A review on terpenes for treatment of gastric cancer: current status and nanotechnology-enabled future

Abstract

Eighty-five percent of gastric cancer is caused by Helicobacter pylori infection. Delays in detection, limited efficacy, and significant side effects of the available treatments lead to 5 years survival chance...

Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases

“…The application of nanoformulation has been shown to enhance the efficacy of cancer treatment by addressing limiting factors such as water insolubility ( Ghanbari-Movahed et al, 2021 ). Terpenoids have also been studied for their potential to improve the effectiveness of gastric cancer treatment by increasing anti-cancer and anti-bacterial efficacy through nanoconjugates, and by addressing shortcomings such as target delivery, stability, and half-life ( Attri et al, 2023 ).…”

Insulin-infused bimetallic nano-subclusters as a multifunctional agent for ROS scavenging, antibacterial resilience, and accelerated in vitro cell migration

“…Here, the role of nanoparticles comes into play as they possess massive potential in diverse fields ranging from drug delivery to bioimaging and wound healing, with anticancer, antimicrobial, and antioxidant activities. 15,16 Many nano-formulations using gold, silver, copper, zinc, and cobalt were developed to study their wound healing, antibacterial and antioxidant properties. 17–19 Recently, protein-based metallic nanoparticles have gained enormous interest because of their target specificity, biodegradability, ability to alter their surface for efficient attachment of the drugs, and easily metabolizable nature.…”

Chitosan-insulin nano-formulations as critical modulators of inflammatory cytokines and Nrf-2 pathway to accelerate burn wound healing

“…Nanoparticle-based insulin delivery has shown enhanced selectivity, sensitivity, and effectiveness compared to free insulin [ 36 – 38 ]. These nanocarriers improve the therapeutic potential of the drug manifold by acting as site-specific delivery agents due to their functionalization with specific moieties, which add to their efficacy [ 39 – 41 ]. This has led to the development of various insulin-based and other antidiabetic protein-based drugs that either improve insulin sensitivity or stimulate increased insulin secretion from the pancreas to treat wounds under normal or diabetic conditions [ 42 – 45 ].…”