Prospects of Non-drug Approaches to Alzheimer's Disease

Манухина, Е. Б.; Wiegant, F. A. C.; Торшин, В. И.; Goryacheva, Anna V.; Khomenko, I. P.; Kruglov, S. V.; Mashina, S. Yu.; Pokidyshev, D. A.; Popkova, E. A.; Pshennikova, M. G.; Vlasova, M. A.; Zelenina, O. M.; Malyshev, I. Yu.

doi:10.1023/b:bibu.0000036943.66185.50

Cited by 4 publications

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“…Immobilization for 3 h signifi cantly decreased the level of plasma nitrites (Table 1) indicating defi ciency of NO in the blood plasma of stressed rats. This observation agrees with published data on the effect of stress on NO production: long-term and severe stress resulted in defi ciency of NO in the organism, which attests to collapse of the stress-control systems and disadaptation of the organism to the stressor [8][9][10].…”

Section: Resultssupporting

confidence: 91%

“…Currently, NO generating system is considered as a special stress-limiting system activated when the organism is subjected to various stress factors or during adaptation to the repetitive action of environmental challenges [8,9].…”

mentioning

confidence: 99%

“…The study of the effect of various stressors on NO synthesis resulted in a widely spread view that the decrease in serum NO concentration refl ects disadaptation of the organism to stress, while enhanced NO deposition in the vascular endothelium attest to adaptation of the organism to the stress factors [5,[8][9][10].…”

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confidence: 99%

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Effect of Terahertz Electromagnetic Irradiation at Nitric Oxide Frequencies on Concentration of Nitrites in Blood Serum of Albino Rats under Conditions of Immobilization Stress

et al. 2010

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Section: Resultssupporting

confidence: 91%

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confidence: 99%

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Effect of Terahertz Electromagnetic Irradiation at Nitric Oxide Frequencies on Concentration of Nitrites in Blood Serum of Albino Rats under Conditions of Immobilization Stress

et al. 2010

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“…It goes up globally, and it is expected to become one of the most serious disease in global burden of diseases by the year 2030, because it already affects about 40% of people over 85 years old . Alzheimer's and Parkinson's diseases belong among these types of neuropsychiatric illnesses as well ,. The currently available antidepressants face challenges, namely refractoriness, absolute recovery, illness restoring, delay in action development, sexual dysfunction, changes of body weight or cardiovascular and gastrointestinal difficulty ,.…”

Section: Introductionmentioning

confidence: 99%

Plant Adaptogens: Natural Medicaments for 21^stCentury?

et al. 2018

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This review is devoted to adaptogens, plant products capable of producing nonspecific responses in the human body, resulting in increasing the resistance against multiple stressors (physical, chemical or biological) and capable of having a normalizing effect to the human body. Adaptogens must be non-toxic, harmless, capable of not influencing normal body functions more than required, and capable of treating depression, a common neuropsychiatric illness, the importance of which is increasing by number of new patients every year. Number of plants are able to produce natural compounds, which meet the criteria of becoming adaptogens. The most known of them are used in traditional medicine for centuries.

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“…The efficiency of adaptation to diet, physical exercises, and mental exercises is proven. The protective effect of these types of adaptation is based on the expression of cytoprotective stress-proteins HSP, limitation of oxidative stress, inhibition of apoptosis, and even stimulation of neurogenesis in adult human brain [2].…”

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Role of Nitric Oxide in Prevention of Cognitive Disorders in Neurodegenerative Brain Injuries in Rats

et al. 2008

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NO synthesis disturbances play an important role in the development of neurodegenerative damage in Alzheimer disease. We previously showed that adaptation to intermittent hypobaric hypoxia prevents cognitive disturbances in rats with experimental Alzheimer disease. Here we evaluated the role of NO in cognitive disorders and development of adaptive protection during experimental Alzheimer disease. Adaptation to hypoxia in rats was performed in a hypobaric pressure chamber at a simulated altitude of 4000 m (4 h per day for 14 days). Alzheimer disease was simulated by bilateral injections of a toxic fragment of beta-amyloid (25-35) into n. basalis magnocellularis. For evaluation of the role of NO in the development and prevention of memory disorders, the rats received intraperitoneally either NO-synthase inhibitor N omega-nitro-L-arginin (L-NNA, 20 mg/kg, every other day for 14 days) or NO-donor dinitrosyl iron complex (200 microg/kg daily for 14 days). NO-synthase inhibitor potentiated the damaging effect of beta-amyloid, abolished the protective effect of adaptation to hypoxia, and produced memory disorders in rats similar to those observed during experimental Alzheimer disease. In contrast, the increase in NO level in the body provided by injections of the NO-donor produced a protective effect against memory disorders caused by beta-amyloid similar to that induced by adaptation to hypoxia. We concluded that reduced NO production in the organism plays an important role in the development of cognitive disorders produced by injections of beta-amyloid, while prevention of NO deficit by administration of NO-donors or non-pharmacological stimulation of NO synthesis can provide a protective effect in experimental Alzheimer disease.

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Prospects of Non-drug Approaches to Alzheimer's Disease

Cited by 4 publications

References 104 publications

Effect of Terahertz Electromagnetic Irradiation at Nitric Oxide Frequencies on Concentration of Nitrites in Blood Serum of Albino Rats under Conditions of Immobilization Stress

Effect of Terahertz Electromagnetic Irradiation at Nitric Oxide Frequencies on Concentration of Nitrites in Blood Serum of Albino Rats under Conditions of Immobilization Stress

Plant Adaptogens: Natural Medicaments for 21^stCentury?

Role of Nitric Oxide in Prevention of Cognitive Disorders in Neurodegenerative Brain Injuries in Rats

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Prospects of Non-drug Approaches to Alzheimer's Disease

Cited by 4 publications

References 104 publications

Effect of Terahertz Electromagnetic Irradiation at Nitric Oxide Frequencies on Concentration of Nitrites in Blood Serum of Albino Rats under Conditions of Immobilization Stress

Effect of Terahertz Electromagnetic Irradiation at Nitric Oxide Frequencies on Concentration of Nitrites in Blood Serum of Albino Rats under Conditions of Immobilization Stress

Plant Adaptogens: Natural Medicaments for 21stCentury?

Role of Nitric Oxide in Prevention of Cognitive Disorders in Neurodegenerative Brain Injuries in Rats

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Plant Adaptogens: Natural Medicaments for 21^stCentury?