Protection of lead-induced cytotoxicity using paramagnetic nickel–insulin quantum clusters

Abstract

Receptor targeted ferromagnetic Insulin–Nickel Quantum fluorescence Clusters (INiQCs) can specifically detect Pb2+ and prevents Pb2+ poisoning.

Insulin–cobalt core–shell nanoparticles for receptor-targeted bioimaging and diabetic wound healing

“…67,70 C–N stretching was observed in insulin and ICoNPs at 1032.13 cm −1 . 31 Amide I, amide II, and amide III are found at 1631.19 cm −1 , 1529.41 cm −1 , and 1244.60 cm −1 , respectively, in insulin and ICoNPs. 31,32,34 C–H bond was observed in insulin and ICoNPs at 1390.70 cm −1 .…”

“…31 Amide I, amide II, and amide III are found at 1631.19 cm −1 , 1529.41 cm −1 , and 1244.60 cm −1 , respectively, in insulin and ICoNPs. 31,32,34 C–H bond was observed in insulin and ICoNPs at 1390.70 cm −1 . 31 Deformational scissor water vibrations were observed at 1573.72 cm −1 in CoCl 2 only.…”

“…[32][33][34][35] The metal ions used earlier to form different formulations with insulin include silver, copper, zinc, nickel, etc. 31 Apart from metal-insulin nanoparticles, other nano-formulations involving insulin as a wound-healing agent have been synthesized. Insulin-containing chitosan nanoparticles were synthesized to stimulate inammatory cell proliferation, angiogenesis, and wound healing in diabetic rats.…”

A review on terpenes for treatment of gastric cancer: current status and nanotechnology-enabled future

“…For instance, insulin-protected quantum clusters are made using other metal ions, such as nickel, zinc, etc., for their role in developing biomarkers using the green synthesis method. 115,116 Similarly, biomarkers can be developed to detect cancer more precisely & efficiently. 103,117 Coal-GO (graphene oxide) exhibits higher interaction with single-stranded DNA aptamers, resulting in chemiluminescence resonance energy transferbased biosensors with higher sensitivity.…”

Integrated Insulin-Iron Nanoparticless: A Multi-Modal Approach for Receptor-Specific Bioimaging, Reactive Oxygen Species Scavenging, and Wound Healing

“…Notably, there exists a substantial variation in the receptor count, ranging from a mere 40 in erythrocytes to 200-300 × 10 3 in adipocytes and hepatocytes. It's worth highlighting that the number of receptors is markedly higher in cancerous cells compared to their normal [12,13]. Its pivotal function as a growth factor includes aiding chemotaxis and the processes of pinocytosis or phagocytosis by macrophages.…”