Prostatic Hemangiosarcoma in a Dog: Clinical and Pathologic Findings

Abstract

Prostatic hemangiosarcoma (HS) appears to be rare in the dog. 5 In 3 of 4 previously reported cases, the prostate was involved via metastasis. 7,10,11 For 1 dog, the primary tumor presumably was located in the prostate gland, but no details were given. 3 The present report documents what we believe is a primary HS of the prostate in a dog that presented with clinical signs of urinary tract disease. The prostate tumor and metastases had microscopic features of a poorly differentiated HS, and the diagnosis was confirmed by immunohistochemistry.An 11-year-old male Miniature poodle was admitted to a veterinary hospital because of straining to urinate and defecate and passing "ribbon-like" feces for approximately 1 month. Physical examination revealed prostatomegaly. The dog was castrated and given an injection of 0.25 mg of estradiol cypionate a intramuscularly. Clinical signs persisted, and the dog was referred to the University of Minnesota Veterinary Teaching Hospital (UMVTH) 6 days after castration.Physical examination revealed a thin dog with prostatomegaly and a very distended urinary bladder. A complete blood count revealed a normochromic normocytic anemia (PCV = 23%, normal > 37%) without significant regenerative response. The dog was catheterized without difficulty, and 225 ml of yellow urine were removed. A urinalysis was consistent with urinary tract infection, and a urine culture revealed Klebsiella pneumoniae and Proteus mirabilis (> 10 5 colony forming units/ml). Prostatomegaly was identified on abdominal radiographs. A sonogram revealed diffuse prostatic hyperechogenicity with irregular multifocal hypoechoic masses.A prostatic biopsy was performed with a Tru-Cut biopsy needle b via a perineal approach. Microscopic examination revealed neoplastic polyhedral and spindle cells of uncertain tissue type. Following a course of radiation therapy, which failed to shrink the prostate, the dog was euthanized.At necropsy, the prostate gland protruded from the cranial rim of the pelvis and was tightly adhered to the pelvic canal, especially on the right side. Although both lobes of the prostate were enlarged, the right lobe was more severely affected. The prostate was 10.5 x 6.0 x 4.0 cm and weighed 125 g. Transverse sections of the prostate revealed a large yellow core encircled by a rim of red tissue. Reddish-yellow tissue was present within the right obturator foramen. Soft red and white nodules 0.7 cm and 4 cm in diameter were found in the left and right medial thigh muscles, respectively.From the

Multimodality imaging of primary ureteral hemangiosarcoma with thoracic metastasis in an adult dog

“…In two published cases, hemangiosarcoma was localized into the retroperitoneal space; the first one encircled the aorta and the second one compressed the left and right iliac veins . A few reported cases of primary hemangiosarcoma have been localized to the prostatic gland, urethra, and uterine remnant in spayed female dogs However, a primary site of hemangiosarcoma is considered to be rare in the canine urinary tract and reproductive system …”

Aspectos epidemiológicos e anatomopatológicos do hemagiossarcoma em cães: 40 casos (1965-2012)

“…Na literatura internacional, o baço é frequentemente descrito como o órgão mais afetado pelo hemangiossarcoma (Hirsch et al 1981, Brown et al 1985, Schultheiss 2004, Sabattini & Bettini 2009), exceto, é claro, no estudo de Kleine et al (1970), como já discutido previamente. Semelhante ao que observamos, apenas esporadicamente outros órgãos são descritos na literatura como estando envolvidos em casos de hemangiossarcoma (Brown et al 1985, Hayden et al 1992, Sabattini & Bettini 2009. O frequente envolvimento concomitante de órgãos como coração e baço em cães afetados por hemangiossarcoma tem levado muitos autores a discutirem uma possível origem multicêntrica para esse neoplasma (Goldschmidt & Hendrick 2002).…”

Predominance of hypoechoic tissue changes in nine dogs with malignant prostatic lymphoma

“…Tumors of nonepithelial origin are particularly rare within the prostatic gland . Fibrosarcoma, leiomyosarcoma, leiomyoma, and hemangiosarcoma have been identified in the canine prostate . Only individual cases of malignant lymphoma affecting the prostate in dogs have been reported so far .…”

“…3 Fibrosarcoma, leiomyosarcoma, leiomyoma, and hemangiosarcoma have been identified in the canine prostate. [3][4][5][6][7] Only individual cases of malignant lymphoma affecting the prostate in dogs have been reported so far. [8][9][10][11] Canine malignant lymphoma is typically a multicentric disease, even though on occasion the lymphomatous neoplastic infiltrate is limited to one organ as in extranodal presentations.…”