Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes

Jończyk‐Matysiak, Ewa; Weber‐Dąbrowska, Beata; Żaczek, Maciej; Międzybrodzki, Ryszard; Letkiewicz, Sławomir; Łusiak-Szelchowska, Marzanna; Górski, Andrzej

doi:10.3389/fmicb.2017.00164

Cited by 37 publications

(49 citation statements)

References 96 publications

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“…Topical probiotics may also include C. acnes bacteriophages, which are viruses that can lyse host bacteria. Two studies showed that some C. acnes bacteriophages lyse only acne‐associated and uncorrelated (potentially pathogenic) phylotypes, but are often ineffective against phylotypes associated with healthy skin . This potential combination of healthy‐skin‐associated C. acnes together with bacteriophages that target other C. acnes could potentially allow for highly specific strain replacement (Fig.…”

Section: Methodsmentioning

confidence: 99%

Changing our microbiome: probiotics in dermatology

et al. 2019

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Summary Background Commensal bacteria are a major factor in human health and disease pathogenesis. Interest has recently expanded beyond the gastrointestinal microbiome to include the skin microbiome and its impact on various skin diseases. Objectives Here we present current data reviewing the role of the microbiome in dermatology, considering both the gut and skin microflora. Our objective was to evaluate whether the clinical data support the utility of oral and topical probiotics for certain dermatological diseases. Methods The PubMed and ClinicalTrials.gov databases were searched for basic science, translational research and clinical studies that investigated differences in the cutaneous microbiome and the impact of probiotics in patients with atopic dermatitis, acne vulgaris, psoriasis, chronic wounds, seborrhoeic dermatitis and cutaneous neoplasms. Results Few clinical trials exist that explore the utility of probiotics for the prevention and treatment of dermatological diseases, with the exception of atopic dermatitis. Most studies investigated oral probiotic interventions, and of those utilizing topical probiotics, few included skin commensals. In general, the available clinical trials yielded positive results with improvement of the skin conditions after probiotic intervention. Conclusions Oral and topical probiotics appear to be effective for the treatment of certain inflammatory skin diseases and demonstrate a promising role in wound healing and skin cancer. However, more studies are needed to confirm these results. What's already known about this topic? The microbiome plays a role in human health and disease pathogenesis. Probiotics can manipulate the host microbiome and may confer health benefits for patients. Research to date has already begun to explore the utility of oral and topical probiotics for certain dermatological diseases. What does this study add? This review presents basic science and clinical trial data to support the role of the gut and skin microbiome in dermatology. Current data are reviewed on the use of probiotics in the prevention and treatment of skin diseases, including atopic dermatitis, acne vulgaris, psoriasis, seborrhoeic dermatitis, chronic wounds and cutaneous neoplasms. Future probiotic interventions are proposed.

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Section: Methodsmentioning

confidence: 99%

Changing our microbiome: probiotics in dermatology

et al. 2019

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“…Further support for a role for C. acnes is that acne prevalence decreases with increasing age, likely as a result of decreased sebum production with age, but the change in sebum secretion may be linked to changes in microbiome composition. Although there is promising evidence for the use of lytic formulations with bacteriophages for reducing C. acnes growth in vitro , substantial future work will be required to prove the utility of bacteriophage for treating human acne …”

Section: Acne and Skin Bacteriamentioning

confidence: 99%

“…Although there is promising evidence for the use of lytic formulations with bacteriophages for reducing C. acnes growth in vitro, substantial future work will be required to prove the utility of bacteriophage for treating human acne. 39,40 While much evidence exists supporting the role of C. acnes in acne, the topic remains controversial. C. acnes is also considered a host-beneficial microbe.…”

Section: Acne and Skin Bacteriamentioning

confidence: 99%

The role of the skin microbiota in acne pathophysiology

et al. 2019

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Summary Background The role of skin microbiota in acne remains to be fully elucidated. Initial culture‐based investigations were hampered by growth rate and selective media bias. Even with less biased genomic methods, sampling, lysis and methodology, the task of describing acne pathophysiology remains challenging. Acne occurs in sites dominated by Cutibacterium acnes (formerly Propionibacterium acnes) and Malassezia species, both of which can function either as commensal or pathogen. Objectives This article aims to review the current state of the art of the microbiome and acne. Methods The literature regarding the microbiome and acne was reviewed. Results It remains unclear whether there is a quantitative difference in microbial community distribution, making it challenging to understand any community shift from commensal to pathogenic nature. It is plausible that acne involves (i) change in the distribution of species/strains, (ii) stable distribution with pathogenic alteration in response to internal (intermicrobe) or external stimuli (host physiology or environmental) or (iii) a combination of these factors. Conclusions Understanding physiological changes in bacterial species and strains will be required to define their specific roles, and identify any potential intervention points, in acne pathogenesis and treatment. It will also be necessary to determine whether any fungal species are involved, and establish whether they play a significant role. Further investigation using robust, modern analytic tools in longitudinal studies with a large number of participants, may make it possible to determine whether the microbiota plays a causal role, is primarily involved in exacerbation, or is merely a bystander. It is likely that the final outcome will show that acne is the result of complex microbe–microbe and community–host interplay.

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“…Then Triethanolamine was added dropwise until the gel consistency and pH is adjusted between 6.8 to 7.4. The final volume was made up to 200g by the addition of distilled water [9][10][11][12][13][14][15][16][17][18][19]. Physical evaluation of gel.…”

Section: Formulation Of Gelmentioning

confidence: 99%

“…Food intake was measured on each day. All animals were divided into four groups [19][20][21]. Histopathology Study.…”

Section: Procedurementioning

confidence: 99%

Polyherbal anti acne gel containing extracts of Mangifera indica and Syzygium cumini seeds: bioassay guided activity against Propionibacterium acne

2019

Biointerface Res Appl Chem

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Mangifera indica and Sygygium cumini seeds are rich sources of secondary metabolites and a sustainable cost effective biomaterial. An effective herbal therapy for topical affliction, Acne using such material will prove to be a good alternative to costly and clinically significant antibiotics. The aim of the study was to develop topical polyherbal gel from Mangifera indica and Syzygium cumini for the treatment of acne vulgaris. Plant materials were extracted in methanol and fractionated in different polarity solvents. These fraction were evaluated for antibacterial activity against Propionibacterium acne (P. acne) in-vitro. The most effective fraction was formulated as gel. The formulated gel was evaluated for physico chemical parameters, irritancy, antiacne activity and stability. Methanolic extract was the most active in-vitro against Propionibacterium acne (MTCC 1951). The fabricated gel showed non-stickiness and no irritancy. It showed comparable efficacy as that of clindamycin gel as shown by histopathological study. It also showed the comparable antiacne activity as that of clindamycin gel shown in acne induced wistar albino rats. The formulated gel was stable over a period of 6 months at accelerated stability conditions. It was concluded from the study that methanolic extract of Mangifera indica and Syzygium cumini seeds can be formulated in an aqueous based gel system for topical therapy of mild Acne vulgaris to obtained similar efficacy as that of antibacterial gel (clindamycin) taken as reference standard without its side effects.

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Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes

Cited by 37 publications

References 96 publications

Changing our microbiome: probiotics in dermatology

Changing our microbiome: probiotics in dermatology

The role of the skin microbiota in acne pathophysiology

Polyherbal anti acne gel containing extracts of Mangifera indica and Syzygium cumini seeds: bioassay guided activity against Propionibacterium acne

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