Prospects for the treatment of diabetic retinopathy: Modulation of endothelial growth factor

Кузьмин, А. Г.; Геннадьевич, Кузьмин Анатолий; Smirnova, Olga Mikhailovna; Михайловна, Смирнова Ольга; Lipatov, Dmitriy Valentinovich; Валентинович, Липатов Дмитрий; Shestakova, Marina Vladimirovna; Владимировна, Шестакова Марина

doi:10.14341/2072-0351-5395

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…Recent studies indicate to increased intracellular concentrations in hypoxia-inducible transcription factor (HIF)-1 alpha, an essential regulator of the cellular response to reduced oxygen levels, in the retina of healthy individuals. Increased intracellular HIF-1 level enhances transcription of VEGF gene effecting the epithelium through intercelullar matrix, contributes to regeneration and stimulates proliferation and formation of new vessels [28]. Hyperplastic osteoid tissue affects VEGF synthesis with higher osteoblast concentration, and the combination of the factors results in several-fold increase of VEGF and VEGF-А level as compared to that observed in healthy individuals but without proportinal receptor increase due to pathology.…”

Section: Discussionmentioning

confidence: 99%

Specific dynamics in vascular endothelial growth factors (VEGF) in blood of patients with vitamin D-resistant rickets during correction of multiplanar deformities of lower limbs

Gvozdev¹,

Vykhovanets²,

Лунева³

et al. 2020

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Background Vitamin D-resistant rickets is a systemic disease with impaired bone remodeling that interferes with orthopaedic treatment of musculoskeletal pathologies. There is a paucity of literature focusing on the content and dynamics in vascular endothelial growth factors (VEGF) that promote the transformation of cartilage to bone. Objective Explore blood serum concentration of VEGF and VEGF-А and their receptors VEGF-R2, VEGF-R3 at stages of combined osteosynthesis in patients with vitamin D-resistant rickets during correction of multiplanar deformities of lower limbs. Material and methods The study included 24 patients with multiplanar deformities of lower limbs secondary to vitamin D-resistant rickets. Patients were treated with combined Ilizarov external fixation and intramedullary nailing using hydroxyapatite-coated wires. Serum concentration of VEGF and VEGF-А and their receptors VEGF-R2, VEGF-R3 were measured during treatment. Values obtained in the patients were compared to reference levels measured in 180 somatically healthy individuals. The quantified results were presented in a percentage of the reference values. Results Preoperative serum VEGF and VEGF-R2 concentration was significantly higher in the patients than that in normal subjects: VEGF, by 1990 % (р = 0.0033); VEGF-A, by 450 % (р = 0.00042); VEGF-R2, by 392 % (р = 0.0052) while preoperative serum VEGF-R3 concentration was lower by 68 % (p < 0.05) in the patients than that in subjectively healthy individuals. Surgical treatment resulted in greater increase in VEGF, VEGF-A levels with maximal concentration observed at the distraction phase. The opposite dynamics was observed with VEGF-R2 receptor. Specific dynamics was noted with VEGF-R3 receptor during surgical correction. Nearly preoperative serum concentration of VEGF-R3 was seen at the first stage showing the lowest level (21% of the normal) during bone distraction with external fixator and regenerate formation. It was reduced by 25 % of the preoperative level at the end of treatment. Conclusion Patients with vitamin D-resistant rickets demonstrated strong imbalance in serum concentrations of VEGFs and their receptors. Phase opposition dynamics in serum concentrations of VEGFs and their receptors was detected during surgical correction of multiplanar deformities of lower limbs.

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Section: Discussionmentioning

confidence: 99%

Specific dynamics in vascular endothelial growth factors (VEGF) in blood of patients with vitamin D-resistant rickets during correction of multiplanar deformities of lower limbs

Gvozdev¹,

Vykhovanets²,

Лунева³

et al. 2020

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“…В настоящее время гиперпродукции VEGF отводят ведущую роль в повышении проницаемости ретинальных сосудов, развитии отека макулы и неоваскуляризации сет-чатки при СД [19][20][21]. Мощным триггером повышения синтеза VEGF и его рецепторов при ДР является гипоксия или ишемия сетчатки.…”

Section: обоснование применения анти-Vegf терапии при дмоunclassified

Anti-VEGF agents in the treatment of diabetic macular edema

Иосифович²,

Климонтов

et al. 2013

Diabetes mellitus

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Diabetic macular edema (DME) is a common complication associated with the loss of visual acuity in diabetic patients. Intravitreal injections of vascular endothelium growth factor (VEGF) inhibitors (anti-VEGF therapy) have been proposed recently as a new treatment option for patients with DME. In this review we summarized results of randomized clinical trials of VEGF inhibitors in DME patients. The results indicate that all studied inhibitors (ranibizumab, bevacizumab, pegaptanib and aflibersept) reduce the retinal thickness and improve of visual acuity in DME when are used as a monotherapy or in combination with the laser treatment. Optimal course duration and effectiveness predictors of anti-VEGF therapy in DME should be elucidate in the future studies.

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Changes in intraocular pressure after intravitreal injections

Kurguzova

2018

Vestn. oftal'mol.

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Prospects for the treatment of diabetic retinopathy: Modulation of endothelial growth factor

Cited by 3 publications

References 28 publications

Specific dynamics in vascular endothelial growth factors (VEGF) in blood of patients with vitamin D-resistant rickets during correction of multiplanar deformities of lower limbs

Specific dynamics in vascular endothelial growth factors (VEGF) in blood of patients with vitamin D-resistant rickets during correction of multiplanar deformities of lower limbs

Anti-VEGF agents in the treatment of diabetic macular edema

Changes in intraocular pressure after intravitreal injections

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