Associations of acrylamide with non-alcoholic fatty liver disease in American adults: a nationwide cross-sectional study

Liu, Zhening; Wang, Jinghua; Chen, Shenghui; Xu, Chengfu

doi:10.1186/s12940-021-00783-2

Cited by 9 publications

(4 citation statements)

References 64 publications

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“…Previous studies revealed that serum and hepatic advanced glycation end-products were significantly elevated in non-alcoholic steatohepatitis patients (44) , and the circulating level of advanced glycation end-products was associated with IR even in non-obese, non-diabetic subjects (45) . In addition, acrylamide (one of the Maillard reaction products) was also associated with NAFLD in the NHANES (46) . Another interpretation concerns the wide range of food additives in UPF.…”

Section: Discussionmentioning

confidence: 99%

Association between ultra-processed foods consumption and risk of non-alcoholic fatty liver disease: a population-based analysis of NHANES 2011–2018

et al. 2022

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An increasing number of studies have evaluated the association between ultra-processed foods (UPF) consumption and metabolic disorders. However, the association between UPF intake and non-alcoholic fatty liver disease (NAFLD) remains unclear. In this study, we analyzed data from 6545 participants who were recruited in National Health and Nutrition Examination Surveys (NHANES) 2011–2018. UPF were defined in light of the NOVA food classification system and divided into quartiles based on its proportion of total weight intake. Complex logistic regression models were used to assess the association between UPF and NAFLD. Mediation analyses were conducted to reveal underlying mediators. We found that NAFLD patients consumed more UPF than controls (925.92 ± 18.08 versus 812.70 ± 14.32 grams/day, P <0.001). Dietary intake of UPF (% weight) was negatively related to the Healthy Eating Index-2015 (HEI-2015) score (Spearman r = -0.32, P<0.001). In the multivariable model, the highest quartile compared with the lowest, the ORs (95% CIs) were 1.83 (1.33–2.53) for NAFLD (OR per 10% increment: 1.15; 95% CI: 1.09–1.22; P for trend <0.001) and 1.52 (1.12–2.07) for insulin resistance (OR per 10% increment: 1.11; 95% CI: 1.05–1.18; P for trend =0.002). Mediation analyses revealed that poor diet quality, high saturated fat and refined grain intake partly mediated the association between UPF and NAFLD. In conclusion, high UPF intake was associated with an increased risk of NAFLD in US adults. Further prospective studies are needed to verify these findings.

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Section: Discussionmentioning

confidence: 99%

Association between ultra-processed foods consumption and risk of non-alcoholic fatty liver disease: a population-based analysis of NHANES 2011–2018

et al. 2022

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“…More recently, results of subsequent surveys have continued to demonstrate that Hb adducts of GA are measurable in the US population. For example, Liu et al (2021) reported Hb-GA/Hb-AA ratios in the region of 0.7-1.1 in 3,234 participants of the 2003-2006 and 2013-2016 surveys. Similarly, in Europe, Hb adducts of both AA and GA have been measured in the European Prospective Investigation into Cancer and Nutrition (EPIC). For example, median Hb-GA/Hb-AA ratios of 0.7-1.0 were reported in a subgroup of 801 non-smoking postmenopausal women from 8 European countries (Obon-Santacana et al, 2017).…”

Section: Measurement Of Haemoglobin Adductsmentioning

confidence: 99%

Assessment of the genotoxicity of acrylamide

Benford¹,

Bignami²,

Chipman³

et al. 2022

EFS2

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EFSA was requested to deliver a statement on a recent publication revisiting the evidence for genotoxicity of acrylamide (AA). The statement was prepared by a Working Group and was endorsed by the CONTAM Panel before its final approval. In interpreting the Terms of Reference, the statement considered the modes of action underlying the carcinogenicity of AA including genotoxic and non‐genotoxic effects. Relevant publications since the 2015 CONTAM Panel Opinion on AA in food were reviewed. Several new studies reported positive results on the clastogenic and mutagenic properties of AA and its active metabolite glycidamide (GA). DNA adducts of GA were induced by AA exposure in experimental animals and have also been observed in humans. In addition to the genotoxicity of AA, there is evidence for both secondary DNA oxidation via generation of reactive oxygen species and for non‐genotoxic effects which may contribute to carcinogenesis by AA. These studies extend the information assessed by the CONTAM Panel in its 2015 Opinion, and support its conclusions. That Opinion applied the margin of exposure (MOE) approach, as recommended in the EFSA Guidance for substances that are both genotoxic and carcinogenic, for risk characterisation of the neoplastic effects of AA. Based on the new data evaluated, the MOE approach is still considered appropriate, and an update of the 2015 Opinion is not required at the present time.

