Protective effect of Centella asiatica on antioxidant tissue defense system against adriamycin induced cardiomyopathy in rats

Botanical Pharmacognosy of Centella asiatica (Linn.)Urban

“…Data on many recent experimental studies have scientifically validated the traditional uses of the extract of Mandukaparni. These findings endorse that the plant having multiple therapeutic potentials, which were amply and vividly demonstrated by different animal models such as wound-healing model in rat, [10][11] streptozocin-induced Alzheimeir's model 12 , zebrafish Parkinson's model, 13 adriamycin-induced cardiomyopathy model, 14 nitroglycerine and bradykinin induced hyperalgesia (migraine) model, 15 radiationinduced dermatitis model, memory impairment induced by cerebral ischemia-reperfusion 16 and also having anxiolytic, 17 neuronal dendritic growth and nerve stimulating effects, 18 suppression of scars in diabetic patients, 19 and reverse mutation assay for non-toxicity, safety and nonmutagenicity of the extract, 20 protection of healthy cells against radiationinduced damages. 21 However, the botanical standards specified for evaluation of intact plant material of Centella asiatica in literature [22][23][24][25] seemed to be too scanty and not exhaustive enough to extricate the crude raw materials from the adulterants and substitutes.…”

Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats

“…The plant extract also showed central nervous system depressant activity and inhibition on biosynthetic activity of fibroblasts (Del Vecchio et al, 1984;Babu et al, 1995). In the recent reports, it has been proved that C. asiatica has anti-lipid peroxidative and free radical scavenging activities (Jayashree et al, 2003;Gnanapragasam et al, 2004). The major active constituents present in the extract of C. asiatica extract are triterpenes and polyphenols (Inamdar et al, 1996;Zainol et al, 2003).…”

Evaluation of Diuretic Activity of Aqueous Extract of Leaves of Centella Asiatica

“…[1,2,3] Centella asiatica L. has been used as a medicinal herb for thousands of years in India, China, Srilanka and Nepal for treating skin problems, to heal wounds, for revitalizing the nerves and brain cells, hence primarily known as a "Brain food" in India. [4,5,6] Centella asiatica (Linn.) Synonym Hydrocotyle asiatica Linn.…”