Prostaglandin influence on pulmonary intravascular leukocytic aggregation during cardiopulmonary bypass

Bolanowski, Paul J.P.; Bauer, James L.; Machiedo, George W.; Neville, William E.; Nolan, Lovone

doi:10.1016/s0022-5223(19)39949-0

Cited by 42 publications

(7 citation statements)

References 6 publications

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“…merit and therefore should be maintained in the physiological range, in particular when capillary permeability is increased [10]. However, with the onset of cardiopulmonary bypass, the plasma is diluted by the prime volume of the machine and colloid osmotic pressure may decrease considerably, depending on the composition of the priming solution [1,2,6,[11][12][13][14]. Addition of colloids to the pump prime solution has been advocated, therefore, by several groups.…”

mentioning

confidence: 99%

Priming of Cardiopulmonary Bypass With Human Albumin or Ringer Lactate: Effect on Colloid Osmotic Pressure and Extravascular Lung Water

Hoeft

Korb²,

Mehlhorn³

et al. 1991

British Journal of Anaesthesia

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We have undertaken a randomized study on 20 patients undergoing coronary artery bypass surgery in order to determine the influence of cardiopulmonary pump prime solutions on colloid osmotic pressure and extravascular lung water. Crystalloid priming with Ringer lactate was compared with an albumin solution of nearly physiological colloid osmotic composition (4%). Measurements of extravascular lung water were performed by a modified, highly sensitive thermal dye technique, with additional detection of tracer signals in the pulmonary artery. In the Ringer lactate group, a significantly greater decrease in colloid osmotic pressure occurred immediately after onset of cardiopulmonary bypass. The more pronounced decrease in colloid osmotic pressure and in transcapillary gradient (difference between colloid osmotic pressure and pulmonary capillary wedge pressure) in the Ringer lactate group was associated with a significant increase in extravascular lung water (by 60%) in the postoperative period; the human albumin group, however, showed only a slight tendency to increased lung water. There were no differences in haemodynamic or respiratory states after operation.

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mentioning

confidence: 99%

Priming of Cardiopulmonary Bypass With Human Albumin or Ringer Lactate: Effect on Colloid Osmotic Pressure and Extravascular Lung Water

Hoeft

Korb²,

Mehlhorn³

et al. 1991

British Journal of Anaesthesia

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“…Potential benefits from the exclusion of artificial oxygenators include the following. First, the lungs are kept perfused, which allows them to function in the homeostatic prostaglandin and thromboxane balance ( 15, 16). Second, lung perfusion avoids tissue anoxia that produces leukoplaquetary aggregation and capillary obstruction and ensuing respiratory distress ( 17).…”

Section: Discussionmentioning

confidence: 99%

A Simplified Single Pump Circuit for Cardiac Bypass with Autogenous Oxygenation

Marques

Cestari

et al. 1999

Artificial Organs

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A simplified extracorporeal circulation (ECC) assemblage with autogenous oxygenation (AO) using a single centrifugal pump was tested in dogs. The transpulmonary gradient was obtained by increasing pressure in the right atrium through volume expansion and decreasing it in the left atrium by collecting the blood from the pulmonary veins in a reservoir placed below the level of the animal, generating a siphon effect. This arrangement dispenses with a right side pump. The heart was electrically fibrillated after perfusion was started and defibrillated at the end of the bypass. This ECC circuit allowed the maintenance of adequate hemodynamic and blood gas parameters during the bypass. The operating field and the mobility of the heart were equivalent to that of conventional cardiopulmonary bypass (CPB). We conclude that the use of a single centrifugal pump simplifies the autogenous oxygenation approach, making it a practical choice for the coronary artery bypass graft (CABG) procedure.

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“…• Os pulmões são mantidos perfundidos, o que lhes permite atuar nos mecanismos homeostáticos e no balanço da prostaglandina e do tromboxane (15,16) .…”

Section: Comentáriosunclassified

“…Sabe-se que desse contato decorre a ativação de complemento e daí deficiência pulmonar com diminuição da função plaquetária (18)(19)(20) . O fenômeno se dá tanto com o emprego oxigenadores de membrana como nos de bolhas (16) .…”

Section: Comentáriosunclassified

Um circuito simples com bomba única para circulação extracorpórea com oxigenação autógena

Marques¹,

Cestari²,

Cestari³

et al. 2002

Rev Bras Cir Cardiovasc

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Prostaglandin influence on pulmonary intravascular leukocytic aggregation during cardiopulmonary bypass

Cited by 42 publications

References 6 publications

Priming of Cardiopulmonary Bypass With Human Albumin or Ringer Lactate: Effect on Colloid Osmotic Pressure and Extravascular Lung Water

Priming of Cardiopulmonary Bypass With Human Albumin or Ringer Lactate: Effect on Colloid Osmotic Pressure and Extravascular Lung Water

A Simplified Single Pump Circuit for Cardiac Bypass with Autogenous Oxygenation

Um circuito simples com bomba única para circulação extracorpórea com oxigenação autógena

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