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“…9,10 Epidemiological evidence revealed that the ratio of HbGA to HbAA (HbGA/HbAA) was positively associated with triglyceride, obesity, and nonalcoholic fatty liver disease in American adults. 10,23,24 Previous studies reported that HbAA was inversely associated with the serum insulin. 25 Similarly, a recent study from NHANES found an inverse relationship between HbAA and diabetes prevalence and demonstrated a higher prevalence of diabetes mellitus in relation to the HbGA/HbAA ratio.…”

Section: ■ Introductionmentioning

confidence: 99%

“…AA can directly be conjugated with glutathione and subsequently be epoxidated into glycidamide (GA) via the cytochrome P450 2E1 in vivo . AA and its primary metabolite GA could link with hemoglobin to generate the adduct of AA (HbAA) and adduct of GA (HbGA), which are used as long-term biomarkers of AA exposure. , Meanwhile, the ratio of HbGA to HbAA (HbGA/HbAA) considered as a potential biomarker of metabolic capacity of AA and the sum of HbAA and HbGA (HbAA + HbGA) were found to have complex links to diabetes and obesity. , Epidemiological evidence revealed that the ratio of HbGA to HbAA (HbGA/HbAA) was positively associated with triglyceride, obesity, and non-alcoholic fatty liver disease in American adults. ,, Previous studies reported that HbAA was inversely associated with the serum insulin . Similarly, a recent study from NHANES found an inverse relationship between HbAA and diabetes prevalence and demonstrated a higher prevalence of diabetes mellitus in relation to the HbGA/HbAA ratio .…”

Section: Introductionmentioning

confidence: 99%

Associations of Hemoglobin Adducts of Acrylamide and Glycidamide with Prevalent Metabolic Syndrome in a Nationwide Population-Based Study

Wan

Zhu

Zhuang

et al. 2022

J. Agric. Food Chem.

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Environmental and dietary exposures to acrylamide (AA) have been linked with various metabolic-related outcomes, but the results are mixed. However, the association between long-term exposure to AA and the prevalence of metabolic syndrome (MetS) remains unknown. In this study, we aimed to assess the relationship between hemoglobin adducts of AA, biomarkers of internal exposure to AA, and MetS prevalence among a U.S. nationwide population. MetS patients were defined by meeting three or more of the following five characteristics: elevated blood pressure, high fasting glucose, abdominal obesity, hypertriglyceridemia, and lower high-density lipoprotein cholesterol (HDL-C). Multivariate-adjusted logistic regression models and restricted cubic spline models were used to analyze the associations between AA hemoglobin biomarkers and MetS prevalence. A total of 1552 MetS cases were documented. After adjustment for the potential confounders, the odds ratios (95% confidence intervals) of MetS prevalence in the highest quartile of AA hemoglobin biomarkers were 0.60 (0.40–0.89), 1.26 (0.84–1.89), 0.93 (0.71–1.21), and 1.61 (1.18–2.20) for HbAA, HbGA, the sum of HbAA and HbGA (HbAA + HbGA), and the ratio of HbGA to HbAA (HbGA/HbAA), compared with the lowest quartile, respectively. HbAA was significantly and inversely associated with blood pressure, fasting glucose, abdominal obesity, hypertriglyceridemia, and low HDL-C, while the HbGA/HbAA ratio was also positively associated with abdominal obesity, hypertriglyceridemia, and low HDL-C. The restricted cubic spline models revealed a positive relationship between the HbGA/HbAA ratio and the prevalence of MetS, while the HbAA level was inversely associated with MetS prevalence. Our current findings provided epidemiological evidence that HbAA and the HbGA/HbAA ratio were significantly associated with MetS prevalence among general U.S. adults. Further studies should be conducted to examine the association between internal exposure to AA and MetS prevalence.

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Associations of acrylamide with non-alcoholic fatty liver disease in American adults: a nationwide cross-sectional study

Cited by 9 publications

References 64 publications

Association between ultra-processed foods consumption and risk of non-alcoholic fatty liver disease: a population-based analysis of NHANES 2011–2018

Association between ultra-processed foods consumption and risk of non-alcoholic fatty liver disease: a population-based analysis of NHANES 2011–2018

Assessment of the genotoxicity of acrylamide

Associations of Hemoglobin Adducts of Acrylamide and Glycidamide with Prevalent Metabolic Syndrome in a Nationwide Population-Based Study

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