Protection and targeted delivery of β-carotene by starch-alginate-gelatin emulsion-filled hydrogels

Silva, Karen Cristina Guedes; Feltre, Gabriela; Hubinger, Míriam Dupas; Sato, Ana Carla Kawazoe

doi:10.1016/j.jfoodeng.2020.110205

Cited by 51 publications

(18 citation statements)

References 39 publications

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“…As such, many novel hydrogel-based delivery matrices have been designed for pharmaceutical and medical fields, playing a vital role in diagnosis and treatment [ 16 , 17 , 18 ]. Recently, hydrogels have been explored in other areas, such as tissue engineering, cosmetics, and food technology, with an increasing number of publications on the subject [ 19 , 20 , 21 , 22 , 23 , 24 ].…”

Section: Hydrogels Oleogels Bigels and Emulgelsmentioning

confidence: 99%

Oleogel-Based Systems for the Delivery of Bioactive Compounds in Foods

Pinto

Martins

Pastrana

et al. 2021

Gels

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Oleogels are semi-solid materials containing a large fraction of liquid oil entrapped in a network of structuring molecules. In the food industry, these formulations can be used to mimic fats and to deliver bioactive compounds. In the last decade, there has been increasing interest in these structures, not only from a scientific point of view, i.e., studying new molecules, methodologies for gelification, and new structures, but also from a technological point of view, with researchers and companies exploring these structures as a way to overcome certain challenges and/or create new and innovative products. One of the exciting applications of oleogels is the delivery of functional molecules, where the incorporation of oil-soluble functional compounds can be explored not only at the macroscale but also at micro- and nanoscales, resulting in different release behaviors and also different applications. This review presents and discusses the most recent works on the development, production, characterization, and applications of oleogels and other oleogel-based systems to deliver functional molecules in foods.

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Section: Hydrogels Oleogels Bigels and Emulgelsmentioning

confidence: 99%

Oleogel-Based Systems for the Delivery of Bioactive Compounds in Foods

Pinto

Martins

Pastrana

et al. 2021

Gels

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“…Similarly, alginate with these eminent properties can also be cross-linked with other natural or synthetic materials to fabricate a wide range of different alginatebased nutraceutical carriers, such as hydrogel, emulsion, nanoparticle, microparticle and so forth (Guedes Silva et al, 2021;Khan et al, 2019). Compared to other carriers, the alginate-based delivery system possesses numerous pronounced advantages, such as alginate hydrogel delivery systems with improved physical as well as mechanical properties (swelling, particle size, viscosity, etc.)…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the alginate-based delivery system can preserve susceptible bioactive components against relatively adverse environmental conditions (strong acidity, oxygen, bacteria, UV light, etc.) (Guedes Silva et al, 2021), exhibit good encapsulation efficiency (EE) and loading capacity (LC) of bioactive ingredients (Zhang et al, 2019). Therefore, there is an increasing interest in the development of alginate-based delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Alginate‐based delivery systems for food bioactive ingredients: An overview of recent advances and future trends

Wei

Xue

2021

Comp Rev Food Sci Food Safe

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Due to its advantagessuch as ionic crosslinking, pH responsiveness, excellent biocompatibility, biodegradability and low price, alginate has become one of the most important natural polysaccharides extensively used in constructing desired delivery systems for food bioactive ingredients. In this review, the fundamental knowledge of alginate as a building block for construction of nutraceutical delivery systems is introduced. Then, various types of alginate-based nutraceutical delivery systems are classified and summarized. Furthermore, the future trends of alginate-based delivery systems are highlighted. Currently, alginate-based delivery systems include hydrogel, emulsion, emulsion-filled alginate hydrogel, nanoparticle, microparticle, core-shell particle, liposome, edible film, and aerogel. Although alginate has been widely used in the fabrication of food bioactive ingredient delivery systems, further efforts and improvements are still needed. For this purpose, the future perspectives of alginate-based delivery systems are discussed. The feasible research trends of alginate-based delivery systems include the development of novel large-scale commercial preparation technology, multifunctional delivery system based on alginate, alginate oligosaccharide-based delivery system and alginate-based oleogel. Overall, the objective of this review is to provide useful guidance for rational design and application of alginate-based nutraceutical delivery systems in the future.

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“…It has excellent biocompatibility, non-toxicity, and immunogenicity, owing to which it has been widely used for the delivery of bioactive substances [ 15 , 16 , 17 , 18 ]. However, there are still some limitations associated with the use of an alginate-gel based delivery system: alginate-based gel microspheres are highly porous and show a weak network, low adherence, and high burst release properties [ 19 ]. Fortunately, blending SA with other polymers is an effective method to circumvent these problems.…”

Section: Introductionmentioning

confidence: 99%

The Layered Encapsulation of Vitamin B2 and β-Carotene in Multilayer Alginate/Chitosan Gel Microspheres: Improving the Bioaccessibility of Vitamin B2 and β-Carotene

Liao

Dai

Lian

et al. 2021

Foods

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This research underlines the potential of alginate multilayered gel microspheres for the layered encapsulation and the simultaneous delivery of vitamin B2 (VB) and β-carotene (BC). Chitosan was used to improve the stability and controlled release ability of alginate-based gel microspheres. It was shown that a clear multilayered structure possessed the characteristics of pH response, and excellent thermal stability. The sodium alginate concentration and the number of layers had notable effects on mechanical properties and particle size of gel microspheres. Fourier-transform infrared spectroscopy and X-ray diffraction analyses further proved that VB and BC were encapsulated within the gel microspheres. Compared with the three-layer VB-loaded gel microspheres, the total release of VB from the three-layer VB and BC-loaded gel decreased from 93.23 to 85.58%. The total release of BC from the three-layer VB and BC-loaded gel increased from 66.11 to 69.24% compared with three-layer BC-loaded gel. The simultaneous encapsulation of VB and BC in multilayered gel microspheres can markedly improve their bioaccessibility and bioavailability. These results showed the multilayer gel microspheres synthesized herein have potential for applications in the layered encapsulation and simultaneous delivery of various bioactive substances to the intestinal tract.

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Protection and targeted delivery of β-carotene by starch-alginate-gelatin emulsion-filled hydrogels

Cited by 51 publications

References 39 publications

Oleogel-Based Systems for the Delivery of Bioactive Compounds in Foods

Oleogel-Based Systems for the Delivery of Bioactive Compounds in Foods

Alginate‐based delivery systems for food bioactive ingredients: An overview of recent advances and future trends

The Layered Encapsulation of Vitamin B2 and β-Carotene in Multilayer Alginate/Chitosan Gel Microspheres: Improving the Bioaccessibility of Vitamin B2 and β-Carotene

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