Prostate-Specific Antigen Monitoring Using Nano Zinc(II) Metal–Organic Framework-Based Optical Biosensor

Abstract

Background: The prostate-specific antigen (PSA) is an important cancer biomarker that is commonly utilized in the diagnosis of prostate cancer. The development of a PSA determination technique that is rapid, simple, and inexpensive, in addition to highly accurate, sensitive, and selective, remains a formidable obstacle. Methods: In this study, we developed a practical biosensor based on Zn(II) metal–organic framework nanoparticles (Zn-MOFs-NPs). Many spectroscopic and microanalytical tools are used to determine the structure, morphology, and physicochemical properties of the prepared MOF. Results: According to the results, Zn-MOFs-NPs are sensitive to PSA, selective to an extremely greater extent, and stable in terms of chemical composition. Furthermore, the Zn-MOFs-NPs did not exhibit any interferences from other common analytes that might cause interference. The detection limit for PSA was calculated and was 0.145 fg/mL throughout a wide linear concentration range (0.1 fg/mL–20 pg/mL). Conclusions: Zn-MOFs-NPs were successfully used as a growing biosensor for the monitoring and measurement of PSA in biological real samples.

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“…The prostate-specific antigen (PSA), a glycoprotein of 237 amino acids that are released by the prostate gland, is the most important and common biomarker for prostate cancer. A biosensor based on Zn(II) metal–organic framework NPs can detect the PSA at a detection limit of 0.145 fg/mL where the PSA concentration > 10 ng/mL is considered a threat for suspected prostate cancers [ 206 ]. The antibodies against PSA and prostate-specific membrane antigen (PSMA) were decorated on Fe 3 O 4 nanoparticles which are loaded onto graphene oxide (GO) nano-sheets for microfluidic immunoarray based on electrochemical reaction [ 207 ].…”

Microfluidic Platform Integrated with Carbon Nanofibers-Decorated Gold Nanoporous Sensing Device for Serum PSA Quantification

“…This pathology is one of the most common cancer types suffered by men, with an increasing incidence and mortality rate worldwide [ 20 , 21 ]. The etiology of PC has not been completely elucidated, although several factors could be associated with it, including aging, family history, and genetic mutations [ 20 , 22 , 23 ].…”