On 31 December 2019, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, Hubei province, China, and caused the outbreak of the Coronavirus Disease 2019 . To date, computed tomography (CT) findings have been recommended as major evidence for the clinical diagnosis of COVID-19 in Hubei, China. This review focuses on the imaging characteristics and changes throughout the disease course in patients with COVID-19 in order to provide some help for clinicians. Typical CT findings included bilateral ground-glass opacity, pulmonary consolidation, and prominent distribution in the posterior and peripheral parts of the lungs. This review also provides a comparison between COVID-19 and other diseases that have similar CT findings. Since most patients with COVID-19 infection share typical imaging features, radiological examinations have an irreplaceable role in screening, diagnosis and monitoring treatment effects in clinical practice.
Glycerol-3-phosphate acyltransferase (GPAT) mediates the initial synthetic step for the formation of glycerolipids, which act as the major components of biological membranes and the principal stored forms of energy. GPAT6 is a member of the Arabidopsis GPAT family, which is crucial for cutin biosynthesis in sepals and petals. In this work, a functional analysis of GPAT6 in anther development and plant fertility was performed. GPAT6 was highly expressed in the tapetum and microspores during anther development. The knockout mutant, gpat6, caused a massive reduction in seed production. This report shows that the ablation of GPAT6 caused defective tapetum development with reduced endoplasmic reticulum (ER) profiles in the tapetum, which largely led to the abortion of pollen grains and defective pollen wall formation. In addition, pollen germination and pollen tube elongation were affected in the mutant plants. Furthermore, the double mutant analysis showed that GPAT6 and GPAT1 make joint effects on the release of microspores from tetrads and stamen filament elongation. This work shows that GPAT6 plays multiple roles in stamen development and fertility in Arabidopsis.
Esophageal cancer (EC) is a type of aggressive cancer without clinically relevant molecular subtypes, hindering the development of effective strategies for treatment. To define molecular subtypes of EC, we perform mass spectrometry-based proteomic and phosphoproteomics profiling of EC tumors and adjacent non-tumor tissues, revealing a catalog of proteins and phosphosites that are dysregulated in ECs. The EC cohort is stratified into two molecular subtypes—S1 and S2—based on proteomic analysis, with the S2 subtype characterized by the upregulation of spliceosomal and ribosomal proteins, and being more aggressive. Moreover, we identify a subtype signature composed of ELOA and SCAF4, and construct a subtype diagnostic and prognostic model. Potential drugs are predicted for treating patients of S2 subtype, and three candidate drugs are validated to inhibit EC. Taken together, our proteomic analysis define molecular subtypes of EC, thus providing a potential therapeutic outlook for improving disease outcomes in patients with EC.
Smart interactive electronic devices can dynamically respond to and visualize environmental stimuli. Inspired by the rapid color changes of natural creatures, an interactive electronic fiber sensor with high stretchability and tunable coloration is presented. It is based on an ingenious multi-sheath design on a piezoresistive electronic fiber coupled with a mechanochromic photonic crystal microtubule. It has the unique capabilities of sensing and visualizing its deformation simultaneously, by reconstructing conductive paths and regulating the lattice spacing of the photonic sheath. In particular, it exhibits dynamic color switching spanning the full visible region (from red to blue), fast optical/electrical response (≈80 ms), and a large working range (0-200%), allowing its application as a user-interactive sensor for dynamically monitoring large joint movements and muscle microvibrations of the human body in real time. This investigation provides a general platform for emerging interactive devices, which are promising for applications in wearable electronics, human-machine interactions, and intelligent robots.
