Alginate‐based delivery systems for food bioactive ingredients: An overview of recent advances and future trends

Abstract

Due to its advantagessuch as ionic crosslinking, pH responsiveness, excellent biocompatibility, biodegradability and low price, alginate has become one of the most important natural polysaccharides extensively used in constructing desired delivery systems for food bioactive ingredients. In this review, the fundamental knowledge of alginate as a building block for construction of nutraceutical delivery systems is introduced. Then, various types of alginate-based nutraceutical delivery systems are classified and summarized. Furthermore, the future trends of alginate-based delivery systems are highlighted. Currently, alginate-based delivery systems include hydrogel, emulsion, emulsion-filled alginate hydrogel, nanoparticle, microparticle, core-shell particle, liposome, edible film, and aerogel. Although alginate has been widely used in the fabrication of food bioactive ingredient delivery systems, further efforts and improvements are still needed. For this purpose, the future perspectives of alginate-based delivery systems are discussed. The feasible research trends of alginate-based delivery systems include the development of novel large-scale commercial preparation technology, multifunctional delivery system based on alginate, alginate oligosaccharide-based delivery system and alginate-based oleogel. Overall, the objective of this review is to provide useful guidance for rational design and application of alginate-based nutraceutical delivery systems in the future.

Applications of Chitosan-Alginate-Based Nanoparticles—An Up-to-Date Review

“…Alginate also exhibits mucoadhesive properties and, in contrast to chitosan, it is also water-soluble. In addition, studies have shown that alginate-based substances are pH-sensitive, being a useful tool for controlling the release of encapsulated biomolecules [26,47,[52][53][54]. Alginate is a promising candidate material for the oral, ocular, nasal, parenteral, and mucosal drug delivery of various moieties, including nucleic acids, drugs, and vaccine formulations [55][56][57][58][59].…”

Application of Alginate-Based Hydrogels in Hemostasis

“…Alginate has been approved by the FDA as a material generally recognized as safe (GRAS) without special restrictions. Since the 1980s, the applications of alginate have rapidly expanded in food, chemical, printing, agriculture and medicine [24,[30][31][32]. Alginic acid is insoluble in water, however the sodium alginate forms after binding Na+ can be completely dissolved in water.…”

“…Alginate has been approved by the FDA as a material generally recognized as safe (GRAS) without special restrictions. Since the 1980s, the applications of alginate have rapidly expanded in food, chemical, printing, agriculture and medicine [ 24 , 30 , 31 , 32 ].…”

Microencapsulating Alginate-Based Polymers for Probiotics Delivery Systems and Their Application

“…Alternatively, sodium alginate is a polysaccharide commonly used to formulate edible coatings because of its biodegradability, biocompatibility, low toxicity, and film-forming properties [ 47 ], which exhibit great value in storage. A recent study showed that loading potential probiotic fruit-derived lactic acid bacteria (LAB) strains into sodium alginate (SA) coating could effectively reduce the anthracnose lesion development in guava and mango contaminated with either of the tested Colletotrichum strains during storage [ 41 ], which can significantly improve the overall postharvest quality and long storage resistance of fruits [ 41 ].…”