background: Acrylamide [ACR] is an essential chemical that is extensively used in many industries and also in laboratories such as treatment of drinking water, wastewater, and soil, production of paper, petroleum, mine, asphalt, dyes, adhesives, and polishes; it is known as a possible carcinogenic compound. Ginger oleoresin's hepatoprotective role can be attributed to its free radical scavenging, anti-inflammatory, and hypolipidemic activities and is partially mediated by the 6-gingerol, shogaol, and zingerone of its active component. Cinnamomum zeylanicum is used to treat many diseases and to prevent such diseases. Aim of the work:Evaluation of the effects of cinnamon and ginger extracts administration on Hepatotoxicity adult male albino rats. Materials and Methods:The groups were divided into five adult male albino rats of a local strain: Group I: acted as a control group with regular salines, group II: hepatotoxicity caused by acrylamid, groups III: hepatotoxicity plus cinnamon, group IV: hepatotoxicity plus ginger, group V: hepatotoxicity plus cinnamon and ginger. Samples for alanine aminotransferase [ALT], aspartate transfers of amino [AST], urea, creatinine, blood urea nitrogen (BUN), total cholesterol, triglyceride [TG], malondialdehyde, tumor necrosis factor α [TNF], superoxide dismutase [SOD], glutathione peroxidase [GPX], as well as total antioxidant [TAC] levels were obtained at the end of the experimental period.Results: Administration of cinnamon and ginger to hepatotoxic rats led to a significant decrease in the mean value of ALT, AST, urea, creatinine, BUN, MDA, and TNF. In addition, it is associated with a significant increase of SOD, GPX, and TAC. Conclusion:Cinnamon and ginger have a protective effect against abnormalities in hepatotoxic rats due to its several protective properties.

Extraction of Active Compounds from Mixtures of Hemp (Cannabis sativa) with Plants of the Zingiberaceae Family

“…The cardamom total phenolics, which were the lowest among the materials measured, aligns well with results that Oueslati et al obtained from ethanolic extracts, 51.7 mg GA/g extract [23], and are even higher than results from ethanolic extracts that Tarfaoui et al obtained, 33.45 (±0.35) mg GA/g extract [12]. Furthermore, the values for ginger and turmeric, with the highest TPC difference between materials, are similar to those reported by Sepahpour et al for turmeric ethanolic extracts, 172.1 (±1.4) mg GA/g extract [24], and by El-Sayed for ginger methanolic extract, 266.7 mg GA/g extract [25].…”

Impact of Betanin on Diabetes Induced Experimentally by Streptozotocin and Associated Histopathological Changes in Albino Adult Rats

“…Blood was centrifuged at 5000 revolutions per minute for 10 minutes to extract serum after being allowed to clot. alanine amino transferase, Aspartate amino transferase, high density lipoprotein, triglyceride, total cholesterol, low density lipoprotein, serum insulin level (9), , malondialdehyde (11), catalase (12), tumor necrosis factor alpha (11), lactate dehydrogenase (12), nuclear factor kappa (11) and interleukin 1 and interleukin 6 (12).…”