The full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. and less negative ε Nd(t) (-3.83 to -5.09) and ε Hf(t) (-3.06 to -3.83) than the UCC plus the overlapping isotopes with the mafic dikes and high Nb-Ta rhyolites, the felsic volcanic rocks are best interpreted as resulting from melting-induced mixing with 45-50% crustal materials and 50-55% mantle-derived mafic melts probably parental to the mafic dikes. Such mantle-derived melts underplated and intruded the deep crust as juvenile crustal materials. Partial melting of such juvenile crust produced felsic melts parental to the felsic volcanic rocks in the EKOB. We hypothesize that the late A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPTTriassic mafic dikes and felsic volcanic rocks are associated with post-collisional extension and related orogenic collapse. Such processes are probably significant in causing asthenospheric upwelling, decompression melting, induced melting of the prior metasomatized mantle lithosphere and the existing crust. This work represents our ongoing effort in understanding the origin of the juvenile crust and continental crustal accretion through magmatism in the broad context of orogenesis from seafloor subduction to continental collision and to post-collisional processes.
The postoperative recurrence rate of intravenous leiomyomatosis was high, and large vein involvement was associated with an increased risk of recurrence. Continued postoperative follow-up is important. Neither resection of bilateral ovaries nor postoperative hormone therapy was associated with recurrence.
Two new antiarchs are described, from the Late Devonian Hunter Siltstone near Grenfell in southeastern Australia (Grenfellaspis branagani n.gen., n.sp.), and from the Early-Middle Devonian Dayaoshan Group in Guangxi, southeastern China (Dayaoshania youngi n.gen., n.sp.). New material is described of Xichonolepis qujingensis P'an & Wang, 1978 from the Middle Devonian of Yunnan, and new interpretations are presented for Sinolepis Liu & P'an, 1958 from the Late Devonian of Jiangsu. All four genera are placed in the family Sinolepidae Liu & P' an, of which the most obvious defining character is the much reduced ventral laminae of the anterior and posterior ventrolateral plates of the trunk armour, and the presumed absence of a median ventral plate. Emended diagnoses are presented for the family Sinolepidae and the genera Xichonolepis and Sinolepis. It is suggested that Grenfellaspis and Sinolepis are immediately related, and the biostratigraphic, biogeographic, and palaeogeographic implications of this relationship are discussed. The vertebrate fauna from the Hunter Siltstone is regarded as the youngest nonmarine vertebrate horizon known from the Devonian of southeastern Australia. A close palaeogeographic connection between southeastern Australia and South and North China is indicated for the latest Devonian and earliest Carboniferous (late Famennian-early Tournaisian), which contrasts with the distinctive Devonian vertebrate faunas from the two regions in earlier strata. Other Devonian fossil groups showing a similar biogeographic pattern are considered in the context of competing hypotheses concerning the palaeogeographic relationships of Gondwana and Asia during the Middle Palaeozoic.
Accessible chromatin is a highly informative structural feature for identifying regulatory elements, which provides a large amount of information about transcriptional activity and gene regulatory mechanisms. Human ATAC-seq datasets are accumulating rapidly, prompting an urgent need to comprehensively collect and effectively process these data. We developed a comprehensive human chromatin accessibility database (ATACdb, http://www.licpathway.net/ATACdb), with the aim of providing a large amount of publicly available resources on human chromatin accessibility data, and to annotate and illustrate potential roles in a tissue/cell type-specific manner. The current version of ATACdb documented a total of 52 078 883 regions from over 1400 ATAC-seq samples. These samples have been manually curated from over 2200 chromatin accessibility samples from NCBI GEO/SRA. To make these datasets more accessible to the research community, ATACdb provides a quality assurance process including four quality control (QC) metrics. ATACdb provides detailed (epi)genetic annotations in chromatin accessibility regions, including super-enhancers, typical enhancers, transcription factors (TFs), common single-nucleotide polymorphisms (SNPs), risk SNPs, eQTLs, LD SNPs, methylations, chromatin interactions and TADs. Especially, ATACdb provides accurate inference of TF footprints within chromatin accessibility regions. ATACdb is a powerful platform that provides the most comprehensive accessible chromatin data, QC, TF footprint and various other annotations.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.