Protection of goats against peste des petits ruminants with a vaccinia virus double recombinant expressing the F and H genes of rinderpest virus

Jones, Leslie A.; Giavedoni, Luis D.; Saliki, Jeremiah T.; Brown, Corrie C.; Mebus, Charles A.; Yilma, Tilahun

doi:10.1016/0264-410x(93)90386-c

Cited by 51 publications

(30 citation statements)

References 20 publications

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“…Goats were also protected against a lethal challenge of PPRV following vaccination with a recombinant capripoxvirus containing either the F or H gene of RPV [115]. Similarly recombinant VACV and capripox virus expressing the H and F genes of RPV were reported to protect goats against PPRV challenge [67,115]. Recombinant adenovirus expressing F and H fusion proteins of PPRV induces both humoral and cell-mediated immune responses in goats [157].…”

Section: Recombinant Vaccinesmentioning

confidence: 99%

“…PPRV is antigenically closely related to RPV and antibodies against PPRV are both cross-neutralising and crossprotective [150]. The VACV and capripox expressing H and F glycoproteins PPRV has been shown to protect goats against PPR [67,115]. A VACV double recombinant expressing H and F glycoproteins of RPV has been shown to protect goats against PPR [67] though the animals developed virus-neutralising antibodies only against RPV and not against PPRV.…”

Section: Immunitymentioning

confidence: 99%

“…The VACV and capripox expressing H and F glycoproteins PPRV has been shown to protect goats against PPR [67,115]. A VACV double recombinant expressing H and F glycoproteins of RPV has been shown to protect goats against PPR [67] though the animals developed virus-neutralising antibodies only against RPV and not against PPRV. Capripox recombinants expressing the H or F protein of RPV or the F protein of PPRV conferred protection against PPR in goats, but without production of PPRV-neutralizing antibodies [115] or PPRV antibodies detectable by ELISA [22].…”

Section: Immunitymentioning

confidence: 99%

See 2 more Smart Citations

Diagnosis and control of peste des petits ruminants: a comprehensive review

Balamurugan¹,

Hemadri²,

Gajendragad³

et al. 2013

VirusDis.

131

118

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Peste des petits ruminants (PPR) is an acute, highly contagious, world organization for animal health (OIE) notifiable and economically important transboundary viral disease of sheep and goats associated with high morbidity and mortality and caused by PPR virus. PPR is considered as one of the main constraints in augmenting the productivity of small ruminants in developing countries and particularly severely affects poor farmer's economy. The disease is clinically manifested by pyrexia, oculo-nasal discharges, necrotizing and erosive stomatitis, gastroenteritis, diarrhoea and bronchopneumonia. The disease can be diagnosed from its clinical signs, pathological lesions, and specific detection of virus antigen/antibodies/genome in the clinical samples by various serological tests and molecular assays. PPR is the one of the priority animal diseases whose control is considered important for poverty alleviation in enzootic countries. Availability of effective and safe live attenuated cell culture PPR vaccines and diagnostics have boosted the recently launched centrally sponsored control programme in India and also in other countries. This review article primarily focus on the current scenario of PPR diagnosis and its control programme with advancement of research areas that have taken place in the recent years with future perspectives.

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Section: Recombinant Vaccinesmentioning

confidence: 99%

Section: Immunitymentioning

confidence: 99%

Section: Immunitymentioning

confidence: 99%

See 1 more Smart Citation

Diagnosis and control of peste des petits ruminants: a comprehensive review

Balamurugan¹,

Hemadri²,

Gajendragad³

et al. 2013

VirusDis.

131

118

View full text Add to dashboard Cite

show abstract

“…In the time of RP as the main disease of livestock, a marker vaccine was constructed using a recombinant vaccinia virus. This construct contains the H and F genes of RPV, and was not only protective against RPV but also completely protective against PPRV, although neutralizing antibodies were only detected for RPV (Jones et al 1993). These results indicate that the H and F proteins of RPV are sufficient for cross-protection for PPRV; however, it remained to be determined which protein immune response overwhelms the protection over the other.…”

Section: Heterologous Marker Vaccines For Pprvmentioning

confidence: 96%

Current Advances in Molecular Diagnosis and Vaccines for Peste des Petits Ruminants

Munir

Zohari²,

Berg

2012

Molecular Biology and Pathogenesis of Peste Des Petits Ruminants Virus

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There has been a substantial improvement in the detection of the nucleic acids of Peste des Petits Ruminants Virus (PPRV), and effective vaccines have been developed in recent years. Demonstrations of several real-time PCR assays have provided powerful and novel means of not only detection but also quantification of the nucleic acids of PPRV in several types of clinical samples. Although most of the lineages are continent specific, reports on mixed lineages are emerging, such as in Sudan and Uganda. None of the available assays is devised so far to differentiate all of the lineages. Despite essential advances in the marker vaccines, it is still required to establish reverse genetics systems to rescue recombinant PPRV vaccines, primarily by manipulating the genes of PPRV and insertion of positive or negative markers, which ultimately will lead to the development of companion test. Similarly, swapping different genes will facilitate the establishment of a test that can differentiate vaccinated and infected animals. In this chapter, we discuss available diagnostic tests and potent PPRV vaccines. Furthermore, the current advances in both fields and possibilities to develop next-generation assays and vaccines for PPRV are critically discussed.

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“…The disease, a contagion in goats and sheep, is characterized by severe pyrexia, oculonasal discharges, necrotizing and erosive stomatitis, enteritis and pneumonia [2][3][4] . PPR was initially epidemic in the Ivory Coast, West Africa [5] , and later spread across subSaharan Africa, the Arabian Peninsula and south-west Asia [6] .…”

Section: Introductionmentioning

confidence: 99%

Development of an Indirect ELISA with Artificially Synthesized N Protein of PPR Virus

Zhang¹,

Zeng²,

Zhu³

et al. 2011

Intervirology

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The full-length gene encoding the nucleocapsid (N) protein of the virus (PPRV) responsible for an outbreak of peste des petits ruminants in Tibet in 2007 was synthesized in two stages using overlapping PCR without the need for viral genomic cDNA as template. The full-length N gene was successfully expressed in Escherichia coli, and the purified gene product bound to monoclonal antibody raised against PPRV N protein. Furthermore, it was able to replace recombinant B-N antigen as the coating antigen in a commercial ELISA kit prepared with another PPRV strain. Recombinant protein was employed as the coating antigen to develop an indirect ELISA for PPRV antibody detection in the sera of infected small ruminants. Antibody detection was optimal at a 1:200 serum dilution and an antigen concentration of 3.2 µg/ml, and the positive threshold (cutoff) value of the assay was 2.18. Analysis of 697 serum samples revealed the sensitivity and specificity of the indirect ELISA to be 96.7 and 96.1%, respectively, compared with a commercially available ELISA test.

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Protection of goats against peste des petits ruminants with a vaccinia virus double recombinant expressing the F and H genes of rinderpest virus

Cited by 51 publications

References 20 publications

Diagnosis and control of peste des petits ruminants: a comprehensive review

Diagnosis and control of peste des petits ruminants: a comprehensive review

Current Advances in Molecular Diagnosis and Vaccines for Peste des Petits Ruminants

Development of an Indirect ELISA with Artificially Synthesized N Protein of PPR Virus

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