Prospects for cryo-immunotherapy in cases of metastasizing carcinoma of the prostate

Rj, Alblin; Wa, Soanes; Mj, Gonder

doi:10.1016/0011-2240(71)90050-2

Cited by 111 publications

(40 citation statements)

References 8 publications

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“…)-specific antigens or TAA may explain in part, the difficulty of other investigators in demonstrating antibodies in patients with CaP following cryotherapy. Both the physiologic function of antiprostatic epithelial antibodies, i.e., are they of a cytotoxic nature as previously hypothesized [5,6] or do they possibly interfere with comple ment-mediated cytotoxic and function in the capacity of 'blocking anti bodies' [15], their relevance to recently observed 'unbound' antibodies in patients with benign and malignant diseases of the prostate reactive with other sources of epithelium [16] and the number of patients evaluated shall require much further study.…”

Section: Discussionmentioning

confidence: 99%

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Immunohistologic Studies of Carcinoma of the Prostate

Ablin¹,

Gonder²,

Soanes³

1974

Oncology

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Interepithelial antibodies reactive with autologous (human) and heterologous (monkey) prostatic tissue have been demonstrated by the method of indirect immunofluorescence in an eluate of carcinomatous prostatic tissue obtained at autopsy from a patient with metastatic adenocarcinoma of the prostate who exhibited remission of both his local prostatic malignancy and osteolytic lesions of the cervical spine following cryotherapy of his primary prostatic tumour. Elution of antibodies from malignant prostatic tissue provides evidence of a preliminary nature that prostatic tissue (tumor?)-specific or tumor-associated antigens are liberated into the circulation following cryotherapy of the human prostate and offers further support to previous studies suggestive of the role of immunologic processes in prostatic cancer.

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Section: Discussionmentioning

confidence: 99%

“…J.) with stage III metastatic CaP [4], who following multiple in situ freezing of his primary prostatic tumor exhibited as previously de scribed [5,6] remission of both his local prostatic malignancy and osteolytic lesions of the cervical spine.…”

mentioning

confidence: 99%

Immunohistologic Studies of Carcinoma of the Prostate

Ablin¹,

Gonder²,

Soanes³

1974

Oncology

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“…102 Early clinical studies using cryoablation demonstrated regression of untreated metastatic lesions and indications of antitumor immunity. [103][104][105][106] More recent clinical studies have demonstrated increases in serum cytokines and generation of tumor-specific T-cells following cryoabaltion. 107,108 The simplicity of cryoablation, coupled with minimal negative effects on the immune system, make this procedure an attractive candidate for combination with immunotherapy.…”

Section: Regulatory T-cellsmentioning

confidence: 99%

Enhancing immune responses to tumor-associated antigens

Higgins¹,

Bernstein²,

Hodge³

2009

Cancer Biology & Therapy

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The goal of vaccine-based cancer immunotherapy is to induce a tumor-specific immune response that ultimately reduces tumor burden. However, the immune system is often tolerant to antigens presented by the tumor, as the cancer originates from within a patient and is therefore recognized as self. This article reviews selected clinical strategies for overcoming this immune tolerance, and approaches to enhance generation of immunity to tumor-associated antigens by activating innate immunity, potentiating adaptive immunity, reducing immunosuppression, and enhancing tumor immunogenicity. Success in the field of cancer vaccines has yet to be fully realized, but intelligent choice of immunomodulators, tumor antigens and patient populations will likely lead to clinically relevant uses for cancer vaccines.

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“…In addition to the successful cryoablation of the primary tumour (8,20,22,25,38,40), reports of metastatic tumour destruction (8,25,38,40) have suggested that an augmentation or inducement of host resistance, possibly immunologic in nature, may occur as a result of in situ cryogenic destruction. Recent reviews (4,17) have traced the early experimental and clinical developments leading to.…”

Section: Rationale and Backgroundmentioning

confidence: 99%

Cryoimmunotherapy: Continuing Studies toward Determining a Rational Approach for Assessing the Candidacy of the Prostatic Cancer Patient for Cryoimmunotherapy and Postoperative Responsiveness

Ablin

Fontana²

1979

Eur Surg Res

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Cryosurgery (in situ freezing) is a recognized method for the controlled cryogenic destruction of benign and malignant tissues and has been efficaciously employed for the treatment of prostatic cancer. In situ freezing constitutes an antigenic stimulus capable of generating a specific immunologic response against autologous antigens of the tissue frozen, ergo, cryostimulation. The phenomenon of cryostimulation has, in light of

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Prospects for cryo-immunotherapy in cases of metastasizing carcinoma of the prostate

Cited by 111 publications

References 8 publications

Immunohistologic Studies of Carcinoma of the Prostate

Immunohistologic Studies of Carcinoma of the Prostate

Enhancing immune responses to tumor-associated antigens

Cryoimmunotherapy: Continuing Studies toward Determining a Rational Approach for Assessing the Candidacy of the Prostatic Cancer Patient for Cryoimmunotherapy and Postoperative Responsiveness

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